Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACO1
  • Mouse genes Aco1
  • Rat genes Aco1
  • Zfish genes aco1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Aco1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051538	3 iron, 4 sulfur cluster binding	ACO1	IMP		Human	PMID:1281544
Molecular Function	GO:0051539	4 iron, 4 sulfur cluster binding	ACO1	IMP		Human	PMID:1281544
Molecular Function	GO:0051539	4 iron, 4 sulfur cluster binding	ACO1	IDA		Human	PMID:16407072
Molecular Function	GO:0003994	aconitate hydratase activity	ACO1	IMP		Human	PMID:1281544
Molecular Function	GO:0003994	aconitate hydratase activity	ACO1	IDA		Human	PMID:1946430
Molecular Function	GO:0003994	aconitate hydratase activity	ACO1	IDA		Human	PMID:8041788
Molecular Function	GO:0003994	aconitate hydratase activity	Aco1	IDA		Mouse	PMID:14726953
Molecular Function	GO:0003994	aconitate hydratase activity	Aco1	IDA		Mouse	PMID:15604406
Molecular Function	GO:0003994	aconitate hydratase activity	Aco1	IDA		Rat	PMID:11264001|RGD:1642739
Molecular Function	GO:0003994	aconitate hydratase activity	Aco1	IDA		Rat	PMID:9092825|RGD:1642740
Molecular Function	GO:0030350	iron-responsive element binding	ACO1	IMP		Human	PMID:1281544
Molecular Function	GO:0030350	iron-responsive element binding	ACO1	IMP		Human	PMID:23891004
Molecular Function	GO:0030350	iron-responsive element binding	ACO1	IDA		Human	PMID:8041788
Molecular Function	GO:0030350	iron-responsive element binding	Aco1	IDA		Mouse	PMID:15629469
Molecular Function	GO:0030350	iron-responsive element binding	Aco1	IDA		Mouse	PMID:14726953
Molecular Function	GO:0030350	iron-responsive element binding	Aco1	IDA		Mouse	PMID:15604406
Molecular Function	GO:0030350	iron-responsive element binding	Aco1	IDA		Mouse	PMID:8262972
Molecular Function	GO:0030350	iron-responsive element binding	Aco1	IDA		Rat	PMID:12672910|RGD:1642738
Molecular Function	GO:0030350	iron-responsive element binding	Aco1	IDA		Rat	PMID:15086359|RGD:1642737
Molecular Function	GO:0030350	iron-responsive element binding	Aco1	IDA		Rat	PMID:9092825|RGD:1642740
Molecular Function	GO:0051536	iron-sulfur cluster binding	Aco1	IDA		Rat	PMID:9092825|RGD:1642740
Molecular Function	GO:0048027	mRNA 5'-UTR binding	Aco1	IDA		Rat	PMID:9092825|RGD:1642740
Molecular Function	GO:0005515	protein binding	ACO1	IPI	UniProtKB:Q9UKA1	Human	PMID:19762596
Molecular Function	GO:0005515	protein binding	ACO1	IPI	UniProtKB:Q9UKA1	Human	PMID:19762597
Molecular Function	GO:0003723	RNA binding	ACO1	IDA		Human	PMID:1946430
Molecular Function	GO:0003723	RNA binding	Aco1	IDA		Rat	PMID:1527027|RGD:633751
Cellular Component	GO:0005737	cytoplasm	ACO1	IMP		Human	PMID:1281544
Cellular Component	GO:0005737	cytoplasm	Aco1	IDA		Mouse	PMID:8262972
Cellular Component	GO:0005829	cytosol	ACO1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	ACO1	IDA		Human	PMID:1281544
Cellular Component	GO:0005829	cytosol	ACO1	IDA		Human	PMID:16527810
Cellular Component	GO:0005829	cytosol	Aco1	IDA		Mouse	PMID:16144863
Cellular Component	GO:0005829	cytosol	Aco1	IDA		Mouse	PMID:14726953
Cellular Component	GO:0005829	cytosol	Aco1	IDA		Rat	PMID:12672910|RGD:1642738
Cellular Component	GO:0005829	cytosol	Aco1	IDA		Rat	PMID:9092825|RGD:1642740
Cellular Component	GO:0005783	endoplasmic reticulum	ACO1	IDA		Human	PMID:16144863
Cellular Component	GO:0005783	endoplasmic reticulum	Aco1	IDA		Rat	PMID:16144863|RGD:1642730
Cellular Component	GO:0070062	extracellular exosome	ACO1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	ACO1	HDA		Human	PMID:23533145
Cellular Component	GO:0005794	Golgi apparatus	ACO1	IDA		Human	PMID:16144863
Cellular Component	GO:0005794	Golgi apparatus	Aco1	IDA		Rat	PMID:16144863|RGD:1642730
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Aco1	IDA		Rat	PMID:16144863|RGD:1642730
Cellular Component	GO:0005739	mitochondrion	ACO1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Aco1	HDA		Mouse	PMID:18614015
Biological Process	GO:0006101	citrate metabolic process	ACO1	IMP		Human	PMID:1281544
Biological Process	GO:0006101	citrate metabolic process	ACO1	IDA		Human	PMID:16527810
Biological Process	GO:0006101	citrate metabolic process	ACO1	IDA		Human	PMID:8041788
Biological Process	GO:0050892	intestinal absorption	Aco1	IGI	MGI:MGI:1928268	Mouse	PMID:18177727
Biological Process	GO:0006879	intracellular iron ion homeostasis	Aco1	IGI	MGI:MGI:1928268	Mouse	PMID:14726953
Biological Process	GO:0006879	intracellular iron ion homeostasis	Aco1	IMP	MGI:MGI:3029223	Mouse	PMID:14726953
Biological Process	GO:0006879	intracellular iron ion homeostasis	Aco1	IDA		Rat	PMID:15086359|RGD:1642737
Biological Process	GO:0001889	liver development	Aco1	IEP		Rat	PMID:755797|RGD:11552585
Biological Process	GO:0009791	post-embryonic development	Aco1	IGI	MGI:MGI:1928268	Mouse	PMID:18177727
Biological Process	GO:0010468	regulation of gene expression	Aco1	IGI	MGI:MGI:1928268	Mouse	PMID:18177727
Biological Process	GO:0006417	regulation of translation	Aco1	IMP	MGI:MGI:3029223	Mouse	PMID:14726953
Biological Process	GO:0010040	response to iron(II) ion	ACO1	IDA		Human	PMID:8041788

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern