Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACTG1
  • Mouse genes Actg1
  • Rat genes Actg1,LOC100361457
  • Zfish genes actb1,actb2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Actg1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	ACTG1	IPI	UniProtKB:P63261	Human	PMID:16189514
Molecular Function	GO:0042802	identical protein binding	ACTG1	IPI	UniProtKB:P63261	Human	PMID:21516116
Molecular Function	GO:0042802	identical protein binding	ACTG1	IPI	UniProtKB:P63261	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	ACTG1	IPI	UniProtKB:P63261	Human	PMID:25910212
Molecular Function	GO:0005522	profilin binding	ACTG1	IDA		Human	PMID:28493397
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:P23528	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:P60709	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:P60981	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:Q9Y281	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:P40692	Human	PMID:20706999
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:P60709	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:O60826	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:P23528	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:P40123	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:P60709	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:P60981	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:Q08426	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:Q1KLZ0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:Q549N0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:Q96HA8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:P40123	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:P60709	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:Q9Y281	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:P42858	Human	PMID:25959826
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:P47756	Human	PMID:28493397
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:Q12792	Human	PMID:28493397
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:P60709	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:P60709	Human	PMID:30886144
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:P60709	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:Q08426	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:Q96HA8	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:P23528	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:P40123	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:P60709	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:P60981	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:Q16543	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:Q96HA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:Q9Y281	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTG1	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Actg1	IPI	UniProtKB:Q08460	Mouse	MGI:MGI:3852248|PMID:19423573
Molecular Function	GO:0005200	structural constituent of cytoskeleton	Actg1	IDA		Mouse	PMID:15194427
Molecular Function	GO:0098973	structural constituent of postsynaptic actin cytoskeleton	Actg1	IDA		Rat	PMID:9875357|RGD:13702432
Molecular Function	GO:0098973	structural constituent of postsynaptic actin cytoskeleton	LOC100361457	IDA		Rat	PMID:9875357|RGD:13702432
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ACTG1	IPI	UniProtKB:O60260	Human	PMID:21753002
Cellular Component	GO:0015629	actin cytoskeleton	Actg1	IDA		Mouse	PMID:29891944
Cellular Component	GO:0015629	actin cytoskeleton	Actg1	IDA		Mouse	PMID:15194427
Cellular Component	GO:0005884	actin filament	ACTG1	IDA		Human	PMID:28493397
Cellular Component	GO:0043296	apical junction complex	ACTG1	IDA		Human	PMID:22855531
Cellular Component	GO:0045177	apical part of cell	Actg1	IDA		Mouse	PMID:29891944
Cellular Component	GO:0120220	basal body patch	Actg1	IDA		Mouse	PMID:29891944
Cellular Component	GO:0072562	blood microparticle	ACTG1	HDA		Human	PMID:22516433
Cellular Component	GO:0044305	calyx of Held	Actg1	IDA		Mouse	PMID:27840001
Cellular Component	GO:0044305	calyx of Held	Actg1	IMP		Mouse	PMID:27840001
Cellular Component	GO:0005911	cell-cell junction	ACTG1	IDA		Human	PMID:22855531
Cellular Component	GO:0070062	extracellular exosome	ACTG1	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	ACTG1	IDA		Human	PMID:21557262
Cellular Component	GO:0070062	extracellular exosome	ACTG1	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	ACTG1	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	ACTG1	HDA		Human	PMID:23580065
Cellular Component	GO:0031941	filamentous actin	Actg1	IDA		Mouse	PMID:18796539
Cellular Component	GO:0016020	membrane	ACTG1	HDA		Human	PMID:19946888
Cellular Component	GO:0043209	myelin sheath	Actg1	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0030016	myofibril	Actg1	IDA		Mouse	PMID:15194427
Cellular Component	GO:0005634	nucleus	ACTG1	HDA		Human	PMID:21630459
Cellular Component	GO:0045335	phagocytic vesicle	Actg1	IDA		Mouse	PMID:19144319
Cellular Component	GO:0098871	postsynaptic actin cytoskeleton	Actg1	IDA		Rat	PMID:9875357|RGD:13702432
Cellular Component	GO:0098871	postsynaptic actin cytoskeleton	LOC100361457	IDA		Rat	PMID:9875357|RGD:13702432
Cellular Component	GO:0099143	presynaptic actin cytoskeleton	Actg1	IDA		Rat	PMID:9875357|RGD:13702432
Cellular Component	GO:0099143	presynaptic actin cytoskeleton	LOC100361457	IDA		Rat	PMID:9875357|RGD:13702432
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Actg1	IDA		Mouse	PMID:27840001
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Actg1	IMP		Mouse	PMID:27840001
Biological Process	GO:0001525	angiogenesis	ACTG1	IMP		Human	PMID:25705373
Biological Process	GO:0071346	cellular response to type II interferon	Actg1	IDA		Mouse	PMID:19144319
Biological Process	GO:0001738	morphogenesis of a polarized epithelium	ACTG1	IMP		Human	PMID:22855531
Biological Process	GO:0070527	platelet aggregation	ACTG1	HMP		Human	PMID:23382103
Biological Process	GO:0030335	positive regulation of cell migration	ACTG1	IMP		Human	PMID:25705373
Biological Process	GO:0010628	positive regulation of gene expression	ACTG1	IMP	UniProtKB:P33151	Human	PMID:25705373
Biological Process	GO:0090303	positive regulation of wound healing	ACTG1	IMP		Human	PMID:25705373
Biological Process	GO:1902396	protein localization to bicellular tight junction	ACTG1	IMP	UniProtKB:O95832|UniProtKB:Q07157|UniProtKB:Q16625	Human	PMID:22855531
Biological Process	GO:0051893	regulation of focal adhesion assembly	ACTG1	IMP		Human	PMID:25705373
Biological Process	GO:0051492	regulation of stress fiber assembly	ACTG1	IMP		Human	PMID:25705373
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	Actg1	IDA		Mouse	PMID:27840001
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	Actg1	IMP		Mouse	PMID:27840001
Biological Process	GO:0150111	regulation of transepithelial transport	ACTG1	IMP		Human	PMID:22855531
Biological Process	GO:0051592	response to calcium ion	Actg1	IEP		Rat	PMID:8476030|RGD:1598730
Biological Process	GO:0009612	response to mechanical stimulus	Actg1	IEP		Rat	PMID:24780915|RGD:11541100
Biological Process	GO:0001895	retina homeostasis	ACTG1	HEP		Human	PMID:23580065
Biological Process	GO:0045214	sarcomere organization	Actg1	IDA		Mouse	PMID:15194427
Biological Process	GO:0120192	tight junction assembly	ACTG1	IMP		Human	PMID:22855531

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern