Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACR
  • Mouse genes Acr
  • Rat genes Acr
  • Zfish genes tmprss12
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Acr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005537	mannose binding	ACR	IDA		Human	PMID:15950652
Molecular Function	GO:0008233	peptidase activity	Acr	IMP	MGI:MGI:2429958	Mouse	PMID:9041140
Molecular Function	GO:0008233	peptidase activity	Acr	IMP	MGI:MGI:2180087	Mouse	PMID:7989357
Molecular Function	GO:0005515	protein binding	ACR	IPI	UniProtKB:P21754	Human	PMID:15950651
Molecular Function	GO:0005515	protein binding	ACR	IPI	UniProtKB:Q05996	Human	PMID:15950651
Molecular Function	GO:0005515	protein binding	ACR	IPI	UniProtKB:Q12836	Human	PMID:15950651
Molecular Function	GO:0005515	protein binding	ACR	IPI	UniProtKB:P05154	Human	PMID:7521127
Molecular Function	GO:0005515	protein binding	Acr	IPI	PR:P20239	Mouse	PMID:11739644
Molecular Function	GO:0005515	protein binding	Acr	IPI	PR:P10761	Mouse	PMID:11739644
Molecular Function	GO:0004252	serine-type endopeptidase activity	ACR	IDA		Human	PMID:6802470
Cellular Component	GO:0001669	acrosomal vesicle	Acr	IDA		Mouse	PMID:7798216
Cellular Component	GO:0001669	acrosomal vesicle	Acr	IDA		Rat	PMID:8601690|RGD:1598715
Cellular Component	GO:0005798	Golgi-associated vesicle	Acr	IDA		Rat	PMID:8601690|RGD:1598715
Cellular Component	GO:0005634	nucleus	ACR	HDA		Human	PMID:21630459
Cellular Component	GO:0032991	protein-containing complex	ACR	IDA		Human	PMID:7521127
Biological Process	GO:0002077	acrosome matrix dispersal	Acr	IMP		Rat	PMID:28859281|RGD:13464336
Biological Process	GO:0007340	acrosome reaction	ACR	IMP		Human	PMID:2550339
Biological Process	GO:0007190	activation of adenylate cyclase activity	ACR	IDA		Human	PMID:3880736
Biological Process	GO:0007339	binding of sperm to zona pellucida	Acr	IGI	MGI:MGI:98785	Mouse	PMID:15685642
Biological Process	GO:0007339	binding of sperm to zona pellucida	Acr	IGI	MGI:MGI:1888530	Mouse	PMID:15685642
Biological Process	GO:0007339	binding of sperm to zona pellucida	Acr	IGI	MGI:MGI:96945	Mouse	PMID:15685642
Biological Process	GO:0007341	penetration of zona pellucida	Acr	IGI	MGI:MGI:96945	Mouse	PMID:15051954
Biological Process	GO:0007341	penetration of zona pellucida	Acr	IMP	MGI:MGI:2180087	Mouse	PMID:7989357
Biological Process	GO:0007341	penetration of zona pellucida	Acr	IMP	MGI:MGI:2429958	Mouse	PMID:9041140
Biological Process	GO:0007341	penetration of zona pellucida	Acr	IMP		Rat	PMID:28859281|RGD:13464336
Biological Process	GO:0030163	protein catabolic process	Acr	IMP		Rat	PMID:28859281|RGD:13464336
Biological Process	GO:0048545	response to steroid hormone	Acr	IDA		Rat	PMID:9838878|RGD:1598714
Biological Process	GO:0007338	single fertilization	Acr	IMP		Mouse	MGI:MGI:3577815|PMID:15685642

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern