Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACAT1
  • Mouse genes Acat1
  • Rat genes Acat1
  • Zfish genes acat1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Acat1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003985	acetyl-CoA C-acetyltransferase activity	ACAT1	IDA		Human	PMID:17371050
Molecular Function	GO:0003985	acetyl-CoA C-acetyltransferase activity	ACAT1	IMP		Human	PMID:1979337
Molecular Function	GO:0003985	acetyl-CoA C-acetyltransferase activity	ACAT1	IMP		Human	PMID:8103405
Molecular Function	GO:0003985	acetyl-CoA C-acetyltransferase activity	Acat1	IDA		Mouse	PMID:7592824
Molecular Function	GO:0003985	acetyl-CoA C-acetyltransferase activity	Acat1	IDA		Mouse	PMID:12114517
Molecular Function	GO:0003985	acetyl-CoA C-acetyltransferase activity	Acat1	IDA		Rat	PMID:2478525|RGD:631716
Molecular Function	GO:0016453	C-acetyltransferase activity	ACAT1	IDA		Human	PMID:17371050
Molecular Function	GO:0034736	cholesterol O-acyltransferase activity	ACAT1	IDA		Human	PMID:32944968
Molecular Function	GO:0120225	coenzyme A binding	Acat1	IPI	PubChem_Compound:6816	Rat	PMID:1672610|RGD:2326099
Molecular Function	GO:0019899	enzyme binding	Acat1	IPI	RGD:2708	Rat	PMID:1684101|RGD:2326092
Molecular Function	GO:0042802	identical protein binding	Acat1	IPI	RGD:2016	Rat	PMID:11988101|RGD:2326083
Molecular Function	GO:0030955	potassium ion binding	ACAT1	IDA		Human	PMID:17371050
Cellular Component	GO:0005783	endoplasmic reticulum	ACAT1	IDA		Human	PMID:32944968
Cellular Component	GO:0070062	extracellular exosome	ACAT1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	ACAT1	HDA		Human	PMID:23533145
Cellular Component	GO:0005743	mitochondrial inner membrane	Acat1	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005759	mitochondrial matrix	Acat1	IDA		Rat	PMID:11988101|RGD:2326083
Cellular Component	GO:0005739	mitochondrion	ACAT1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	ACAT1	IDA		Human	PMID:1979337
Cellular Component	GO:0005739	mitochondrion	Acat1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Acat1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Acat1	IDA		Rat	PMID:17180682|RGD:8554417
Biological Process	GO:0006085	acetyl-CoA biosynthetic process	ACAT1	IDA		Human	PMID:17371050
Biological Process	GO:0046356	acetyl-CoA catabolic process	ACAT1	IDA		Human	PMID:17371050
Biological Process	GO:0060612	adipose tissue development	Acat1	IEP		Rat	PMID:2866764|RGD:2326101
Biological Process	GO:0007420	brain development	Acat1	IEP		Rat	PMID:4721608|RGD:2326094
Biological Process	GO:0015937	coenzyme A biosynthetic process	ACAT1	IDA		Human	PMID:17371050
Biological Process	GO:0015936	coenzyme A metabolic process	ACAT1	IDA		Human	PMID:17371050
Biological Process	GO:0006550	isoleucine catabolic process	ACAT1	IMP		Human	PMID:1979337
Biological Process	GO:0006550	isoleucine catabolic process	ACAT1	IMP		Human	PMID:8103405
Biological Process	GO:0046952	ketone body catabolic process	ACAT1	IMP		Human	PMID:1979337
Biological Process	GO:0001889	liver development	Acat1	IEP		Rat	PMID:5166591|RGD:2326169
Biological Process	GO:0072229	metanephric proximal convoluted tubule development	Acat1	IEP		Rat	PMID:7733320|RGD:2326090
Biological Process	GO:1902860	propionyl-CoA biosynthetic process	ACAT1	IDA		Human	PMID:17371050
Biological Process	GO:0009725	response to hormone	Acat1	IEP		Rat	PMID:6144148|RGD:4105445
Biological Process	GO:0014070	response to organic cyclic compound	Acat1	IEP		Rat	PMID:6489337|RGD:2326103
Biological Process	GO:0042594	response to starvation	Acat1	IEP		Rat	PMID:2985752|RGD:2326102

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern