Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACTC1
  • Mouse genes Actc1
  • Rat genes Actc1
  • Zfish genes actc1a,actc1b,actc2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Actc1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	ACTC1	IDA		Human	PMID:16611632
Molecular Function	GO:0000146	microfilament motor activity	ACTC1	IDA		Human	PMID:16611632
Molecular Function	GO:0000146	microfilament motor activity	ACTC1	IDA		Human	PMID:17765196
Molecular Function	GO:0017022	myosin binding	ACTC1	IPI	UniProtKB:O62854	Human	PMID:16611632
Molecular Function	GO:0017022	myosin binding	ACTC1	IDA		Human	PMID:19799913
Molecular Function	GO:0005515	protein binding	Actc1	IPI	UniProtKB:O70468	Mouse	MGI:MGI:5466448|PMID:22982234
Molecular Function	GO:0005515	protein binding	Actc1	IPI	RGD:3710	Rat	PMID:12898519|RGD:1598723
Cellular Component	GO:0005884	actin filament	ACTC1	IDA		Human	PMID:16611632
Cellular Component	GO:0005884	actin filament	ACTC1	IDA		Human	PMID:19799913
Cellular Component	GO:0072562	blood microparticle	ACTC1	HDA		Human	PMID:22516433
Cellular Component	GO:0005737	cytoplasm	ACTC1	IDA		Human	PMID:20962418
Cellular Component	GO:0070062	extracellular exosome	ACTC1	HDA		Human	PMID:21362503
Cellular Component	GO:0070062	extracellular exosome	ACTC1	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	ACTC1	HDA		Human	PMID:22664934
Cellular Component	GO:0005615	extracellular space	ACTC1	HDA		Human	PMID:23580065
Cellular Component	GO:0005925	focal adhesion	ACTC1	HDA		Human	PMID:21423176
Cellular Component	GO:0098978	glutamatergic synapse	Actc1	IDA		Mouse	PMID:24413018
Cellular Component	GO:0098978	glutamatergic synapse	Actc1	EXP		Mouse	PMID:24413018
Cellular Component	GO:0031674	I band	Actc1	IDA		Mouse	PMID:16481394
Cellular Component	GO:0016020	membrane	ACTC1	HDA		Human	PMID:19946888
Cellular Component	GO:0030017	sarcomere	ACTC1	IDA		Human	PMID:16288873
Cellular Component	GO:0045202	synapse	Actc1	EXP		Mouse	PMID:24413018
Cellular Component	GO:0045202	synapse	Actc1	IDA		Mouse	PMID:24413018
Biological Process	GO:0030048	actin filament-based movement	ACTC1	IDA		Human	PMID:16611632
Biological Process	GO:0070252	actin-mediated cell contraction	Actc1	IMP		Mouse	PMID:22750946
Biological Process	GO:0033275	actin-myosin filament sliding	ACTC1	IMP		Human	PMID:19799913
Biological Process	GO:0031032	actomyosin structure organization	Actc1	IMP	MGI:MGI:2180072	Mouse	PMID:14605248
Biological Process	GO:0036302	atrioventricular canal development	actc1a	IMP	ZFIN:ZDB-MRPHLNO-121012-1	Zfish	PMID:22751927
Biological Process	GO:0036302	atrioventricular canal development	actc1a	IMP	ZFIN:ZDB-GENO-120928-1	Zfish	PMID:22751927
Biological Process	GO:0060048	cardiac muscle contraction	Actc1	IDA		Rat	PMID:14551059|RGD:1600569
Biological Process	GO:0055008	cardiac muscle tissue morphogenesis	Actc1	IMP	MGI:MGI:2180072	Mouse	PMID:14605248
Biological Process	GO:0055003	cardiac myofibril assembly	Actc1	IMP	MGI:MGI:2180072	Mouse	PMID:9114002
Biological Process	GO:0003272	endocardial cushion formation	actc1a	IMP	ZFIN:ZDB-MRPHLNO-121012-1	Zfish	PMID:22751927
Biological Process	GO:0003272	endocardial cushion formation	actc1a	IMP	ZFIN:ZDB-GENO-120928-1	Zfish	PMID:22751927
Biological Process	GO:0003203	endocardial cushion morphogenesis	actc1a	IMP	ZFIN:ZDB-GENO-120928-1	Zfish	PMID:22751927
Biological Process	GO:0060047	heart contraction	ACTC1	IMP		Human	PMID:17611253
Biological Process	GO:0060047	heart contraction	ACTC1	IMP		Human	PMID:17947298
Biological Process	GO:0060047	heart contraction	ACTC1	IMP		Human	PMID:9563954
Biological Process	GO:0043066	negative regulation of apoptotic process	Actc1	IMP	MGI:MGI:2180072	Mouse	PMID:14605248
Biological Process	GO:0045471	response to ethanol	Actc1	IEP		Rat	PMID:15690316|RGD:1598722
Biological Process	GO:0009410	response to xenobiotic stimulus	Actc1	IEP		Rat	PMID:16343576|RGD:1598724
Biological Process	GO:0030240	skeletal muscle thin filament assembly	Actc1	IMP	MGI:MGI:2180072	Mouse	PMID:9114002

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern