Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ABCG4
  • Mouse genes Abcg4
  • Rat genes Abcg4
  • Zfish genes abcg4a,abcg4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Abcg4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0034041	ABC-type sterol transporter activity	Abcg4	IMP		Mouse	MGI:MGI:3047008|PMID:15210959
Molecular Function	GO:0016887	ATP hydrolysis activity	ABCG4	IDA		Human	PMID:15240127
Molecular Function	GO:0042802	identical protein binding	ABCG4	IDA		Human	PMID:27228027
Molecular Function	GO:0005515	protein binding	ABCG4	IPI	UniProtKB:P45844-4	Human	PMID:16870176
Molecular Function	GO:0005515	protein binding	ABCG4	IPI	UniProtKB:P45844	Human	PMID:27228027
Molecular Function	GO:0005515	protein binding	ABCG4	IPI	UniProtKB:O95807	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ABCG4	IPI	UniProtKB:Q8TDT2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ABCG4	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ABCG4	IPI	UniProtKB:Q9H8W4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ABCG4	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0046982	protein heterodimerization activity	ABCG4	IPI	UniProtKB:P45844	Human	PMID:16870176
Molecular Function	GO:0046982	protein heterodimerization activity	ABCG4	IDA		Human	PMID:27228027
Molecular Function	GO:0042803	protein homodimerization activity	ABCG4	IDA		Human	PMID:16870176
Cellular Component	GO:0031410	cytoplasmic vesicle	Abcg4	IDA		Mouse	MGI:MGI:3768186|PMID:17916878
Cellular Component	GO:0005768	endosome	Abcg4	IDA		Mouse	MGI:MGI:3768186|PMID:17916878
Cellular Component	GO:0010008	endosome membrane	Abcg4	IDA		Mouse	MGI:MGI:3768186|PMID:17916878
Cellular Component	GO:0005886	plasma membrane	ABCG4	IDA		Human	PMID:27228027
Biological Process	GO:0071403	cellular response to high density lipoprotein particle stimulus	Abcg4	IDA		Mouse	MGI:MGI:3047008|PMID:15210959
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Abcg4	IEP		Mouse	PMID:20439489
Biological Process	GO:0033344	cholesterol efflux	ABCG4	IMP		Human	PMID:33141061
Biological Process	GO:0033344	cholesterol efflux	Abcg4	IMP		Mouse	MGI:MGI:3818784|PMID:18039927
Biological Process	GO:0033344	cholesterol efflux	Abcg4	IMP		Mouse	MGI:MGI:3047008|PMID:15210959
Biological Process	GO:0042632	cholesterol homeostasis	Abcg4	IMP		Mouse	MGI:MGI:3768186|PMID:17916878
Biological Process	GO:0045542	positive regulation of cholesterol biosynthetic process	Abcg4	IMP		Mouse	MGI:MGI:3768186|PMID:17916878
Biological Process	GO:0010875	positive regulation of cholesterol efflux	Abcg4	IDA		Mouse	MGI:MGI:3047008|PMID:15210959
Biological Process	GO:0006355	regulation of DNA-templated transcription	Abcg4	IMP		Mouse	MGI:MGI:3768186|PMID:17916878
Biological Process	GO:0015918	sterol transport	Abcg4	IMP		Mouse	MGI:MGI:3818784|PMID:18039927

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern