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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Actb

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Actb
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0042802identical protein bindingACTBIPIUniProtKB:P60709HumanPMID:16189514
Molecular FunctionGO:0042802identical protein bindingACTBIPIUniProtKB:P60709HumanPMID:17404223
Molecular FunctionGO:0042802identical protein bindingACTBIPIUniProtKB:P60709HumanPMID:18234857
Molecular FunctionGO:0042802identical protein bindingACTBIPIUniProtKB:P60709HumanPMID:19000816
Molecular FunctionGO:0042802identical protein bindingACTBIPIUniProtKB:P60709HumanPMID:20383143
Molecular FunctionGO:0042802identical protein bindingACTBIPIUniProtKB:P60709HumanPMID:21516116
Molecular FunctionGO:0042802identical protein bindingACTBIPIUniProtKB:P60709HumanPMID:25416956
Molecular FunctionGO:0042802identical protein bindingACTBIPIUniProtKB:P60709HumanPMID:25502805
Molecular FunctionGO:0042802identical protein bindingACTBIPIUniProtKB:P60709HumanPMID:25910212
Molecular FunctionGO:0042802identical protein bindingACTBIPIUniProtKB:P60709HumanPMID:29892012
Molecular FunctionGO:0042802identical protein bindingACTBIPIUniProtKB:P60709HumanPMID:31515488
Molecular FunctionGO:0042802identical protein bindingACTBIPIUniProtKB:P60709HumanPMID:32296183
Molecular FunctionGO:0019894kinesin bindingACTBIPIUniProtKB:Q8NI77HumanPMID:18680169
Molecular FunctionGO:0050998nitric-oxide synthase bindingACTBIPIUniProtKB:P29474HumanPMID:17502619
Molecular FunctionGO:0031492nucleosomal DNA bindingACTBHDAHumanPMID:16217013
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P07910HumanPMID:11687588
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q08211HumanPMID:11687588
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q96QU8HumanPMID:14592989
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P11142HumanPMID:15047060
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P63104HumanPMID:15161933
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P50402HumanPMID:15328537
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P05067HumanPMID:16049941
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P23528HumanPMID:16189514
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P60981HumanPMID:16189514
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P63261HumanPMID:16189514
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q9Y281HumanPMID:16189514
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P14598HumanPMID:16375898
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P13688HumanPMID:17192268
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q7Z460HumanPMID:17342765
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P08413HumanPMID:17404223
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P29474HumanPMID:17502619
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q92636HumanPMID:17599063
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q8N6F7HumanPMID:17823310
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P23975HumanPMID:18331289
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P37840HumanPMID:18331289
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q9WMX2:PRO_0000037551HumanPMID:18562541
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P07737HumanPMID:19000816
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P86294HumanPMID:19000816
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q8K4J6HumanPMID:19008859
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:O14950HumanPMID:19328794
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P07737HumanPMID:19338310
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P11142HumanPMID:19338310
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q8TCJ0-2HumanPMID:20473970
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P63104HumanPMID:20618440
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q9BSI4HumanPMID:21044950
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P63261HumanPMID:21516116
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q9Y281HumanPMID:21516116
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P04626HumanPMID:21555369
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P37802HumanPMID:21577206
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q78TU8HumanPMID:21969592
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P13569HumanPMID:22038833
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P31146HumanPMID:23100250
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P07237HumanPMID:24415753
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P23528HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P60981HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P63261HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q549N0HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q96HA8HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P13569HumanPMID:25712891
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P40123HumanPMID:25910212
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P63261HumanPMID:25910212
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q9Y281HumanPMID:25910212
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P13693HumanPMID:27607350
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P40123HumanPMID:28514442
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q8WTR2HumanPMID:28514442
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:O95990HumanPMID:28604741
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P83110HumanPMID:29477555
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P23528HumanPMID:29892012
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P60981HumanPMID:29892012
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P63261HumanPMID:29892012
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q96HA8HumanPMID:29892012
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P13569HumanPMID:29924966
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P63261HumanPMID:30886144
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P23528HumanPMID:31515488
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P60981HumanPMID:31515488
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P63261HumanPMID:31515488
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q08426HumanPMID:31515488
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q96HA8HumanPMID:31515488
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q9Y281HumanPMID:31515488
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P23528HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P60981HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P63261HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P78317HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q08426HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q16543HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q7KZS0HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q8WTR2HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q9Y281HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P05067HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:P42858HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingACTBIPIUniProtKB:Q9UBQ0-2HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingActbIPIUniProtKB:Q923J1MouseMGI:MGI:3613403|PMID:16407977
Molecular FunctionGO:0005515protein bindingActbIPIUniProtKB:P97792MouseMGI:MGI:3715396|PMID:17531226
Molecular FunctionGO:0005515protein bindingActbIPIUniProtKB:Q923J1MouseMGI:MGI:5644004|PMID:24855944
Molecular FunctionGO:0005515protein bindingActbIPIUniProtKB:P61809MouseMGI:MGI:3829808|PMID:19118186
Molecular FunctionGO:0005515protein bindingActbIPIUniProtKB:O41974MouseMGI:MGI:5787727|PMID:26581985
Molecular FunctionGO:0005515protein bindingActbIPIUniProtKB:O35926MouseMGI:MGI:6158991|PMID:10683146
Molecular FunctionGO:0005515protein bindingActbIPIUniProtKB:Q96A23|UniProtKB:Q99829MouseMGI:MGI:5294308|PMID:12522145
Molecular FunctionGO:0005515protein bindingActbIPIPR:Q9JIP4MousePMID:20086016
Molecular FunctionGO:0005515protein bindingActbIPIUniProtKB:Q5BJU7RatPMID:16530190|RGD:8554036
Molecular FunctionGO:0005515protein bindingActbIPIUniProtKB:B6VQA5RatPMID:16924657|RGD:8553693
Molecular FunctionGO:0005515protein bindingActbIPIRGD:3720RatPMID:24657527|RGD:9587756
Molecular FunctionGO:0019901protein kinase bindingACTBIPIUniProtKB:Q13627-2HumanPMID:24327345
Molecular FunctionGO:0019901protein kinase bindingActbIPIRGD:1306273RatPMID:12700184|RGD:2291909
Molecular FunctionGO:0098973structural constituent of postsynaptic actin cytoskeletonACTBEXPHumanPMID:18341992
Molecular FunctionGO:0098973structural constituent of postsynaptic actin cytoskeletonACTBIDAHumanPMID:18341992
Molecular FunctionGO:0098973structural constituent of postsynaptic actin cytoskeletonACTBIMPHumanPMID:18341992
Molecular FunctionGO:0030957Tat protein bindingACTBIPIUniProtKB:P04608HumanPMID:16687403
Cellular ComponentGO:0015629actin cytoskeletonACTBIDAHumanPMID:11687588
Cellular ComponentGO:0005912adherens junctionACTBIDAHumanPMID:22855531
Cellular ComponentGO:0043296apical junction complexACTBIDAHumanPMID:22855531
Cellular ComponentGO:0030424axonActbIDARatPMID:12504890|RGD:728124
Cellular ComponentGO:0072562blood microparticleACTBHDAHumanPMID:22516433
Cellular ComponentGO:0005903brush borderActbIDAMousePMID:33129760
Cellular ComponentGO:0044305calyx of HeldActbIDAMousePMID:27840001
Cellular ComponentGO:0044305calyx of HeldActbIMPMousePMID:27840001
Cellular ComponentGO:0005911cell-cell junctionACTBIMPHumanPMID:25753039
Cellular ComponentGO:0000785chromatinACTBHDAHumanPMID:16217013
Cellular ComponentGO:0030863cortical cytoskeletonActbIDAMousePMID:18723693
Cellular ComponentGO:0005737cytoplasmACTBIDAHumanPMID:24327345
Cellular ComponentGO:0005737cytoplasmActbIDAMouseMGI:MGI:6107410|PMID:24327345
Cellular ComponentGO:0005737cytoplasmActbIDAMousePMID:29042633
Cellular ComponentGO:0036464cytoplasmic ribonucleoprotein granuleACTBIDAHumanPMID:15121898
Cellular ComponentGO:0005856cytoskeletonACTBIDAHumanPMID:24327345
Cellular ComponentGO:0005856cytoskeletonActbIDAMouseMGI:MGI:6107410|PMID:24327345
Cellular ComponentGO:0005856cytoskeletonActbIDARatPMID:10683146|RGD:13601989
Cellular ComponentGO:0005829cytosolActbIDAMousePMID:11931770
Cellular ComponentGO:0005829cytosolActbIDAMousePMID:15271982
Cellular ComponentGO:0070062extracellular exosomeACTBHDAHumanPMID:11487543
Cellular ComponentGO:0070062extracellular exosomeACTBHDAHumanPMID:19199708
Cellular ComponentGO:0070062extracellular exosomeACTBHDAHumanPMID:20458337
Cellular ComponentGO:0070062extracellular exosomeACTBHDAHumanPMID:21362503
Cellular ComponentGO:0070062extracellular exosomeACTBHDAHumanPMID:23533145
Cellular ComponentGO:0005615extracellular spaceACTBHDAHumanPMID:16502470
Cellular ComponentGO:0005615extracellular spaceACTBHDAHumanPMID:22664934
Cellular ComponentGO:0005615extracellular spaceACTBHDAHumanPMID:23580065
Cellular ComponentGO:0005925focal adhesionACTBHDAHumanPMID:21423176
Cellular ComponentGO:0098978glutamatergic synapseACTBEXPHumanPMID:18341992
Cellular ComponentGO:0098978glutamatergic synapseACTBIDAHumanPMID:18341992
Cellular ComponentGO:0098978glutamatergic synapseACTBIMPHumanPMID:18341992
Cellular ComponentGO:0030027lamellipodiumACTBIDAHumanPMID:24415753
Cellular ComponentGO:0016020membraneACTBHDAHumanPMID:19946888
Cellular ComponentGO:0045121membrane raftActbIDARatPMID:14499952|RGD:12793007
Cellular ComponentGO:0043209myelin sheathActbHDAMouseMGI:MGI:3834050|PMID:17634366
Cellular ComponentGO:0035267NuA4 histone acetyltransferase complexACTBIDAHumanPMID:27153538
Cellular ComponentGO:0035267NuA4 histone acetyltransferase complexACTBIDAHumanPMID:10966108
Cellular ComponentGO:0000786nucleosomeACTBIDAHumanPMID:27153538
Cellular ComponentGO:0005634nucleusACTBIDAHumanPMID:11687588
Cellular ComponentGO:0005634nucleusActbIDAMousePMID:29042633
Cellular ComponentGO:0002102podosomeActbIDARatPMID:17111031|RGD:11541102
Cellular ComponentGO:0098871postsynaptic actin cytoskeletonACTBIDAHumanPMID:18341992
Cellular ComponentGO:0098871postsynaptic actin cytoskeletonACTBIMPHumanPMID:18341992
Cellular ComponentGO:0014069postsynaptic densityActbIDARatPMID:11226670|RGD:5147998
Cellular ComponentGO:0032991protein-containing complexACTBIDAHumanPMID:11687588
Cellular ComponentGO:0032991protein-containing complexACTBHDAHumanPMID:16217013
Cellular ComponentGO:0032991protein-containing complexACTBIDAHumanPMID:24415753
Cellular ComponentGO:0032991protein-containing complexActbIDARatPMID:15823548|RGD:1600561
Cellular ComponentGO:1990904ribonucleoprotein complexACTBIDAHumanPMID:17289661
Cellular ComponentGO:0098685Schaffer collateral - CA1 synapseActbIDAMousePMID:27840001
Cellular ComponentGO:0098685Schaffer collateral - CA1 synapseActbIMPMousePMID:27840001
Cellular ComponentGO:0001725stress fiberActbIDARatPMID:17111031|RGD:11541102
Cellular ComponentGO:0070160tight junctionACTBIDAHumanPMID:22855531
Cellular ComponentGO:0031982vesicleACTBHDAHumanPMID:19190083
Biological ProcessGO:0034333adherens junction assemblyACTBIMPHumanPMID:22855531
Biological ProcessGO:0045176apical protein localizationACTBIMPUniProtKB:Q8TEW0HumanPMID:22855531
Biological ProcessGO:0007409axonogenesisActbIDARatPMID:12504890|RGD:728124
Biological ProcessGO:0048870cell motilityACTBIMPHumanPMID:6202424
Biological ProcessGO:0072749cellular response to cytochalasin BACTBIMPHumanPMID:6202424
Biological ProcessGO:0071257cellular response to electrical stimulusActbIDARatPMID:24657527|RGD:9587756
Biological ProcessGO:0006338chromatin remodelingACTBHDAHumanPMID:16217013
Biological ProcessGO:0007623circadian rhythmActbIEPRatPMID:9483199|RGD:11552588
Biological ProcessGO:0007163establishment or maintenance of cell polarityACTBIMPHumanPMID:22855531
Biological ProcessGO:0043968histone H2A acetylationACTBIDAHumanPMID:27153538
Biological ProcessGO:0043967histone H4 acetylationACTBIDAHumanPMID:27153538
Biological ProcessGO:0001738morphogenesis of a polarized epitheliumACTBIMPHumanPMID:22855531
Biological ProcessGO:0032091negative regulation of protein bindingActbIDAMouseMGI:MGI:3829808|PMID:19118186
Biological ProcessGO:0070527platelet aggregationACTBHMPHumanPMID:23382103
Biological ProcessGO:1905168positive regulation of double-strand break repair via homologous recombinationACTBIDAHumanPMID:27153538
Biological ProcessGO:0098974postsynaptic actin cytoskeleton organizationACTBIDAHumanPMID:18341992
Biological ProcessGO:0071896protein localization to adherens junctionACTBIMPUniProtKB:P12830|UniProtKB:P35222HumanPMID:22855531
Biological ProcessGO:0051726regulation of cell cycleACTBIMPHumanPMID:27153538
Biological ProcessGO:0000079regulation of cyclin-dependent protein serine/threonine kinase activityActbIMPRatPMID:10683146|RGD:13601989
Biological ProcessGO:0051621regulation of norepinephrine uptakeACTBIGIUniProtKB:P37840HumanPMID:18331289
Biological ProcessGO:0051621regulation of norepinephrine uptakeActbIGIUniProtKB:P37840RatPMID:18331289|RGD:13601986
Biological ProcessGO:0051621regulation of norepinephrine uptakeActbIMPRatPMID:18331289|RGD:13601986
Biological ProcessGO:1903076regulation of protein localization to plasma membraneACTBIMPHumanPMID:18331289
Biological ProcessGO:1900242regulation of synaptic vesicle endocytosisActbIMPMousePMID:27840001
Biological ProcessGO:1900242regulation of synaptic vesicle endocytosisActbIDAMousePMID:27840001
Biological ProcessGO:0150111regulation of transepithelial transportACTBIMPHumanPMID:22855531
Biological ProcessGO:0022898regulation of transmembrane transporter activityACTBIGIUniProtKB:P37840HumanPMID:18331289
Biological ProcessGO:0022898regulation of transmembrane transporter activityActbIGIUniProtKB:P37840RatPMID:18331289|RGD:13601986
Biological ProcessGO:0022898regulation of transmembrane transporter activityActbIMPRatPMID:18331289|RGD:13601986
Biological ProcessGO:0035902response to immobilization stressActbIEPRatPMID:23289174|RGD:11541099
Biological ProcessGO:0009612response to mechanical stimulusActbIEPRatPMID:24780915|RGD:11541100
Biological ProcessGO:0060041retina development in camera-type eyeActbIEPRatPMID:22916200|RGD:9587758
Biological ProcessGO:0001895retina homeostasisACTBHEPHumanPMID:23580065
Biological ProcessGO:0021762substantia nigra developmentACTBHEPHumanPMID:22926577

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory