Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACO2
  • Mouse genes Aco2
  • Rat genes Aco2
  • Zfish genes aco2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Aco2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051538	3 iron, 4 sulfur cluster binding	Aco2	IDA		Rat	PMID:14674759|RGD:2306852
Molecular Function	GO:0051539	4 iron, 4 sulfur cluster binding	Aco2	IDA		Rat	PMID:14674759|RGD:2306852
Molecular Function	GO:0003994	aconitate hydratase activity	ACO2	EXP		Human	PMID:1052766
Molecular Function	GO:0003994	aconitate hydratase activity	Aco2	IDA		Mouse	PMID:32212192
Molecular Function	GO:0003994	aconitate hydratase activity	Aco2	IDA		Mouse	PMID:15317809
Molecular Function	GO:0003994	aconitate hydratase activity	Aco2	IDA		Mouse	PMID:17322295
Molecular Function	GO:0003994	aconitate hydratase activity	Aco2	IDA		Rat	PMID:12139479|RGD:632269
Molecular Function	GO:0003994	aconitate hydratase activity	Aco2	IDA		Rat	PMID:14674759|RGD:2306852
Molecular Function	GO:0003994	aconitate hydratase activity	Aco2	IDA		Rat	PMID:9712727|RGD:2306877
Molecular Function	GO:0005506	iron ion binding	ACO2	IDA		Human	PMID:9630632
Molecular Function	GO:0005515	protein binding	Aco2	IPI	RGD:1565754	Rat	PMID:15840721|RGD:2306801
Cellular Component	GO:0005759	mitochondrial matrix	Aco2	IDA		Mouse	PMID:32212192
Cellular Component	GO:0005739	mitochondrion	ACO2	HDA		Human	PMID:20833797
Cellular Component	GO:0005739	mitochondrion	Aco2	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Aco2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Aco2	IDA		Mouse	PMID:17322295
Cellular Component	GO:0005739	mitochondrion	Aco2	IDA		Rat	PMID:14674759|RGD:2306852
Cellular Component	GO:0005739	mitochondrion	Aco2	IDA		Rat	PMID:9712727|RGD:2306877
Cellular Component	GO:0043209	myelin sheath	Aco2	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Biological Process	GO:0006101	citrate metabolic process	ACO2	IDA		Human	PMID:9630632
Biological Process	GO:0006101	citrate metabolic process	Aco2	IDA		Rat	PMID:14674759|RGD:2306852
Biological Process	GO:0006101	citrate metabolic process	Aco2	IDA		Rat	PMID:9712727|RGD:2306877
Biological Process	GO:0006102	isocitrate metabolic process	Aco2	IDA		Rat	PMID:14674759|RGD:2306852
Biological Process	GO:0006102	isocitrate metabolic process	Aco2	IDA		Rat	PMID:9712727|RGD:2306877
Biological Process	GO:0001889	liver development	Aco2	IEP		Rat	PMID:755797|RGD:11552585
Biological Process	GO:0035900	response to isolation stress	Aco2	IEP		Rat	PMID:19616040|RGD:2314839
Biological Process	GO:0006099	tricarboxylic acid cycle	ACO2	IDA		Human	PMID:9630632
Biological Process	GO:0006099	tricarboxylic acid cycle	Aco2	IGI	MGI:MGI:88529	Mouse	PMID:32212192
Biological Process	GO:0006099	tricarboxylic acid cycle	Aco2	IDA		Rat	PMID:9712727|RGD:2306877

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern