Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACTA2
  • Mouse genes Acta2
  • Rat genes Acta2
  • Zfish genes acta2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Acta2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	Acta2	IPI	PR:E9Q9D5	Mouse	PMID:23055941
Molecular Function	GO:0019901	protein kinase binding	Acta2	IPI	UniProtKB:Q5S007	Mouse	MGI:MGI:4941068|PMID:21307259
Cellular Component	GO:0015629	actin cytoskeleton	Acta2	IDA		Mouse	PMID:17882221
Cellular Component	GO:0015629	actin cytoskeleton	Acta2	IDA		Rat	PMID:8616889|RGD:8553354
Cellular Component	GO:0005604	basement membrane	Acta2	IDA		Rat	PMID:30476341|RGD:151893502
Cellular Component	GO:0005737	cytoplasm	ACTA2	IDA		Human	PMID:11927518
Cellular Component	GO:0005737	cytoplasm	ACTA2	IDA		Human	PMID:12355421
Cellular Component	GO:0005737	cytoplasm	ACTA2	IDA		Human	PMID:17464107
Cellular Component	GO:0005737	cytoplasm	Acta2	IDA		Mouse	PMID:17717145
Cellular Component	GO:0005737	cytoplasm	Acta2	IDA		Mouse	PMID:29636669
Cellular Component	GO:0005737	cytoplasm	Acta2	IDA		Mouse	PMID:35087169
Cellular Component	GO:0005737	cytoplasm	Acta2	IDA		Mouse	PMID:21708977
Cellular Component	GO:0005737	cytoplasm	Acta2	IDA		Rat	PMID:15972885|RGD:12879443
Cellular Component	GO:0005856	cytoskeleton	Acta2	IDA		Mouse	PMID:16989802
Cellular Component	GO:0070062	extracellular exosome	ACTA2	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	ACTA2	HDA		Human	PMID:23580065
Cellular Component	GO:0031514	motile cilium	Acta2	IDA		Mouse	PMID:35087169
Cellular Component	GO:0032991	protein-containing complex	ACTA2	IDA		Human	PMID:18468998
Cellular Component	GO:0030485	smooth muscle contractile fiber	Acta2	IDA		Mouse	PMID:18332105
Cellular Component	GO:0001725	stress fiber	Acta2	IDA		Rat	PMID:24204762|RGD:12879446
Biological Process	GO:0008015	blood circulation	acta2	IMP	ZFIN:ZDB-MRPHLNO-101220-1	Zfish	PMID:26893369
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Acta2	IEP		Rat	PMID:17043753|RGD:2292410
Biological Process	GO:0072144	glomerular mesangial cell development	ACTA2	IEP		Human	PMID:17464107
Biological Process	GO:0060047	heart contraction	acta2	IMP	ZFIN:ZDB-MRPHLNO-101220-1	Zfish	PMID:26893369
Biological Process	GO:0072051	juxtaglomerular apparatus development	Acta2	IEP		Rat	PMID:30645697|RGD:155631307
Biological Process	GO:0006936	muscle contraction	Acta2	IDA		Rat	PMID:11953441|RGD:625414
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Acta2	IMP		Rat	PMID:24204762|RGD:12879446
Biological Process	GO:2000491	positive regulation of hepatic stellate cell activation	Acta2	IMP		Rat	PMID:24204762|RGD:12879446
Biological Process	GO:0061874	positive regulation of hepatic stellate cell contraction	Acta2	IMP		Rat	PMID:24204762|RGD:12879446
Biological Process	GO:0061870	positive regulation of hepatic stellate cell migration	Acta2	IMP		Rat	PMID:24204762|RGD:12879446
Biological Process	GO:0008217	regulation of blood pressure	Acta2	IMP	MGI:MGI:3665248	Mouse	PMID:11053242
Biological Process	GO:0061041	regulation of wound healing	Acta2	IMP		Rat	PMID:24204762|RGD:12879446
Biological Process	GO:0009615	response to virus	ACTA2	IEP		Human	PMID:16548883
Biological Process	GO:0014829	vascular associated smooth muscle contraction	Acta2	IMP	MGI:MGI:3665248	Mouse	PMID:11053242

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern