Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACE
  • Mouse genes Ace
  • Rat genes Ace
  • Zfish genes ace
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ace

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031711	bradykinin receptor binding	ACE	IPI	UniProtKB:P30411	Human	PMID:17077303
Molecular Function	GO:0031404	chloride ion binding	ACE	IDA		Human	PMID:11432860
Molecular Function	GO:0031404	chloride ion binding	ACE	IDA		Human	PMID:12540854
Molecular Function	GO:0004175	endopeptidase activity	ACE	IDA		Human	PMID:15283675
Molecular Function	GO:0004175	endopeptidase activity	ACE	IDA		Human	PMID:18495113
Molecular Function	GO:0008238	exopeptidase activity	ACE	IDA		Human	PMID:2983326
Molecular Function	GO:1901363	heterocyclic compound binding	Ace	IDA		Rat	PMID:7620708|RGD:8142376
Molecular Function	GO:0070573	metallodipeptidase activity	ACE	EXP		Human	PMID:1848554
Molecular Function	GO:0070573	metallodipeptidase activity	ACE	EXP		Human	PMID:1851160
Molecular Function	GO:0070573	metallodipeptidase activity	ACE	EXP		Human	PMID:20011602
Molecular Function	GO:0070573	metallodipeptidase activity	ACE	EXP		Human	PMID:2846041
Molecular Function	GO:0070573	metallodipeptidase activity	ACE	IDA		Human	PMID:7961923
Molecular Function	GO:0004222	metalloendopeptidase activity	ACE	IDA		Human	PMID:6208535
Molecular Function	GO:0004222	metalloendopeptidase activity	ACE	IDA		Human	PMID:7683654
Molecular Function	GO:0008237	metallopeptidase activity	ACE	IDA		Human	PMID:1320019
Molecular Function	GO:0008237	metallopeptidase activity	ACE	IDA		Human	PMID:1668266
Molecular Function	GO:0008237	metallopeptidase activity	ACE	IDA		Human	PMID:17077303
Molecular Function	GO:0008237	metallopeptidase activity	ACE	IDA		Human	PMID:2849100
Molecular Function	GO:0008237	metallopeptidase activity	Ace	IDA		Mouse	MGI:MGI:3793932|PMID:11303049
Molecular Function	GO:0008237	metallopeptidase activity	Ace	IMP		Rat	PMID:11299220|RGD:7401264
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	ACE	IPI	UniProtKB:P45983	Human	PMID:14615289
Molecular Function	GO:0031434	mitogen-activated protein kinase kinase binding	ACE	IPI	UniProtKB:O14733	Human	PMID:14615289
Molecular Function	GO:0008233	peptidase activity	ACE	IDA		Human	PMID:11604391
Molecular Function	GO:0008233	peptidase activity	ACE	IDA		Human	PMID:16154999
Molecular Function	GO:0008233	peptidase activity	ACE	IDA		Human	PMID:18077343
Molecular Function	GO:0008233	peptidase activity	Ace	IMP	MGI:MGI:1857115	Mouse	PMID:9231832
Molecular Function	GO:0008233	peptidase activity	Ace	IDA		Rat	PMID:12500972|RGD:152025518
Molecular Function	GO:0008233	peptidase activity	Ace	IDA		Rat	PMID:18077343|RGD:152025530
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	ACE	IDA		Human	PMID:11432860
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	ACE	IDA		Human	PMID:1320019
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	ACE	IDA		Human	PMID:15283675
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	ACE	IDA		Human	PMID:1668266
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	ACE	IDA		Human	PMID:17077303
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	ACE	IDA		Human	PMID:1851160
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	ACE	IDA		Human	PMID:19773553
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	ACE	IDA		Human	PMID:20826823
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	ACE	IDA		Human	PMID:26403559
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	ACE	IDA		Human	PMID:2849100
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	ACE	IDA		Human	PMID:4322742
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	ACE	IDA		Human	PMID:6055465
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	ACE	IDA		Human	PMID:6208535
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	ACE	IDA		Human	PMID:6270633
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	ACE	IDA		Human	PMID:656131
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	ACE	IDA		Human	PMID:7683654
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	ACE	IDA		Human	PMID:7876104
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	ACE	IDA		Human	PMID:8257427
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	Ace	IDA		Mouse	MGI:MGI:7260092|PMID:35201898
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	Ace	IDA		Mouse	MGI:MGI:3793932|PMID:11303049
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	Ace	IMP		Mouse	MGI:MGI:7294375|PMID:16270063
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	Ace	IDA		Rat	PMID:20487892|RGD:152025527
Molecular Function	GO:0008241	peptidyl-dipeptidase activity	Ace	IDA		Rat	PMID:8292044|RGD:1298871
Molecular Function	GO:0005515	protein binding	Ace	IPI	PR:E9Q9D5	Mouse	PMID:23055941
Molecular Function	GO:0008240	tripeptidyl-peptidase activity	ACE	IDA		Human	PMID:2983326
Molecular Function	GO:0008270	zinc ion binding	ACE	IDA		Human	PMID:12540854
Cellular Component	GO:0009925	basal plasma membrane	Ace	IDA		Rat	PMID:2841539|RGD:8157610
Cellular Component	GO:0031526	brush border membrane	Ace	IDA		Rat	PMID:2827504|RGD:8142378
Cellular Component	GO:0005737	cytoplasm	Ace	IDA		Mouse	MGI:MGI:5582870|PMID:23535237
Cellular Component	GO:0005768	endosome	ACE	IDA		Human	PMID:17077303
Cellular Component	GO:0009897	external side of plasma membrane	ACE	IDA		Human	PMID:9449382
Cellular Component	GO:0070062	extracellular exosome	ACE	IDA		Human	PMID:15326289
Cellular Component	GO:0070062	extracellular exosome	ACE	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	ACE	IDA		Human	PMID:21082674
Cellular Component	GO:0070062	extracellular exosome	ACE	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	ACE	IDA		Human	PMID:11274151
Cellular Component	GO:0005615	extracellular space	ACE	IDA		Human	PMID:15283675
Cellular Component	GO:0005615	extracellular space	ACE	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	ACE	IDA		Human	PMID:1668266
Cellular Component	GO:0005615	extracellular space	ACE	IDA		Human	PMID:4322742
Cellular Component	GO:0005615	extracellular space	Ace	IDA		Rat	PMID:19307186|RGD:2313695
Cellular Component	GO:0005764	lysosome	ACE	IDA		Human	PMID:11076943
Cellular Component	GO:0005886	plasma membrane	ACE	IDA		Human	PMID:17077303
Cellular Component	GO:0005886	plasma membrane	Ace	IDA		Mouse	MGI:MGI:5582870|PMID:23535237
Cellular Component	GO:0005886	plasma membrane	Ace	IDA		Rat	PMID:3031366|RGD:2325212
Cellular Component	GO:0097225	sperm midpiece	Ace	IDA		Rat	PMID:12444051|RGD:1298874
Cellular Component	GO:0031982	vesicle	Ace	IDA		Rat	PMID:2841539|RGD:8157610
Biological Process	GO:0007568	aging	Ace	IEP		Rat	PMID:22100841|RGD:6893473
Biological Process	GO:0050435	amyloid-beta metabolic process	ACE	IDA		Human	PMID:18495113
Biological Process	GO:0050435	amyloid-beta metabolic process	ACE	IDA		Human	PMID:19773553
Biological Process	GO:0060978	angiogenesis involved in coronary vascular morphogenesis	Ace	IMP		Rat	PMID:22123369|RGD:6893472
Biological Process	GO:0002003	angiotensin maturation	ACE	IDA		Human	PMID:11432860
Biological Process	GO:0002003	angiotensin maturation	ACE	IDA		Human	PMID:1320019
Biological Process	GO:0002003	angiotensin maturation	ACE	IDA		Human	PMID:4322742
Biological Process	GO:0002003	angiotensin maturation	ACE	IDA		Human	PMID:6270633
Biological Process	GO:0002003	angiotensin maturation	Ace	IDA		Mouse	MGI:MGI:3793932|PMID:11303049
Biological Process	GO:0002003	angiotensin maturation	Ace	IMP		Mouse	MGI:MGI:3040566|PMID:14757757
Biological Process	GO:0031100	animal organ regeneration	Ace	IMP		Rat	PMID:22441330|RGD:6893485
Biological Process	GO:0050482	arachidonic acid secretion	ACE	IDA		Human	PMID:17077303
Biological Process	GO:0010815	bradykinin catabolic process	ACE	IDA		Human	PMID:4322742
Biological Process	GO:0010815	bradykinin catabolic process	ACE	IDA		Human	PMID:6055465
Biological Process	GO:0010815	bradykinin catabolic process	ACE	IDA		Human	PMID:7683654
Biological Process	GO:0010815	bradykinin catabolic process	Ace	IMP		Rat	PMID:11299220|RGD:7401264
Biological Process	GO:0010815	bradykinin catabolic process	Ace	IDA		Rat	PMID:2172462|RGD:8142366
Biological Process	GO:0007420	brain development	Ace	IEP		Rat	PMID:3021286|RGD:8142371
Biological Process	GO:0071838	cell proliferation in bone marrow	Ace	IMP		Mouse	MGI:MGI:5613472|PMID:20116413
Biological Process	GO:1904045	cellular response to aldosterone	Ace	IEP		Rat	PMID:11447075|RGD:12859284
Biological Process	GO:0071333	cellular response to glucose stimulus	Ace	IEP		Rat	PMID:17626897|RGD:8142381
Biological Process	GO:0042755	eating behavior	Ace	IMP		Rat	PMID:19361967|RGD:2325227
Biological Process	GO:0009792	embryo development ending in birth or egg hatching	Ace	IMP		Rat	PMID:1784836|RGD:12879818
Biological Process	GO:0007565	female pregnancy	Ace	IEP		Rat	PMID:17977916|RGD:8548898
Biological Process	GO:0060047	heart contraction	Ace	IMP		Mouse	PMID:16585392
Biological Process	GO:0042447	hormone catabolic process	ACE	IDA		Human	PMID:6270633
Biological Process	GO:0042447	hormone catabolic process	ACE	IDA		Human	PMID:656131
Biological Process	GO:0042447	hormone catabolic process	ACE	IDA		Human	PMID:7876104
Biological Process	GO:0042447	hormone catabolic process	Ace	IDA		Mouse	MGI:MGI:3793932|PMID:11303049
Biological Process	GO:0042445	hormone metabolic process	ACE	IDA		Human	PMID:7683654
Biological Process	GO:0001822	kidney development	ACE	IMP		Human	PMID:16116425
Biological Process	GO:0001822	kidney development	Ace	IMP		Mouse	MGI:MGI:2663548|PMID:12777443
Biological Process	GO:0001822	kidney development	Ace	IMP		Mouse	MGI:MGI:3040566|PMID:14757757
Biological Process	GO:0001822	kidney development	Ace	IMP		Mouse	MGI:MGI:2158586|PMID:11723129
Biological Process	GO:0001822	kidney development	Ace	IMP	MGI:MGI:1857115	Mouse	PMID:17135368
Biological Process	GO:0001822	kidney development	Ace	IEP		Rat	PMID:7977726|RGD:8158036
Biological Process	GO:0048286	lung alveolus development	Ace	IMP		Rat	PMID:22587910|RGD:6893470
Biological Process	GO:0030324	lung development	Ace	IEP		Rat	PMID:7977726|RGD:8158036
Biological Process	GO:0008584	male gonad development	Ace	IMP		Mouse	MGI:MGI:2158586|PMID:11723129
Biological Process	GO:0008584	male gonad development	Ace	IMP		Mouse	MGI:MGI:2663548|PMID:12777443
Biological Process	GO:0008584	male gonad development	Ace	IEP		Rat	PMID:7977726|RGD:8158036
Biological Process	GO:0090281	negative regulation of calcium ion import	Ace	IMP		Rat	PMID:10506486|RGD:8142367
Biological Process	GO:1903597	negative regulation of gap junction assembly	Ace	IMP		Mouse	MGI:MGI:5607357|PMID:25017399
Biological Process	GO:0010629	negative regulation of gene expression	Ace	IMP		Mouse	MGI:MGI:5607357|PMID:25017399
Biological Process	GO:0046325	negative regulation of glucose import	Ace	IMP		Rat	PMID:24184594|RGD:11039409
Biological Process	GO:0032091	negative regulation of protein binding	Ace	IMP		Mouse	MGI:MGI:5607357|PMID:25017399
Biological Process	GO:0035814	negative regulation of renal sodium excretion	Ace	IMP		Rat	PMID:2966592|RGD:12880016
Biological Process	GO:0002446	neutrophil mediated immunity	Ace	IMP		Mouse	PMID:17082641
Biological Process	GO:0043171	peptide catabolic process	ACE	IDA		Human	PMID:15283675
Biological Process	GO:0043171	peptide catabolic process	ACE	IDA		Human	PMID:4322742
Biological Process	GO:0043171	peptide catabolic process	Ace	IDA		Rat	PMID:16148611|RGD:8157607
Biological Process	GO:0006518	peptide metabolic process	Ace	IMP		Rat	PMID:10642323|RGD:1581953
Biological Process	GO:0043065	positive regulation of apoptotic process	Ace	IMP		Rat	PMID:19301230|RGD:2311449
Biological Process	GO:0045777	positive regulation of blood pressure	Ace	IMP		Rat	PMID:17161436|RGD:12879819
Biological Process	GO:0050729	positive regulation of inflammatory response	Ace	IMP		Rat	PMID:20304959|RGD:2325219
Biological Process	GO:0050769	positive regulation of neurogenesis	Ace	IMP		Rat	PMID:20122169|RGD:2325223
Biological Process	GO:2000170	positive regulation of peptidyl-cysteine S-nitrosylation	Ace	IMP		Mouse	MGI:MGI:5607357|PMID:25017399
Biological Process	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	Ace	IMP		Mouse	MGI:MGI:5607357|PMID:25017399
Biological Process	GO:0032092	positive regulation of protein binding	Ace	IMP		Mouse	MGI:MGI:5607357|PMID:25017399
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	Ace	IMP		Mouse	MGI:MGI:5607357|PMID:25017399
Biological Process	GO:0003084	positive regulation of systemic arterial blood pressure	Ace	IMP	MGI:MGI:1857115	Mouse	PMID:9231832
Biological Process	GO:0003084	positive regulation of systemic arterial blood pressure	Ace	IMP	MGI:MGI:1857115	Mouse	PMID:17135368
Biological Process	GO:0003084	positive regulation of systemic arterial blood pressure	Ace	IMP		Rat	PMID:10506486|RGD:8142367
Biological Process	GO:0045907	positive regulation of vasoconstriction	Ace	IMP		Rat	PMID:17161436|RGD:12879819
Biological Process	GO:0010608	post-transcriptional regulation of gene expression	Ace	IMP		Mouse	MGI:MGI:5607357|PMID:25017399
Biological Process	GO:0060177	regulation of angiotensin metabolic process	ACE	IDA		Human	PMID:1851160
Biological Process	GO:0008217	regulation of blood pressure	Ace	IMP		Mouse	MGI:MGI:3040566|PMID:14757757
Biological Process	GO:0008217	regulation of blood pressure	Ace	IDA		Mouse	MGI:MGI:3793932|PMID:11303049
Biological Process	GO:0008217	regulation of blood pressure	Ace	IMP		Mouse	MGI:MGI:2663548|PMID:12777443
Biological Process	GO:0008217	regulation of blood pressure	Ace	IMP		Mouse	MGI:MGI:2158586|PMID:11723129
Biological Process	GO:0008217	regulation of blood pressure	Ace	IDA		Rat	PMID:1750504|RGD:8553744
Biological Process	GO:1902033	regulation of hematopoietic stem cell proliferation	Ace	IMP		Mouse	MGI:MGI:5613472|PMID:20116413
Biological Process	GO:0014910	regulation of smooth muscle cell migration	Ace	IDA		Rat	PMID:1750504|RGD:8553744
Biological Process	GO:0048167	regulation of synaptic plasticity	Ace	IDA		Mouse	MGI:MGI:7260092|PMID:35201898
Biological Process	GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin	ACE	IMP		Human	PMID:174834
Biological Process	GO:0071548	response to dexamethasone	Ace	IEP		Rat	PMID:1659346|RGD:8157606
Biological Process	GO:0001666	response to hypoxia	Ace	IEP		Rat	PMID:14527966|RGD:1358270
Biological Process	GO:0034616	response to laminar fluid shear stress	Ace	IEP		Rat	PMID:9048650|RGD:8142369
Biological Process	GO:0032496	response to lipopolysaccharide	Ace	IMP		Rat	PMID:19114890|RGD:2325231
Biological Process	GO:0031667	response to nutrient levels	Ace	IEP		Rat	PMID:18389998|RGD:2325234
Biological Process	GO:0097066	response to thyroid hormone	Ace	IEP		Rat	PMID:1659346|RGD:8157606
Biological Process	GO:0009410	response to xenobiotic stimulus	Ace	IEP		Rat	PMID:9495881|RGD:8142365
Biological Process	GO:0019233	sensory perception of pain	Ace	IMP		Rat	PMID:18555989|RGD:2325233
Biological Process	GO:0007283	spermatogenesis	Ace	IMP	MGI:MGI:1857115	Mouse	PMID:17135368
Biological Process	GO:0010814	substance P catabolic process	ACE	IDA		Human	PMID:6208535
Biological Process	GO:0042310	vasoconstriction	Ace	IMP		Rat	PMID:20204775|RGD:2325222

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern