Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACTA1
  • Mouse genes Acta1
  • Rat genes Acta1
  • Zfish genes acta1a,acta1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Acta1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	ACTA1	IPI	UniProtKB:P24855	Human	PMID:12849983
Molecular Function	GO:0005515	protein binding	ACTA1	IPI	UniProtKB:P9WIP9	Human	PMID:18835984
Molecular Function	GO:0005515	protein binding	ACTA1	IPI	UniProtKB:P17024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ACTA1	IPI	UniProtKB:Q0VD86	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ACTA1	IPI	UniProtKB:Q6XD76	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ACTA1	IPI	UniProtKB:Q6ZQX7-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ACTA1	IPI	UniProtKB:Q96PV4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ACTA1	IPI	UniProtKB:Q9H7C4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ACTA1	IPI	UniProtKB:Q9UQM7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Acta1	IPI	PR:Q9Z0G0	Mouse	PMID:15975910
Cellular Component	GO:0015629	actin cytoskeleton	ACTA1	IMP		Human	PMID:15198992
Cellular Component	GO:0005884	actin filament	ACTA1	IDA		Human	PMID:12849983
Cellular Component	GO:0072562	blood microparticle	ACTA1	HDA		Human	PMID:22516433
Cellular Component	GO:0070062	extracellular exosome	ACTA1	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	ACTA1	HDA		Human	PMID:21362503
Cellular Component	GO:0070062	extracellular exosome	ACTA1	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	ACTA1	HDA		Human	PMID:23580065
Cellular Component	GO:0030017	sarcomere	ACTA1	IDA		Human	PMID:1423520
Cellular Component	GO:0001725	stress fiber	ACTA1	IDA		Human	PMID:15198992
Cellular Component	GO:0005865	striated muscle thin filament	ACTA1	IDA		Human	PMID:15198992
Biological Process	GO:0071417	cellular response to organonitrogen compound	Acta1	IEP		Rat	PMID:16040721|RGD:1598725
Biological Process	GO:0035050	embryonic heart tube development	acta1b	IMP	ZFIN:ZDB-GENO-040520-1	Zfish	PMID:15138499
Biological Process	GO:0009991	response to extracellular stimulus	Acta1	IEP		Rat	PMID:17146758|RGD:1598717
Biological Process	GO:0010226	response to lithium ion	Acta1	IEP		Rat	PMID:12878481|RGD:1598728
Biological Process	GO:0009612	response to mechanical stimulus	Acta1	IEP		Rat	PMID:12704188|RGD:1580391
Biological Process	GO:0048545	response to steroid hormone	Acta1	IEP		Rat	PMID:14993121|RGD:1598718
Biological Process	GO:0043503	skeletal muscle fiber adaptation	Acta1	IEP		Rat	PMID:16428321|RGD:1598721
Biological Process	GO:0048741	skeletal muscle fiber development	Acta1	IDA		Mouse	MGI:MGI:78319|PMID:2731651
Biological Process	GO:0048741	skeletal muscle fiber development	acta1b	IGI	ZFIN:ZDB-GENO-180821-3,ZFIN:ZDB-MRPHLNO-180709-5	Zfish	PMID:29420541
Biological Process	GO:0048741	skeletal muscle fiber development	acta1a	IGI	ZFIN:ZDB-GENO-180821-3,ZFIN:ZDB-MRPHLNO-180709-5	Zfish	PMID:29420541
Biological Process	GO:0030240	skeletal muscle thin filament assembly	ACTA1	IMP		Human	PMID:11333380

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern