Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACACA
  • Mouse genes Acaca
  • Rat genes Acaca
  • Zfish genes acaca
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Acaca

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003989	acetyl-CoA carboxylase activity	ACACA	IDA		Human	PMID:20457939
Molecular Function	GO:0003989	acetyl-CoA carboxylase activity	ACACA	IDA		Human	PMID:26976583
Molecular Function	GO:0003989	acetyl-CoA carboxylase activity	ACACA	IDA		Human	PMID:29899443
Molecular Function	GO:0003989	acetyl-CoA carboxylase activity	Acaca	IDA		Mouse	MGI:MGI:4840155|PMID:20952656
Molecular Function	GO:0003989	acetyl-CoA carboxylase activity	Acaca	IGI	MGI:MGI:2140940	Mouse	PMID:17210641
Molecular Function	GO:0003989	acetyl-CoA carboxylase activity	Acaca	IMP	MGI:MGI:3641125	Mouse	PMID:16717184
Molecular Function	GO:0003989	acetyl-CoA carboxylase activity	Acaca	IMP		Mouse	PMID:8954960
Molecular Function	GO:0003989	acetyl-CoA carboxylase activity	Acaca	IDA		Rat	PMID:11735100|RGD:2317316
Molecular Function	GO:0003989	acetyl-CoA carboxylase activity	Acaca	IDA		Rat	PMID:21569266|RGD:10047183
Molecular Function	GO:0009374	biotin binding	Acaca	IDA		Rat	PMID:12949377|RGD:1601566
Molecular Function	GO:0042802	identical protein binding	ACACA	IPI	UniProtKB:Q13085	Human	PMID:20457939
Molecular Function	GO:0019900	kinase binding	Acaca	IPI	RGD:70497	Rat	PMID:16026327|RGD:5132881
Molecular Function	GO:0005515	protein binding	ACACA	IPI	UniProtKB:P38398	Human	PMID:16326698
Molecular Function	GO:0005515	protein binding	ACACA	IPI	UniProtKB:Q8K4K2	Human	PMID:16794074
Molecular Function	GO:0005515	protein binding	ACACA	IPI	UniProtKB:O60218	Human	PMID:18056116
Molecular Function	GO:0005515	protein binding	ACACA	IPI	UniProtKB:Q96EB6	Human	PMID:19343720
Molecular Function	GO:0005515	protein binding	ACACA	IPI	UniProtKB:Q9CQ20	Human	PMID:20457939
Molecular Function	GO:0005515	protein binding	ACACA	IPI	UniProtKB:Q9CQ20	Human	PMID:20952656
Molecular Function	GO:0005515	protein binding	ACACA	IPI	UniProtKB:P38398	Human	PMID:29899443
Molecular Function	GO:0005515	protein binding	Acaca	IPI	UniProtKB:Q9CQ20	Mouse	MGI:MGI:4454592|PMID:20457939
Cellular Component	GO:0015629	actin cytoskeleton	ACACA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	ACACA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Acaca	IDA		Mouse	MGI:MGI:4840155|PMID:20952656
Cellular Component	GO:0005829	cytosol	Acaca	IGI	MGI:MGI:2140940	Mouse	PMID:17210641
Cellular Component	GO:0005829	cytosol	Acaca	IDA		Mouse	PMID:16717184
Cellular Component	GO:0001650	fibrillar center	ACACA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Acaca	HDA		Mouse	PMID:18614015
Biological Process	GO:0006084	acetyl-CoA metabolic process	Acaca	IDA		Mouse	MGI:MGI:4840155|PMID:20952656
Biological Process	GO:0071380	cellular response to prostaglandin E stimulus	Acaca	IDA		Mouse	PMID:23479225
Biological Process	GO:0006633	fatty acid biosynthetic process	Acaca	IDA		Mouse	MGI:MGI:4840155|PMID:20952656
Biological Process	GO:0006633	fatty acid biosynthetic process	Acaca	IDA		Rat	PMID:11735100|RGD:2317316
Biological Process	GO:0008610	lipid biosynthetic process	Acaca	IGI	MGI:MGI:2140940	Mouse	PMID:17210641
Biological Process	GO:0008610	lipid biosynthetic process	Acaca	IMP	MGI:MGI:3641125	Mouse	PMID:16717184
Biological Process	GO:0055088	lipid homeostasis	Acaca	IMP	MGI:MGI:3700954	Mouse	PMID:17210641
Biological Process	GO:0006629	lipid metabolic process	Acaca	IMP	MGI:MGI:3700954	Mouse	PMID:17210641
Biological Process	GO:0051289	protein homotetramerization	Acaca	IDA		Mouse	MGI:MGI:4840155|PMID:20952656
Biological Process	GO:0019538	protein metabolic process	Acaca	IMP	MGI:MGI:3700955	Mouse	PMID:17210641
Biological Process	GO:0019538	protein metabolic process	Acaca	IMP	MGI:MGI:3700954	Mouse	PMID:17210641
Biological Process	GO:0061959	response to (R)-carnitine	acaca	IEP		Zfish	PMID:28102299
Biological Process	GO:0031667	response to nutrient levels	Acaca	IEP		Rat	PMID:25943649|RGD:152995488
Biological Process	GO:0014070	response to organic cyclic compound	Acaca	IMP		Rat	PMID:12842871|RGD:1625730
Biological Process	GO:0009410	response to xenobiotic stimulus	Acaca	IEP		Rat	PMID:16979414|RGD:1625728
Biological Process	GO:0001894	tissue homeostasis	Acaca	IMP	MGI:MGI:3700954	Mouse	PMID:17210641
Biological Process	GO:0001894	tissue homeostasis	Acaca	IMP	MGI:MGI:3700955	Mouse	PMID:17210641

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern