Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACACB
  • Mouse genes Acacb
  • Rat genes Acacb
  • Zfish genes acacb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Acacb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003989	acetyl-CoA carboxylase activity	ACACB	IDA		Human	PMID:19236960
Molecular Function	GO:0003989	acetyl-CoA carboxylase activity	ACACB	IDA		Human	PMID:20457939
Molecular Function	GO:0003989	acetyl-CoA carboxylase activity	ACACB	IDA		Human	PMID:20952656
Molecular Function	GO:0003989	acetyl-CoA carboxylase activity	ACACB	IDA		Human	PMID:26976583
Molecular Function	GO:0003989	acetyl-CoA carboxylase activity	Acacb	IMP		Mouse	PMID:17210641
Molecular Function	GO:0003989	acetyl-CoA carboxylase activity	Acacb	IDA		Mouse	PMID:17210641
Molecular Function	GO:0009374	biotin binding	Acacb	IDA		Rat	PMID:12949377|RGD:1601566
Molecular Function	GO:0042802	identical protein binding	ACACB	IPI	UniProtKB:O00763	Human	PMID:20457939
Molecular Function	GO:0005515	protein binding	ACACB	IPI	UniProtKB:Q8K4K2	Human	PMID:16794074
Molecular Function	GO:0005515	protein binding	ACACB	IPI	UniProtKB:P50747	Human	PMID:20085763
Molecular Function	GO:0005515	protein binding	ACACB	IPI	UniProtKB:Q9CQ20	Human	PMID:20457939
Molecular Function	GO:0005515	protein binding	ACACB	IPI	UniProtKB:Q9CQ20	Human	PMID:20952656
Cellular Component	GO:0005739	mitochondrion	ACACB	IDA		Human	PMID:10677481
Cellular Component	GO:0005739	mitochondrion	Acacb	IDA		Mouse	MGI:MGI:5582184|PMID:10677481
Cellular Component	GO:0005739	mitochondrion	Acacb	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Acacb	IDA		Rat	PMID:10677481|RGD:1625731
Cellular Component	GO:0005634	nucleus	ACACB	IDA		Human	PMID:10677481
Biological Process	GO:0006084	acetyl-CoA metabolic process	ACACB	IDA		Human	PMID:20952656
Biological Process	GO:0097009	energy homeostasis	Acacb	IMP		Mouse	MGI:MGI:3629477|PMID:12920182
Biological Process	GO:0006633	fatty acid biosynthetic process	Acacb	IMP		Mouse	PMID:17210641
Biological Process	GO:2001295	malonyl-CoA biosynthetic process	Acacb	IMP		Mouse	MGI:MGI:3804564|PMID:18487439
Biological Process	GO:0043086	negative regulation of catalytic activity	Acacb	IDA		Mouse	MGI:MGI:3629477|PMID:12920182
Biological Process	GO:0031999	negative regulation of fatty acid beta-oxidation	Acacb	IMP		Mouse	MGI:MGI:3530688|PMID:15677334
Biological Process	GO:0031999	negative regulation of fatty acid beta-oxidation	Acacb	IMP		Mouse	MGI:MGI:3629477|PMID:12920182
Biological Process	GO:0046322	negative regulation of fatty acid oxidation	Acacb	IMP		Mouse	MGI:MGI:3804564|PMID:18487439
Biological Process	GO:0046322	negative regulation of fatty acid oxidation	Acacb	IMP		Mouse	MGI:MGI:1932690|PMID:11283375
Biological Process	GO:0010629	negative regulation of gene expression	Acacb	IMP		Mouse	MGI:MGI:3629477|PMID:12920182
Biological Process	GO:0050995	negative regulation of lipid catabolic process	Acacb	IMP		Mouse	MGI:MGI:3530688|PMID:15677334
Biological Process	GO:0060421	positive regulation of heart growth	Acacb	IMP		Mouse	MGI:MGI:3804564|PMID:18487439
Biological Process	GO:0010884	positive regulation of lipid storage	Acacb	IMP		Mouse	MGI:MGI:1932690|PMID:11283375
Biological Process	GO:0051289	protein homotetramerization	ACACB	IDA		Human	PMID:20952656
Biological Process	GO:0010906	regulation of glucose metabolic process	Acacb	IMP		Mouse	MGI:MGI:3530688|PMID:15677334
Biological Process	GO:0031667	response to nutrient levels	Acacb	IMP		Mouse	MGI:MGI:3629477|PMID:12920182
Biological Process	GO:0031667	response to nutrient levels	Acacb	IMP		Mouse	MGI:MGI:3530688|PMID:15677334
Biological Process	GO:0031667	response to nutrient levels	Acacb	IEP		Rat	PMID:25943649|RGD:152995488
Biological Process	GO:0014070	response to organic cyclic compound	Acacb	IMP		Rat	PMID:12842871|RGD:1625730
Biological Process	GO:0009410	response to xenobiotic stimulus	Acacb	IEP		Rat	PMID:16979414|RGD:1625728

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern