Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACAN
  • Mouse genes Acan
  • Rat genes Acan
  • Zfish genes acana,acanb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Acan

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	Acan	IDA		Rat	PMID:15296743|RGD:2315856
Molecular Function	GO:0005515	protein binding	ACAN	IPI	UniProtKB:P49747	Human	PMID:17588949
Molecular Function	GO:0005515	protein binding	ACAN	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Acan	IPI	UniProtKB:B5DFF0	Mouse	MGI:MGI:5294318|PMID:9368062
Molecular Function	GO:0005515	protein binding	Acan	IPI	PR:Q08879	Mouse	PMID:16061471
Cellular Component	GO:0005604	basement membrane	Acan	IDA		Mouse	PMID:16061471
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ACAN	HDA		Human	PMID:20551380
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ACAN	HDA		Human	PMID:27068509
Cellular Component	GO:0031012	extracellular matrix	Acan	IDA		Mouse	PMID:16079159
Cellular Component	GO:0031012	extracellular matrix	Acan	IDA		Mouse	PMID:14620382
Cellular Component	GO:0005615	extracellular space	Acan	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Acan	IDA		Rat	PMID:20603097|RGD:11570541
Cellular Component	GO:0098982	GABA-ergic synapse	Acan	IDA		Mouse	PMID:27615741
Cellular Component	GO:0098978	glutamatergic synapse	Acan	IDA		Mouse	PMID:27615741
Cellular Component	GO:0043005	neuron projection	Acan	IDA		Rat	PMID:22306080|RGD:11570549
Cellular Component	GO:0043025	neuronal cell body	Acan	IDA		Rat	PMID:22306080|RGD:11570549
Cellular Component	GO:0072534	perineuronal net	Acan	IDA		Rat	PMID:18364019|RGD:2315810
Cellular Component	GO:0098966	perisynaptic extracellular matrix	Acan	IDA		Mouse	PMID:27615741
Biological Process	GO:0001502	cartilage condensation	Acan	IMP	MGI:MGI:1856465	Mouse	PMID:3070812
Biological Process	GO:0071363	cellular response to growth factor stimulus	Acan	IEP		Rat	PMID:19968598|RGD:2315749
Biological Process	GO:0007417	central nervous system development	Acan	IEP		Rat	PMID:12701107|RGD:1358274
Biological Process	GO:0060591	chondroblast differentiation	Acan	IEP		Rat	PMID:20001227|RGD:2315747
Biological Process	GO:0002063	chondrocyte development	Acan	IMP	MGI:MGI:1856465	Mouse	PMID:9664687
Biological Process	GO:0030199	collagen fibril organization	Acan	IMP	MGI:MGI:1856465	Mouse	PMID:3070812
Biological Process	GO:0031101	fin regeneration	acanb	IMP	ZFIN:ZDB-MRPHLNO-160413-13	Zfish	PMID:26828861
Biological Process	GO:0031101	fin regeneration	acanb	IMP	ZFIN:ZDB-MRPHLNO-160413-14	Zfish	PMID:26828861
Biological Process	GO:0007507	heart development	Acan	IMP		Mouse	PMID:25807483
Biological Process	GO:0010259	multicellular organism aging	Acan	IEP		Rat	PMID:19729050|RGD:2315752
Biological Process	GO:0030336	negative regulation of cell migration	Acan	IDA		Rat	PMID:8641562|RGD:2315838
Biological Process	GO:0001503	ossification	Acan	IEP		Rat	PMID:20047194|RGD:2315746
Biological Process	GO:0003151	outflow tract morphogenesis	acana	IMP	ZFIN:ZDB-CRISPR-180410-1	Zfish	PMID:28986054
Biological Process	GO:0003151	outflow tract morphogenesis	acana	IMP	ZFIN:ZDB-MRPHLNO-180410-3	Zfish	PMID:28986054
Biological Process	GO:0003151	outflow tract morphogenesis	acana	IMP	ZFIN:ZDB-MRPHLNO-180410-2	Zfish	PMID:28986054
Biological Process	GO:0030166	proteoglycan biosynthetic process	Acan	IMP	MGI:MGI:1856465	Mouse	PMID:3070812
Biological Process	GO:0010447	response to acidic pH	Acan	IEP		Rat	PMID:19133233|RGD:2315756
Biological Process	GO:0009749	response to glucose	Acan	IEP		Rat	PMID:18670337|RGD:2315758
Biological Process	GO:0009629	response to gravity	Acan	IEP		Rat	PMID:18245988|RGD:2315828
Biological Process	GO:0009612	response to mechanical stimulus	Acan	IEP		Rat	PMID:19968598|RGD:2315749
Biological Process	GO:0014070	response to organic cyclic compound	Acan	IEP		Rat	PMID:18279833|RGD:2315827
Biological Process	GO:0009314	response to radiation	Acan	IEP		Rat	PMID:19480974|RGD:2315755
Biological Process	GO:0009410	response to xenobiotic stimulus	Acan	IEP		Rat	PMID:18628692|RGD:2315759
Biological Process	GO:0021510	spinal cord development	Acan	IEP		Rat	PMID:18364019|RGD:2315810

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern