Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Abcg2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ABCG2
- Mouse genes Abcg2
- Rat genes Abcg2
- Zfish genes abcg2a,abcg2d
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Abcg2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008559	ABC-type xenobiotic transporter activity	ABCG2	IDA		Human	PMID:9861027
Molecular Function	GO:0042887	amide transmembrane transporter activity	Abcg2	IDA		Rat	PMID:15255930\|RGD:1304349
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	ABCG2	IMP		Human	PMID:28554189
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	ABCG2	IMP		Human	PMID:30405239
Molecular Function	GO:0015225	biotin transmembrane transporter activity	Abcg2	IMP		Mouse	MGI:MGI:3699049\|PMID:17145775
Molecular Function	GO:0008092	cytoskeletal protein binding	Abcg2	IPI	RGD:1305848	Rat	PMID:23403943\|RGD:11530034
Molecular Function	GO:0008092	cytoskeletal protein binding	Abcg2	IPI	RGD:71024	Rat	PMID:23403943\|RGD:11530034
Molecular Function	GO:0015562	efflux transmembrane transporter activity	ABCG2	IMP		Human	PMID:17145775
Molecular Function	GO:0015562	efflux transmembrane transporter activity	ABCG2	IMP		Human	PMID:19506252
Molecular Function	GO:0015562	efflux transmembrane transporter activity	Abcg2	IMP		Mouse	MGI:MGI:3699049\|PMID:17145775
Molecular Function	GO:0015562	efflux transmembrane transporter activity	Abcg2	IDA		Rat	PMID:15773906\|RGD:14929200
Molecular Function	GO:0042802	identical protein binding	ABCG2	IPI	UniProtKB:Q9UNQ0	Human	PMID:16870176
Molecular Function	GO:0042802	identical protein binding	ABCG2	IPI	UniProtKB:Q9UNQ0	Human	PMID:17098188
Molecular Function	GO:0042802	identical protein binding	ABCG2	IPI	UniProtKB:Q9UNQ0	Human	PMID:19506252
Molecular Function	GO:0042802	identical protein binding	ABCG2	IPI	UniProtKB:Q9UNQ0	Human	PMID:20399185
Molecular Function	GO:0008514	organic anion transmembrane transporter activity	Abcg2	IDA		Rat	PMID:15773906\|RGD:14929200
Molecular Function	GO:0005515	protein binding	ABCG2	IPI	UniProtKB:P11309-2	Human	PMID:18056989
Molecular Function	GO:0005515	protein binding	ABCG2	IPI	UniProtKB:P0CG48	Human	PMID:19909340
Molecular Function	GO:0042803	protein homodimerization activity	ABCG2	IDA		Human	PMID:16870176
Molecular Function	GO:0032217	riboflavin transmembrane transporter activity	ABCG2	IDA		Human	PMID:17145775
Molecular Function	GO:0032217	riboflavin transmembrane transporter activity	Abcg2	IMP		Mouse	MGI:MGI:3699049\|PMID:17145775
Molecular Function	GO:0015143	urate transmembrane transporter activity	ABCG2	IMP		Human	PMID:19506252
Molecular Function	GO:0042910	xenobiotic transmembrane transporter activity	Abcg2	IDA		Rat	PMID:15773906\|RGD:14929200
Cellular Component	GO:0016324	apical plasma membrane	Abcg2	IDA		Mouse	MGI:MGI:2446004\|PMID:12429862
Cellular Component	GO:0016324	apical plasma membrane	Abcg2	IDA		Rat	PMID:18451542\|RGD:2315580
Cellular Component	GO:0016324	apical plasma membrane	Abcg2	IDA		Rat	PMID:21737571\|RGD:25671393
Cellular Component	GO:0043190	ATP-binding cassette (ABC) transporter complex	abcg2a	IDA		Zfish	PMID:17932252
Cellular Component	GO:0031526	brush border membrane	ABCG2	IDA		Human	PMID:19506252
Cellular Component	GO:0098591	external side of apical plasma membrane	Abcg2	IDA		Rat	PMID:18619525\|RGD:2301072
Cellular Component	GO:0016020	membrane	Abcg2	IDA		Rat	PMID:15255930\|RGD:1304349
Cellular Component	GO:0045121	membrane raft	ABCG2	IDA		Human	PMID:28623970
Cellular Component	GO:0005654	nucleoplasm	ABCG2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Abcg2	IDA		Rat	PMID:15255930\|RGD:1304349
Cellular Component	GO:0005886	plasma membrane	ABCG2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ABCG2	IDA		Human	PMID:18619525
Cellular Component	GO:0005886	plasma membrane	ABCG2	IDA		Human	PMID:23137377
Cellular Component	GO:0005886	plasma membrane	Abcg2	IDA		Rat	PMID:28679589\|RGD:13439745
Biological Process	GO:0007568	aging	Abcg2	IEP		Rat	PMID:26990146\|RGD:13463595
Biological Process	GO:0015878	biotin transport	Abcg2	IMP		Mouse	MGI:MGI:3699049\|PMID:17145775
Biological Process	GO:1990748	cellular detoxification	ABCG2	IDA		Human	PMID:9861027
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Abcg2	IEP		Rat	PMID:18524938\|RGD:2315579
Biological Process	GO:0071392	cellular response to estradiol stimulus	Abcg2	IEP		Rat	PMID:23592396\|RGD:11099979
Biological Process	GO:0060136	embryonic process involved in female pregnancy	Abcg2	IDA		Rat	PMID:18450391\|RGD:2315582
Biological Process	GO:0140115	export across plasma membrane	Abcg2	IDA		Rat	PMID:15773906\|RGD:14929200
Biological Process	GO:0019389	glucuronoside metabolic process	Abcg2	IMP		Rat	PMID:15598971\|RGD:11099974
Biological Process	GO:1904479	negative regulation of intestinal absorption	Abcg2	IMP		Rat	PMID:23333829\|RGD:11099975
Biological Process	GO:0015711	organic anion transport	Abcg2	IDA		Rat	PMID:15773906\|RGD:14929200
Biological Process	GO:0065003	protein-containing complex assembly	Abcg2	IDA		Rat	PMID:15255930\|RGD:1304349
Biological Process	GO:0097744	renal urate salt excretion	ABCG2	IMP		Human	PMID:19506252
Biological Process	GO:0097744	renal urate salt excretion	Abcg2	IEP		Rat	PMID:28679589\|RGD:13439745
Biological Process	GO:1904612	response to 2,3,7,8-tetrachlorodibenzodioxine	Abcg2	IEP		Rat	PMID:22472606\|RGD:11099986
Biological Process	GO:0051593	response to folic acid	Abcg2	IEP		Rat	PMID:19552531\|RGD:2316102
Biological Process	GO:0032868	response to insulin	Abcg2	IEP		Rat	PMID:28679589\|RGD:13439745
Biological Process	GO:0010039	response to iron ion	Abcg2	IEP		Rat	PMID:15637178\|RGD:2315589
Biological Process	GO:0032496	response to lipopolysaccharide	Abcg2	IEP		Rat	PMID:18505788\|RGD:2301058
Biological Process	GO:0043278	response to morphine	Abcg2	IEP		Rat	PMID:22845665\|RGD:11099987
Biological Process	GO:0032218	riboflavin transport	ABCG2	IDA		Human	PMID:17145775
Biological Process	GO:0032218	riboflavin transport	Abcg2	IMP		Mouse	MGI:MGI:3699049\|PMID:17145775
Biological Process	GO:0070633	transepithelial transport	ABCG2	IDA		Human	PMID:12958161
Biological Process	GO:0055085	transmembrane transport	ABCG2	IMP		Human	PMID:28554189
Biological Process	GO:0055085	transmembrane transport	ABCG2	IMP		Human	PMID:30405239
Biological Process	GO:0055085	transmembrane transport	Abcg2	IMP		Rat	PMID:16809480\|RGD:11099978
Biological Process	GO:0055085	transmembrane transport	Abcg2	IMP		Rat	PMID:19105722\|RGD:2315575
Biological Process	GO:0046415	urate metabolic process	ABCG2	IMP		Human	PMID:18834626
Biological Process	GO:0046415	urate metabolic process	ABCG2	IMP		Human	PMID:19503597
Biological Process	GO:0046415	urate metabolic process	ABCG2	IMP		Human	PMID:20053405
Biological Process	GO:0015747	urate transport	Abcg2	IMP		Rat	PMID:22348008\|RGD:11099980
Biological Process	GO:1990961	xenobiotic detoxification by transmembrane export across the plasma membrane	Abcg2	IDA		Rat	PMID:15255930\|RGD:1304349
Biological Process	GO:1990962	xenobiotic transport across blood-brain barrier	ABCG2	IDA		Human	PMID:12958161

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.