Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ABCG8
  • Mouse genes Abcg8
  • Rat genes Abcg8
  • Zfish genes abcg8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Abcg8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	ABCG8	IDA		Human	PMID:16893193
Molecular Function	GO:0016887	ATP hydrolysis activity	ABCG8	IDA		Human	PMID:16893193
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	ABCG8	IDA		Human	PMID:27144356
Molecular Function	GO:0120020	cholesterol transfer activity	ABCG8	IGI	UniProtKB:Q9DBM0	Human	PMID:14504269
Molecular Function	GO:0120020	cholesterol transfer activity	Abcg8	IMP		Mouse	MGI:MGI:2681374|PMID:14504269
Molecular Function	GO:0005515	protein binding	ABCG8	IPI	UniProtKB:Q9H222	Human	PMID:16870176
Molecular Function	GO:0005515	protein binding	ABCG8	IPI	UniProtKB:Q14696	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Abcg8	IPI	UniProtKB:Q99PE8	Mouse	MGI:MGI:6095614|PMID:12208867
Molecular Function	GO:0046982	protein heterodimerization activity	ABCG8	IPI	UniProtKB:Q9H222	Human	PMID:16870176
Molecular Function	GO:0046982	protein heterodimerization activity	Abcg8	IDA		Mouse	MGI:MGI:6095614|PMID:12208867
Cellular Component	GO:0016324	apical plasma membrane	ABCG8	IMP		Human	PMID:14504269
Cellular Component	GO:0016324	apical plasma membrane	Abcg8	IDA		Mouse	MGI:MGI:6095614|PMID:12208867
Cellular Component	GO:0016324	apical plasma membrane	Abcg8	IMP		Mouse	MGI:MGI:2681374|PMID:14504269
Cellular Component	GO:0016324	apical plasma membrane	Abcg8	IDA		Mouse	MGI:MGI:3695229|PMID:16867993
Cellular Component	GO:0043190	ATP-binding cassette (ABC) transporter complex	ABCG8	IDA		Human	PMID:16893193
Cellular Component	GO:0043190	ATP-binding cassette (ABC) transporter complex	ABCG8	IDA		Human	PMID:27144356
Cellular Component	GO:0005886	plasma membrane	Abcg8	IDA		Mouse	MGI:MGI:6095614|PMID:12208867
Cellular Component	GO:0043235	receptor complex	ABCG8	IDA		Human	PMID:14504269
Cellular Component	GO:0043235	receptor complex	Abcg8	IDA		Mouse	MGI:MGI:2681374|PMID:14504269
Biological Process	GO:0038183	bile acid signaling pathway	Abcg8	IEP		Rat	PMID:25263431|RGD:15045610
Biological Process	GO:0033344	cholesterol efflux	ABCG8	IGI	UniProtKB:Q9DBM0	Human	PMID:14504269
Biological Process	GO:0033344	cholesterol efflux	ABCG8	IMP		Human	PMID:27144356
Biological Process	GO:0033344	cholesterol efflux	ABCG8	IMP	UniProtKB:Q9H222	Human	PMID:27144356
Biological Process	GO:0033344	cholesterol efflux	Abcg8	IMP		Mouse	MGI:MGI:2681374|PMID:14504269
Biological Process	GO:0042632	cholesterol homeostasis	ABCG8	IMP		Human	PMID:11099417
Biological Process	GO:0042632	cholesterol homeostasis	ABCG8	IMP		Human	PMID:27144356
Biological Process	GO:0042632	cholesterol homeostasis	Abcg8	IMP	MGI:MGI:3514037	Mouse	PMID:15040800
Biological Process	GO:0042632	cholesterol homeostasis	Abcg8	IEP		Rat	PMID:23117815|RGD:15045604
Biological Process	GO:0045796	negative regulation of intestinal cholesterol absorption	ABCG8	IMP		Human	PMID:11099417
Biological Process	GO:0010949	negative regulation of intestinal phytosterol absorption	ABCG8	IMP		Human	PMID:11099417
Biological Process	GO:0015914	phospholipid transport	Abcg8	IMP	MGI:MGI:3514037	Mouse	PMID:15040800
Biological Process	GO:0014850	response to muscle activity	Abcg8	IEP		Rat	PMID:23117815|RGD:15045604
Biological Process	GO:0007584	response to nutrient	Abcg8	IEP		Rat	PMID:15710224|RGD:1598545
Biological Process	GO:0031667	response to nutrient levels	Abcg8	IEP		Rat	PMID:23117815|RGD:15045604
Biological Process	GO:0031667	response to nutrient levels	Abcg8	IEP		Rat	PMID:25263431|RGD:15045610
Biological Process	GO:0009410	response to xenobiotic stimulus	Abcg8	IEP		Rat	PMID:17109865|RGD:1598661
Biological Process	GO:0055092	sterol homeostasis	Abcg8	IMP	MGI:MGI:3514037	Mouse	PMID:15040800
Biological Process	GO:0015918	sterol transport	Abcg8	IDA		Mouse	MGI:MGI:3695229|PMID:16867993
Biological Process	GO:0015918	sterol transport	Abcg8	IMP	MGI:MGI:3514037	Mouse	PMID:15040800
Biological Process	GO:0070328	triglyceride homeostasis	Abcg8	IEP		Rat	PMID:23117815|RGD:15045604

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern