Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACTN1
  • Mouse genes Actn1
  • Rat genes Actn1
  • Zfish genes actn1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Actn1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	ACTN1	IDA		Human	PMID:11223950
Molecular Function	GO:0051015	actin filament binding	Actn1	IDA		Mouse	MGI:MGI:5640954|PMID:11223950
Molecular Function	GO:0051015	actin filament binding	Actn1	IDA		Mouse	PMID:15465019
Molecular Function	GO:0005519	cytoskeletal regulatory protein binding	Actn1	IPI	UniProtKB:Q66HL2	Rat	PMID:21210813|RGD:10047315
Molecular Function	GO:0003725	double-stranded RNA binding	ACTN1	IDA		Human	PMID:21266579
Molecular Function	GO:0005178	integrin binding	ACTN1	IPI	UniProtKB:P09055	Human	PMID:11223950
Molecular Function	GO:0005178	integrin binding	ACTN1	IDA		Human	PMID:7983147
Molecular Function	GO:0005178	integrin binding	Actn1	IPI	UniProtKB:P09055	Mouse	MGI:MGI:5640954|PMID:11223950
Molecular Function	GO:0030374	nuclear receptor coactivator activity	ACTN1	IDA		Human	PMID:22351778
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:O00151	Human	PMID:10753915
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:P15311	Human	PMID:10793131
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q9Y696	Human	PMID:10793131
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q8WZ42	Human	PMID:11101506
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:O00151	Human	PMID:11110697
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q8VC66	Human	PMID:12446711
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:P27958:PRO_0000037577	Human	PMID:14623081
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q9NP98	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:P12931	Human	PMID:16291744
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q96QZ7	Human	PMID:16464232
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q9Y223	Human	PMID:18560563
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:P50479	Human	PMID:20120020
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q13936	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q96QS3	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q9BYB0	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:B2R8Y4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:P00973	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q7L775	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q8IY33	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q8NA61	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q8NC69	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q9NPC6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:P00973-2	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:P35609	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q9NPC6	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q8N3V7	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:A0A0S2Z4Y0	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q8N3V7	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:P00973	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:O75604	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:O95257	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:P05198	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:P10599	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:P50479	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:P63172	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q08043	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q6ZUT1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q7L775	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q8IY33	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q8TBB1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q92624	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q9H987-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q9NP98	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q9NPC6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN1	IPI	UniProtKB:Q9NWQ9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Actn1	IPI	UniProtKB:Q15078	Mouse	MGI:MGI:3687901|PMID:12223541
Molecular Function	GO:0005515	protein binding	Actn1	IPI	UniProtKB:Q768S5	Mouse	MGI:MGI:3689791|PMID:16043482
Molecular Function	GO:0005515	protein binding	Actn1	IPI	UniProtKB:Q3TN34	Mouse	MGI:MGI:5514064|PMID:23890175
Molecular Function	GO:0005515	protein binding	Actn1	IPI	PR:Q8K4E0	Mouse	PMID:22693585
Molecular Function	GO:0005515	protein binding	Actn1	IPI	UniProtKB:P36202	Rat	PMID:14729062|RGD:1300470
Molecular Function	GO:0005515	protein binding	Actn1	IPI	RGD:1359203	Rat	PMID:15505042|RGD:1359754
Molecular Function	GO:0005515	protein binding	Actn1	IPI	RGD:1559992	Rat	PMID:15843396|RGD:7175289
Molecular Function	GO:0005515	protein binding	Actn1	IPI	UniProtKB:P50617	Rat	PMID:16464232|RGD:21201256
Molecular Function	GO:0005515	protein binding	Actn1	IPI	UniProtKB:P39052	Rat	PMID:21210813|RGD:10047315
Molecular Function	GO:0005515	protein binding	Actn1	IPI	UniProtKB:P52944	Rat	PMID:22659164|RGD:13432282
Molecular Function	GO:0019904	protein domain specific binding	Actn1	IPI	RGD:1302984	Rat	PMID:15140894|RGD:1303994
Molecular Function	GO:0042803	protein homodimerization activity	ACTN1	IDA		Human	PMID:11223950
Molecular Function	GO:0042803	protein homodimerization activity	Actn1	IDA		Mouse	MGI:MGI:5640954|PMID:11223950
Molecular Function	GO:0099186	structural constituent of postsynapse	ACTN1	IDA		Human	PMID:29429936
Molecular Function	GO:0099186	structural constituent of postsynapse	ACTN1	IMP		Human	PMID:29429936
Molecular Function	GO:0044325	transmembrane transporter binding	ACTN1	IPI	UniProtKB:Q9P0L9	Human	PMID:17944866
Molecular Function	GO:0044325	transmembrane transporter binding	ACTN1	IPI	UniProtKB:Q14524	Human	PMID:19943616
Molecular Function	GO:0017166	vinculin binding	ACTN1	IDA		Human	PMID:11223950
Molecular Function	GO:0017166	vinculin binding	ACTN1	IPI	UniProtKB:P18206	Human	PMID:15988023
Molecular Function	GO:0017166	vinculin binding	Actn1	IDA		Mouse	MGI:MGI:5640954|PMID:11223950
Cellular Component	GO:0005884	actin filament	ACTN1	IDA		Human	PMID:23434115
Cellular Component	GO:0005884	actin filament	ACTN1	IDA		Human	PMID:24069336
Cellular Component	GO:0005903	brush border	Actn1	IDA		Mouse	MGI:MGI:5621262|PMID:22114352
Cellular Component	GO:0030054	cell junction	Actn1	IDA		Rat	PMID:21210813|RGD:10047315
Cellular Component	GO:0042995	cell projection	ACTN1	IDA		Human	PMID:16464232
Cellular Component	GO:0005911	cell-cell junction	ACTN1	IDA		Human	PMID:11223950
Cellular Component	GO:0030864	cortical actin cytoskeleton	Actn1	IDA		Rat	PMID:15505042|RGD:1359754
Cellular Component	GO:0005737	cytoplasm	ACTN1	IDA		Human	PMID:16464232
Cellular Component	GO:0005737	cytoplasm	ACTN1	IDA		Human	PMID:23434115
Cellular Component	GO:0005737	cytoplasm	Actn1	IDA		Rat	PMID:12223541|RGD:8554161
Cellular Component	GO:0005856	cytoskeleton	Actn1	IDA		Rat	PMID:21210813|RGD:10047315
Cellular Component	GO:0043197	dendritic spine	Actn1	IDA		Rat	PMID:12223541|RGD:8554161
Cellular Component	GO:0070062	extracellular exosome	ACTN1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	ACTN1	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	ACTN1	HDA		Human	PMID:21362503
Cellular Component	GO:0070062	extracellular exosome	ACTN1	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	ACTN1	HDA		Human	PMID:16502470
Cellular Component	GO:0005916	fascia adherens	Actn1	IDA		Mouse	PMID:11732910
Cellular Component	GO:0005925	focal adhesion	ACTN1	IDA		Human	PMID:11223950
Cellular Component	GO:0005925	focal adhesion	ACTN1	IMP		Human	PMID:16807302
Cellular Component	GO:0005925	focal adhesion	ACTN1	HDA		Human	PMID:21423176
Cellular Component	GO:0098978	glutamatergic synapse	ACTN1	IDA		Human	PMID:29429936
Cellular Component	GO:0098978	glutamatergic synapse	ACTN1	IMP		Human	PMID:29429936
Cellular Component	GO:0005634	nucleus	Actn1	IDA		Rat	PMID:19094982|RGD:2304013
Cellular Component	GO:0005886	plasma membrane	Actn1	IDA		Rat	PMID:21210813|RGD:10047315
Cellular Component	GO:0001726	ruffle	ACTN1	IDA		Human	PMID:11223950
Cellular Component	GO:0001726	ruffle	Actn1	IDA		Mouse	MGI:MGI:3703181|PMID:17298598
Cellular Component	GO:0030017	sarcomere	Actn1	IDA		Mouse	PMID:24364879
Cellular Component	GO:0001725	stress fiber	ACTN1	IDA		Human	PMID:11223950
Cellular Component	GO:0001725	stress fiber	Actn1	IDA		Mouse	MGI:MGI:5514064|PMID:23890175
Cellular Component	GO:0001725	stress fiber	Actn1	IDA		Rat	PMID:15505042|RGD:1359754
Cellular Component	GO:0030018	Z disc	ACTN1	IDA		Human	PMID:7750553
Cellular Component	GO:0030018	Z disc	Actn1	IDA		Mouse	PMID:15665106
Cellular Component	GO:0030018	Z disc	Actn1	IDA		Mouse	PMID:20368620
Cellular Component	GO:0030018	Z disc	Actn1	IDA		Mouse	PMID:20215401
Cellular Component	GO:0030018	Z disc	Actn1	IDA		Mouse	PMID:18332105
Biological Process	GO:0051017	actin filament bundle assembly	Actn1	IDA		Mouse	MGI:MGI:3689791|PMID:16043482
Biological Process	GO:0051639	actin filament network formation	ACTN1	IMP		Human	PMID:24069336
Biological Process	GO:0007015	actin filament organization	ACTN1	IMP		Human	PMID:23434115
Biological Process	GO:0048041	focal adhesion assembly	ACTN1	IMP		Human	PMID:16807302
Biological Process	GO:0030220	platelet formation	ACTN1	IMP		Human	PMID:23434115
Biological Process	GO:0036344	platelet morphogenesis	ACTN1	IMP		Human	PMID:23434115
Biological Process	GO:0036344	platelet morphogenesis	ACTN1	IMP		Human	PMID:24069336

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern