Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACKR3
  • Mouse genes Ackr3
  • Rat genes Ackr3
  • Zfish genes ackr3a,ackr3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ackr3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019958	C-X-C chemokine binding	ACKR3	IMP		Human	PMID:22300987
Molecular Function	GO:0019958	C-X-C chemokine binding	ACKR3	IMP		Human	PMID:31211835
Molecular Function	GO:0016494	C-X-C chemokine receptor activity	ACKR3	IMP		Human	PMID:20388803
Molecular Function	GO:0019956	chemokine binding	ackr3b	IMP	ZFIN:ZDB-MRPHLNO-080725-5	Zfish	PMID:18267076
Molecular Function	GO:0005515	protein binding	ACKR3	IPI	UniProtKB:P61073	Human	PMID:19380869
Molecular Function	GO:0005515	protein binding	ACKR3	IPI	UniProtKB:P61073	Human	PMID:21730065
Molecular Function	GO:0005515	protein binding	ACKR3	IPI	UniProtKB:P32121	Human	PMID:22300987
Molecular Function	GO:0005515	protein binding	ACKR3	IPI	UniProtKB:P32121	Human	PMID:22457824
Molecular Function	GO:0005515	protein binding	ACKR3	IPI	UniProtKB:P49407	Human	PMID:22457824
Molecular Function	GO:0005515	protein binding	ACKR3	IPI	UniProtKB:P61073	Human	PMID:25775528
Molecular Function	GO:0005515	protein binding	ACKR3	IPI	UniProtKB:P61073	Human	PMID:27331810
Molecular Function	GO:0005515	protein binding	ACKR3	IPI	UniProtKB:P61073	Human	PMID:28862946
Molecular Function	GO:0005515	protein binding	ACKR3	IPI	UniProtKB:P37288	Human	PMID:29386406
Molecular Function	GO:0005515	protein binding	ACKR3	IPI	UniProtKB:P61073	Human	PMID:29386406
Molecular Function	GO:0005044	scavenger receptor activity	ACKR3	IMP		Human	PMID:22300987
Cellular Component	GO:0009986	cell surface	ACKR3	IDA		Human	PMID:22457824
Cellular Component	GO:0005905	clathrin-coated pit	ACKR3	IDA		Human	PMID:22457824
Cellular Component	GO:0005737	cytoplasm	Ackr3	IDA		Rat	PMID:24924806|RGD:11352662
Cellular Component	GO:0005768	endosome	ACKR3	IDA		Human	PMID:22300987
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ACKR3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Ackr3	IDA		Rat	PMID:24924806|RGD:11352662
Cellular Component	GO:0005886	plasma membrane	ACKR3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ACKR3	IDA		Human	PMID:22300987
Cellular Component	GO:0005886	plasma membrane	ACKR3	IDA		Human	PMID:31211835
Cellular Component	GO:0005886	plasma membrane	Ackr3	IDA		Rat	PMID:24924806|RGD:11352662
Biological Process	GO:0001525	angiogenesis	ackr3b	IMP	ZFIN:ZDB-MRPHLNO-071105-1,ZFIN:ZDB-MRPHLNO-071105-2	Zfish	PMID:17898181
Biological Process	GO:0070098	chemokine-mediated signaling pathway	ACKR3	IMP		Human	PMID:20388803
Biological Process	GO:0006935	chemotaxis	ackr3b	IGI	ZFIN:ZDB-GENO-100507-5,ZFIN:ZDB-MRPHLNO-140205-5,ZFIN:ZDB-MRPHLNO-140205-6	Zfish	PMID:24119842
Biological Process	GO:0006935	chemotaxis	ackr3b	IMP	ZFIN:ZDB-GENO-100507-5	Zfish	PMID:24119842
Biological Process	GO:0006935	chemotaxis	ackr3b	IGI	ZFIN:ZDB-GENO-140207-11,ZFIN:ZDB-MRPHLNO-140205-5,ZFIN:ZDB-MRPHLNO-140205-6	Zfish	PMID:24119842
Biological Process	GO:0006935	chemotaxis	ackr3a	IGI	ZFIN:ZDB-GENO-100507-5,ZFIN:ZDB-MRPHLNO-140205-5,ZFIN:ZDB-MRPHLNO-140205-6	Zfish	PMID:24119842
Biological Process	GO:0006935	chemotaxis	ackr3a	IGI	ZFIN:ZDB-GENO-140207-11,ZFIN:ZDB-MRPHLNO-140205-5,ZFIN:ZDB-MRPHLNO-140205-6	Zfish	PMID:24119842
Biological Process	GO:0006935	chemotaxis	ackr3a	IMP	ZFIN:ZDB-MRPHLNO-140205-5,ZFIN:ZDB-MRPHLNO-140205-6	Zfish	PMID:24119842
Biological Process	GO:0008354	germ cell migration	ackr3b	IMP	ZFIN:ZDB-MRPHLNO-080725-5	Zfish	PMID:18267076
Biological Process	GO:0008285	negative regulation of cell population proliferation	Ackr3	IGI	MGI:MGI:103556,MGI:MGI:1341264	Mouse	PMID:22956548
Biological Process	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ACKR3	IMP		Human	PMID:20388803
Biological Process	GO:0001764	neuron migration	ackr3b	IMP	ZFIN:ZDB-GENO-100507-5	Zfish	PMID:23382464
Biological Process	GO:0021557	oculomotor nerve development	ACKR3	IMP		Human	PMID:31211835
Biological Process	GO:0021557	oculomotor nerve development	Ackr3	IMP		Mouse	MGI:MGI:6391997|PMID:31211835
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ACKR3	IMP		Human	PMID:22300987
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Ackr3	IGI	MGI:MGI:1341264,MGI:MGI:98397	Mouse	PMID:22956548
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Ackr3	IGI	MGI:MGI:1341264,MGI:MGI:95294	Mouse	PMID:22956548
Biological Process	GO:1905322	positive regulation of mesenchymal stem cell migration	Ackr3	IMP		Rat	PMID:24924806|RGD:11352662
Biological Process	GO:0048920	posterior lateral line neuromast primordium migration	ackr3b	IGI	ZFIN:ZDB-GENO-140207-11,ZFIN:ZDB-MRPHLNO-140205-5,ZFIN:ZDB-MRPHLNO-140205-6	Zfish	PMID:24119842
Biological Process	GO:0048920	posterior lateral line neuromast primordium migration	ackr3b	IMP	ZFIN:ZDB-GENO-100507-5	Zfish	PMID:24119842
Biological Process	GO:0048920	posterior lateral line neuromast primordium migration	ackr3b	IGI	ZFIN:ZDB-MRPHLNO-050318-7,ZFIN:ZDB-MRPHLNO-100512-6	Zfish	PMID:17394634
Biological Process	GO:0048920	posterior lateral line neuromast primordium migration	ackr3b	IMP	ZFIN:ZDB-MRPHLNO-100512-6	Zfish	PMID:17570670
Biological Process	GO:0048920	posterior lateral line neuromast primordium migration	ackr3b	IGI	ZFIN:ZDB-GENO-100507-5,ZFIN:ZDB-MRPHLNO-140205-5,ZFIN:ZDB-MRPHLNO-140205-6	Zfish	PMID:24119842
Biological Process	GO:0048920	posterior lateral line neuromast primordium migration	ackr3b	IMP	ZFIN:ZDB-MRPHLNO-100427-5	Zfish	PMID:17570670
Biological Process	GO:0048920	posterior lateral line neuromast primordium migration	ackr3b	IMP	ZFIN:ZDB-MRPHLNO-100512-6	Zfish	PMID:17394634
Biological Process	GO:0048920	posterior lateral line neuromast primordium migration	ackr3b	IGI	ZFIN:ZDB-GENO-030312-1,ZFIN:ZDB-MRPHLNO-100512-6	Zfish	PMID:17570670
Biological Process	GO:0048920	posterior lateral line neuromast primordium migration	ackr3b	IGI	ZFIN:ZDB-MRPHLNO-081217-1,ZFIN:ZDB-MRPHLNO-100512-6	Zfish	PMID:17394634
Biological Process	GO:0048920	posterior lateral line neuromast primordium migration	ackr3a	IGI	ZFIN:ZDB-GENO-100507-5,ZFIN:ZDB-MRPHLNO-140205-5,ZFIN:ZDB-MRPHLNO-140205-6	Zfish	PMID:24119842
Biological Process	GO:0048920	posterior lateral line neuromast primordium migration	ackr3a	IMP	ZFIN:ZDB-MRPHLNO-140205-5,ZFIN:ZDB-MRPHLNO-140205-6	Zfish	PMID:24119842
Biological Process	GO:0048920	posterior lateral line neuromast primordium migration	ackr3a	IGI	ZFIN:ZDB-GENO-140207-11,ZFIN:ZDB-MRPHLNO-140205-5,ZFIN:ZDB-MRPHLNO-140205-6	Zfish	PMID:24119842
Biological Process	GO:0031623	receptor internalization	ACKR3	IMP		Human	PMID:22300987
Biological Process	GO:0031623	receptor internalization	ACKR3	IMP		Human	PMID:22457824
Biological Process	GO:0021730	trigeminal sensory nucleus development	ackr3b	IMP	ZFIN:ZDB-GENO-100507-5	Zfish	PMID:23382464
Biological Process	GO:0021730	trigeminal sensory nucleus development	ackr3b	IGI	ZFIN:ZDB-GENO-141204-1	Zfish	PMID:23382464
Biological Process	GO:0001570	vasculogenesis	ackr3b	IMP	ZFIN:ZDB-MRPHLNO-071105-1,ZFIN:ZDB-MRPHLNO-071105-2	Zfish	PMID:17898181

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern