Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACSL4
  • Mouse genes Acsl4
  • Rat genes Acsl4
  • Zfish genes acsl4a,acsl4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Acsl4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0047676	arachidonate-CoA ligase activity	ACSL4	IDA		Human	PMID:9598324
Molecular Function	GO:0047676	arachidonate-CoA ligase activity	Acsl4	IDA		Rat	PMID:28209804|RGD:14697717
Molecular Function	GO:0004467	long-chain fatty acid-CoA ligase activity	ACSL4	IDA		Human	PMID:10669417
Molecular Function	GO:0004467	long-chain fatty acid-CoA ligase activity	ACSL4	EXP		Human	PMID:11889465
Molecular Function	GO:0004467	long-chain fatty acid-CoA ligase activity	ACSL4	EXP		Human	PMID:12525535
Molecular Function	GO:0004467	long-chain fatty acid-CoA ligase activity	ACSL4	IMP		Human	PMID:22633490
Molecular Function	GO:0004467	long-chain fatty acid-CoA ligase activity	ACSL4	IDA		Human	PMID:24269233
Molecular Function	GO:0004467	long-chain fatty acid-CoA ligase activity	Acsl4	IDA		Mouse	PMID:23159612
Molecular Function	GO:0004467	long-chain fatty acid-CoA ligase activity	Acsl4	IMP		Rat	PMID:23766516|RGD:14695075
Molecular Function	GO:0004467	long-chain fatty acid-CoA ligase activity	Acsl4	IDA		Rat	PMID:28209804|RGD:14697717
Molecular Function	GO:0004467	long-chain fatty acid-CoA ligase activity	Acsl4	IDA		Rat	PMID:9096315|RGD:69374
Molecular Function	GO:0031957	very long-chain fatty acid-CoA ligase activity	ACSL4	IMP		Human	PMID:11889465
Cellular Component	GO:0005737	cytoplasm	ACSL4	IDA		Human	PMID:11889465
Cellular Component	GO:0005783	endoplasmic reticulum	Acsl4	IDA		Rat	PMID:19166906|RGD:2312805
Cellular Component	GO:0070062	extracellular exosome	ACSL4	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	ACSL4	HDA		Human	PMID:20458337
Cellular Component	GO:0005811	lipid droplet	ACSL4	IDA		Human	PMID:14741744
Cellular Component	GO:0016020	membrane	ACSL4	HDA		Human	PMID:19946888
Cellular Component	GO:0044233	mitochondria-associated endoplasmic reticulum membrane	ACSL4	IDA		Human	PMID:23455425
Cellular Component	GO:0031966	mitochondrial membrane	Acsl4	IDA		Rat	PMID:12147264|RGD:2312803
Cellular Component	GO:0005739	mitochondrion	Acsl4	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Acsl4	IDA		Mouse	PMID:23159612
Cellular Component	GO:0043025	neuronal cell body	Acsl4	IDA		Rat	PMID:19166906|RGD:2312805
Cellular Component	GO:0005777	peroxisome	Acsl4	IDA		Rat	PMID:12147264|RGD:2312803
Biological Process	GO:0051216	cartilage development	acsl4b	IMP	ZFIN:ZDB-MRPHLNO-220112-1	Zfish	PMID:30264402
Biological Process	GO:0060996	dendritic spine development	Acsl4	IMP		Rat	PMID:19166906|RGD:2312805
Biological Process	GO:0009953	dorsal/ventral pattern formation	acsl4a	IMP	ZFIN:ZDB-MRPHLNO-140421-2	Zfish	PMID:24332754
Biological Process	GO:0009953	dorsal/ventral pattern formation	acsl4a	IMP	ZFIN:ZDB-MRPHLNO-140421-1	Zfish	PMID:24332754
Biological Process	GO:0060136	embryonic process involved in female pregnancy	Acsl4	IMP	MGI:MGI:2182854	Mouse	PMID:11409893
Biological Process	GO:0006631	fatty acid metabolic process	Acsl4	IDA		Rat	PMID:9096315|RGD:69374
Biological Process	GO:0015908	fatty acid transport	Acsl4	IGI	SGD:S000005844|SGD:S000004860	Rat	PMID:16466685|RGD:2312800
Biological Process	GO:0006629	lipid metabolic process	ACSL4	IDA		Human	PMID:9598324
Biological Process	GO:0001676	long-chain fatty acid metabolic process	ACSL4	IMP		Human	PMID:22633490
Biological Process	GO:0001676	long-chain fatty acid metabolic process	ACSL4	IDA		Human	PMID:24269233
Biological Process	GO:0001676	long-chain fatty acid metabolic process	Acsl4	IDA		Mouse	MGI:MGI:5469506|PMID:23159612
Biological Process	GO:0001676	long-chain fatty acid metabolic process	Acsl4	IDA		Rat	PMID:28209804|RGD:14697717
Biological Process	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process	Acsl4	IGI	SGD:S000005844|SGD:S000004860	Rat	PMID:16466685|RGD:2312800
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	acsl4a	IMP	ZFIN:ZDB-MRPHLNO-140421-1	Zfish	PMID:24332754
Biological Process	GO:0032024	positive regulation of insulin secretion	Acsl4	IMP		Rat	PMID:23766516|RGD:14695075
Biological Process	GO:1900744	regulation of p38MAPK cascade	acsl4a	IMP	ZFIN:ZDB-MRPHLNO-140421-1	Zfish	PMID:24332754
Biological Process	GO:0051896	regulation of protein kinase B signaling	acsl4a	IMP	ZFIN:ZDB-MRPHLNO-140421-1	Zfish	PMID:24332754
Biological Process	GO:0070672	response to interleukin-15	Acsl4	IEP		Rat	PMID:18239634|RGD:2312806
Biological Process	GO:0007584	response to nutrient	Acsl4	IEP		Rat	PMID:16772660|RGD:1599807
Biological Process	GO:0019432	triglyceride biosynthetic process	Acsl4	IGI	SGD:S000005844|SGD:S000004860	Rat	PMID:16466685|RGD:2312800

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern