Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACTN3
  • Mouse genes Actn3
  • Rat genes Actn3
  • Zfish genes actn3a,actn3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Actn3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	Actn3	IDA		Mouse	PMID:15465019
Molecular Function	GO:0042802	identical protein binding	ACTN3	IPI	UniProtKB:Q08043	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q9NP98	Human	PMID:11171996
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q86TC9	Human	PMID:11309420
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:A2RRN7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:A8MYP8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:O14561	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:O14964	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:O43707	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:O75031	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:O75604	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:O95863	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:O95865	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:P05166	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:P12814	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:P26440	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:P35452-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:P42830	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:P43360	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:P48668	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:P78358	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:P78424	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q13077	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q13882	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q14134	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q14D33	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q16610	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q53TS8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q5JUK2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q6NYC8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q6P1L6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q6ZUT1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q86YD7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q8IY33	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q8TBB1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q96DX5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q99959-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q9BUY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q9BZE0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q9GZU7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q9H1P6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q9H987-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q9NP98	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q9UBF9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q9UBR4-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN3	IPI	UniProtKB:Q9Y6H3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Actn3	IPI	PR:Q9JJW5	Mouse	PMID:11114196
Molecular Function	GO:0005515	protein binding	Actn3	IPI	PR:Q8K4E0	Mouse	PMID:22693585
Molecular Function	GO:0044325	transmembrane transporter binding	ACTN3	IPI	UniProtKB:Q14524	Human	PMID:19943616
Cellular Component	GO:0005903	brush border	Actn3	IDA		Mouse	MGI:MGI:5621262|PMID:22114352
Cellular Component	GO:0070062	extracellular exosome	ACTN3	HDA		Human	PMID:23533145
Cellular Component	GO:0005925	focal adhesion	ACTN3	IMP		Human	PMID:16807302
Cellular Component	GO:0030017	sarcomere	Actn3	IDA		Mouse	PMID:16585392
Cellular Component	GO:0030017	sarcomere	Actn3	IDA		Mouse	PMID:24840128
Cellular Component	GO:0030018	Z disc	Actn3	IDA		Mouse	PMID:20368620
Cellular Component	GO:0030018	Z disc	Actn3	IDA		Mouse	PMID:20215401
Biological Process	GO:0060349	bone morphogenesis	Actn3	IMP		Mouse	MGI:MGI:5291888|PMID:21784188
Biological Process	GO:0048041	focal adhesion assembly	ACTN3	IMP		Human	PMID:16807302
Biological Process	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	Actn3	IMP		Mouse	MGI:MGI:5554485|PMID:24234654
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	Actn3	IMP		Mouse	MGI:MGI:5645625|PMID:25590636
Biological Process	GO:0045820	negative regulation of glycolytic process	Actn3	IMP		Mouse	MGI:MGI:3759354|PMID:17828264
Biological Process	GO:0090324	negative regulation of oxidative phosphorylation	Actn3	IMP		Mouse	MGI:MGI:3778600|PMID:18178581
Biological Process	GO:0090324	negative regulation of oxidative phosphorylation	Actn3	IMP		Mouse	MGI:MGI:5554485|PMID:24234654
Biological Process	GO:1901078	negative regulation of relaxation of muscle	Actn3	IMP		Mouse	MGI:MGI:3778600|PMID:18178581
Biological Process	GO:1900159	positive regulation of bone mineralization involved in bone maturation	Actn3	IMP		Mouse	MGI:MGI:5291888|PMID:21784188
Biological Process	GO:0031448	positive regulation of fast-twitch skeletal muscle fiber contraction	Actn3	IMP		Mouse	MGI:MGI:3778600|PMID:18178581
Biological Process	GO:1904025	positive regulation of glucose catabolic process to lactate via pyruvate	Actn3	IMP		Mouse	MGI:MGI:3759354|PMID:17828264
Biological Process	GO:0048743	positive regulation of skeletal muscle fiber development	Actn3	IMP		Mouse	MGI:MGI:3778600|PMID:18178581
Biological Process	GO:0048633	positive regulation of skeletal muscle tissue growth	Actn3	IMP		Mouse	MGI:MGI:5554485|PMID:24234654
Biological Process	GO:0048633	positive regulation of skeletal muscle tissue growth	Actn3	IMP		Mouse	MGI:MGI:3778600|PMID:18178581
Biological Process	GO:1903715	regulation of aerobic respiration	Actn3	IMP		Mouse	MGI:MGI:3759354|PMID:17828264
Biological Process	GO:0090257	regulation of muscle system process	Actn3	IMP		Mouse	MGI:MGI:3778600|PMID:18178581
Biological Process	GO:0014728	regulation of the force of skeletal muscle contraction	Actn3	IMP		Mouse	MGI:MGI:3759354|PMID:17828264
Biological Process	GO:0014894	response to denervation involved in regulation of muscle adaptation	Actn3	IMP		Mouse	MGI:MGI:5554485|PMID:24234654
Biological Process	GO:0014732	skeletal muscle atrophy	Actn3	IMP		Mouse	MGI:MGI:5554485|PMID:24234654
Biological Process	GO:0014883	transition between fast and slow fiber	Actn3	IMP		Mouse	MGI:MGI:3759354|PMID:17828264

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern