Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACTR2
  • Mouse genes Actr2
  • Rat genes Actr2
  • Zfish genes actr2a,actr2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Actr2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	ACTR2	IDA		Human	PMID:11741539
Molecular Function	GO:0008092	cytoskeletal protein binding	Actr2	IDA		Rat	PMID:18725535|RGD:11530065
Molecular Function	GO:0005515	protein binding	ACTR2	IPI	UniProtKB:O75366,UniProtKB:P61158	Human	PMID:29058690
Molecular Function	GO:0005515	protein binding	ACTR2	IPI	UniProtKB:Q8IWG1	Human	PMID:32128961
Molecular Function	GO:0005515	protein binding	Actr2	IPI	PR:Q9JLI7	Mouse	PMID:31146259
Molecular Function	GO:0005515	protein binding	Actr2	IPI	RGD:2405	Rat	PMID:17615370|RGD:8693596
Molecular Function	GO:0005200	structural constituent of cytoskeleton	ACTR2	IDA		Human	PMID:11741539
Cellular Component	GO:0030478	actin cap	Actr2	IDA		Mouse	PMID:21874009
Cellular Component	GO:0030478	actin cap	Actr2	IDA		Mouse	PMID:21494665
Cellular Component	GO:0005885	Arp2/3 protein complex	ACTR2	IDA		Human	PMID:11741539
Cellular Component	GO:0005885	Arp2/3 protein complex	ACTR2	IDA		Human	PMID:17220302
Cellular Component	GO:0005938	cell cortex	Actr2	IDA		Mouse	PMID:21494665
Cellular Component	GO:0005737	cytoplasm	ACTR2	IDA		Human	PMID:17220302
Cellular Component	GO:0005737	cytoplasm	ACTR2	IDA		Human	PMID:22684256
Cellular Component	GO:0070062	extracellular exosome	ACTR2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	ACTR2	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	ACTR2	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	ACTR2	HDA		Human	PMID:23533145
Cellular Component	GO:0005925	focal adhesion	ACTR2	HDA		Human	PMID:21423176
Cellular Component	GO:0030027	lamellipodium	Actr2	IDA		Rat	PMID:17442843|RGD:11567221
Cellular Component	GO:0016020	membrane	ACTR2	HDA		Human	PMID:19946888
Cellular Component	GO:0005634	nucleus	ACTR2	IDA		Human	PMID:17220302
Cellular Component	GO:0005634	nucleus	ACTR2	IDA		Human	PMID:29925947
Cellular Component	GO:0061825	podosome core	Actr2	IDA		Rat	PMID:23158496|RGD:11530035
Cellular Component	GO:0098794	postsynapse	Actr2	EXP		Rat	PMID:15020595|RGD:13702264
Cellular Component	GO:0098794	postsynapse	Actr2	IDA		Rat	PMID:15020595|RGD:13702264
Cellular Component	GO:0014069	postsynaptic density	Actr2	IDA		Rat	PMID:27720500|RGD:11567211
Cellular Component	GO:0035861	site of double-strand break	ACTR2	IDA		Human	PMID:29925947
Biological Process	GO:0030036	actin cytoskeleton organization	Actr2	IMP		Mouse	PMID:21874009
Biological Process	GO:0034314	Arp2/3 complex-mediated actin nucleation	ACTR2	IDA		Human	PMID:11741539
Biological Process	GO:0034314	Arp2/3 complex-mediated actin nucleation	ACTR2	IDA		Human	PMID:17220302
Biological Process	GO:0034314	Arp2/3 complex-mediated actin nucleation	ACTR2	IDA		Human	PMID:29925947
Biological Process	GO:0008306	associative learning	Actr2	IEP		Rat	PMID:27720500|RGD:11567211
Biological Process	GO:0008356	asymmetric cell division	Actr2	IGI	MGI:MGI:1921367	Mouse	PMID:21494665
Biological Process	GO:0035984	cellular response to trichostatin A	Actr2	IEP		Rat	PMID:12445420|RGD:632492
Biological Process	GO:0071346	cellular response to type II interferon	Actr2	IGI	MGI:MGI:1921367	Mouse	PMID:19144319
Biological Process	GO:0060271	cilium assembly	ACTR2	IMP		Human	PMID:22684256
Biological Process	GO:0016482	cytosolic transport	Actr2	IMP		Mouse	PMID:21874009
Biological Process	GO:0007163	establishment or maintenance of cell polarity	Actr2	IGI	MGI:MGI:1921367	Mouse	PMID:21494665
Biological Process	GO:0051321	meiotic cell cycle	Actr2	IGI	MGI:MGI:1921367	Mouse	PMID:21494665
Biological Process	GO:0016344	meiotic chromosome movement towards spindle pole	Actr2	IGI	MGI:MGI:1921367	Mouse	PMID:23439682
Biological Process	GO:0033206	meiotic cytokinesis	Actr2	IGI	MGI:MGI:1921367	Mouse	PMID:21494665
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	Actr2	IMP		Rat	PMID:23441206|RGD:11530033
Biological Process	GO:1905168	positive regulation of double-strand break repair via homologous recombination	ACTR2	IDA		Human	PMID:29925947
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	ACTR2	IDA		Human	PMID:29058690
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ACTR2	IDA		Human	PMID:17220302
Biological Process	GO:0060319	primitive erythrocyte differentiation	actr2b	IMP		Zfish	PMID:24240475
Biological Process	GO:0045471	response to ethanol	Actr2	IEP		Rat	PMID:26185205|RGD:11530039
Biological Process	GO:0035902	response to immobilization stress	Actr2	IEP		Rat	PMID:22882295|RGD:11530036
Biological Process	GO:0051653	spindle localization	Actr2	IGI	MGI:MGI:1921367	Mouse	PMID:21494665

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern