Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACTR3
  • Mouse genes Actr3
  • Rat genes Actr3
  • Zfish genes actr3,actr3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Actr3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	Actr3	IDA		Rat	PMID:20566646|RGD:11530051
Molecular Function	GO:0051015	actin filament binding	ACTR3	IDA		Human	PMID:11741539
Molecular Function	GO:0051117	ATPase binding	Actr3	IPI	RGD:631345	Rat	PMID:23403943|RGD:11530034
Molecular Function	GO:0005515	protein binding	ACTR3	IPI	UniProtKB:P17535	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	ACTR3	IPI	UniProtKB:O75366,UniProtKB:P61160	Human	PMID:29058690
Molecular Function	GO:0005515	protein binding	ACTR3	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ACTR3	IPI	UniProtKB:P10809	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ACTR3	IPI	UniProtKB:P13051-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ACTR3	IPI	UniProtKB:Q00535	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ACTR3	IPI	UniProtKB:Q96BI3-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ACTR3	IPI	UniProtKB:Q9H3R5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ACTR3	IPI	UniProtKB:Q9ULD4-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ACTR3	IPI	UniProtKB:Q9UNE7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Actr3	IPI	UniProtKB:Q60598	Mouse	MGI:MGI:1931605|PMID:11231575
Molecular Function	GO:0005515	protein binding	Actr3	IPI	UniProtKB:Q60598	Mouse	MGI:MGI:5437443|PMID:11018051
Molecular Function	GO:0005515	protein binding	Actr3	IPI	PR:Q8BH64	Mouse	PMID:15247266
Molecular Function	GO:0005515	protein binding	Actr3	IPI	PR:Q91YD9	Mouse	PMID:15247266
Molecular Function	GO:0005515	protein binding	Actr3	IPI	RGD:1347655	Rat	PMID:18064521|RGD:2292230
Molecular Function	GO:0005515	protein binding	Actr3	IPI	RGD:70885	Rat	PMID:22319661|RGD:11530045
Molecular Function	GO:0005515	protein binding	Actr3	IPI	RGD:735144	Rat	PMID:22797892|RGD:11530040
Molecular Function	GO:0005515	protein binding	Actr3	IPI	RGD:2322545	Rat	PMID:23546604|RGD:11530027
Molecular Function	GO:0005200	structural constituent of cytoskeleton	ACTR3	IDA		Human	PMID:11741539
Cellular Component	GO:0005884	actin filament	Actr3	IDA		Rat	PMID:10209028|RGD:2306208
Cellular Component	GO:0061831	apical ectoplasmic specialization	Actr3	IDA		Rat	PMID:23546604|RGD:11530027
Cellular Component	GO:0061828	apical tubulobulbar complex	Actr3	IDA		Rat	PMID:22797892|RGD:11530040
Cellular Component	GO:0005885	Arp2/3 protein complex	ACTR3	IDA		Human	PMID:11741539
Cellular Component	GO:0005885	Arp2/3 protein complex	ACTR3	IDA		Human	PMID:17220302
Cellular Component	GO:0061832	basal ectoplasmic specialization	Actr3	IDA		Rat	PMID:23546604|RGD:11530027
Cellular Component	GO:0005903	brush border	Actr3	IDA		Mouse	MGI:MGI:5621262|PMID:22114352
Cellular Component	GO:0031252	cell leading edge	Actr3	IDA		Rat	PMID:17855387|RGD:2306203
Cellular Component	GO:0005911	cell-cell junction	Actr3	IDA		Mouse	PMID:23793062
Cellular Component	GO:0005911	cell-cell junction	Actr3	IDA		Rat	PMID:22319661|RGD:11530045
Cellular Component	GO:0061830	concave side of sperm head	Actr3	IDA		Rat	PMID:22332112|RGD:12791268
Cellular Component	GO:0005737	cytoplasm	ACTR3	IDA		Human	PMID:17220302
Cellular Component	GO:0005737	cytoplasm	Actr3	IDA		Rat	PMID:15252126|RGD:2306210
Cellular Component	GO:0060076	excitatory synapse	Actr3	IDA		Rat	PMID:18430734|RGD:2306201
Cellular Component	GO:0070062	extracellular exosome	ACTR3	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	ACTR3	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	ACTR3	HDA		Human	PMID:23533145
Cellular Component	GO:0005925	focal adhesion	ACTR3	HDA		Human	PMID:21423176
Cellular Component	GO:0098978	glutamatergic synapse	Actr3	IDA		Rat	PMID:18430734|RGD:2306201
Cellular Component	GO:0098978	glutamatergic synapse	Actr3	IMP		Rat	PMID:18430734|RGD:2306201
Cellular Component	GO:0000139	Golgi membrane	Actr3	IDA		Rat	PMID:15147909|RGD:2306211
Cellular Component	GO:0030056	hemidesmosome	Actr3	IDA		Rat	PMID:15093736|RGD:2306209
Cellular Component	GO:0030027	lamellipodium	ACTR3	IDA		Human	PMID:9230079
Cellular Component	GO:0030027	lamellipodium	Actr3	IDA		Mouse	PMID:14657280
Cellular Component	GO:0030027	lamellipodium	Actr3	IDA		Rat	PMID:15252126|RGD:2306210
Cellular Component	GO:0061851	leading edge of lamellipodium	Actr3	IDA		Rat	PMID:17855387|RGD:2306203
Cellular Component	GO:0016020	membrane	ACTR3	HDA		Human	PMID:19946888
Cellular Component	GO:0005634	nucleus	ACTR3	IDA		Human	PMID:16767080
Cellular Component	GO:0005634	nucleus	ACTR3	IDA		Human	PMID:17220302
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Actr3	IDA		Rat	PMID:22319661|RGD:11530045
Cellular Component	GO:0002102	podosome	Actr3	IDA		Rat	PMID:15093736|RGD:2306209
Cellular Component	GO:0002102	podosome	Actr3	IDA		Rat	PMID:17224451|RGD:2306207
Cellular Component	GO:0061825	podosome core	Actr3	IDA		Rat	PMID:24290759|RGD:11530018
Cellular Component	GO:0098794	postsynapse	Actr3	EXP		Rat	PMID:15020595|RGD:13702264
Cellular Component	GO:0098794	postsynapse	Actr3	IDA		Rat	PMID:15020595|RGD:13702264
Cellular Component	GO:0098794	postsynapse	Actr3	IDA		Rat	PMID:18430734|RGD:2306201
Cellular Component	GO:0098794	postsynapse	Actr3	IMP		Rat	PMID:18430734|RGD:2306201
Cellular Component	GO:0001726	ruffle	Actr3	IDA		Rat	PMID:10209028|RGD:2306208
Biological Process	GO:0034314	Arp2/3 complex-mediated actin nucleation	ACTR3	IDA		Human	PMID:11741539
Biological Process	GO:0034314	Arp2/3 complex-mediated actin nucleation	ACTR3	IDA		Human	PMID:17220302
Biological Process	GO:0048708	astrocyte differentiation	Actr3	IMP		Rat	PMID:23843614|RGD:8553949
Biological Process	GO:0008356	asymmetric cell division	Actr3	IGI	MGI:MGI:1913963	Mouse	PMID:21494665
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	Actr3	IEP		Rat	PMID:10209028|RGD:2306208
Biological Process	GO:0071347	cellular response to interleukin-1	Actr3	IEP		Rat	PMID:21191089|RGD:11571626
Biological Process	GO:1905835	cellular response to pyrimidine ribonucleotide	Actr3	IEP		Rat	PMID:22065602|RGD:11571625
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Actr3	IDA		Rat	PMID:22319661|RGD:11530045
Biological Process	GO:0035984	cellular response to trichostatin A	Actr3	IEP		Rat	PMID:12445420|RGD:632492
Biological Process	GO:1905837	cellular response to triterpenoid	Actr3	IEP		Rat	PMID:20566646|RGD:11530051
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Actr3	IDA		Rat	PMID:22319661|RGD:11530045
Biological Process	GO:0071346	cellular response to type II interferon	Actr3	IGI	MGI:MGI:1913963	Mouse	PMID:19144319
Biological Process	GO:0060271	cilium assembly	ACTR3	IMP		Human	PMID:20393563
Biological Process	GO:0007163	establishment or maintenance of cell polarity	Actr3	IGI	MGI:MGI:1913963	Mouse	PMID:21494665
Biological Process	GO:0051321	meiotic cell cycle	Actr3	IGI	MGI:MGI:1913963	Mouse	PMID:21494665
Biological Process	GO:0016344	meiotic chromosome movement towards spindle pole	Actr3	IGI	MGI:MGI:1913963	Mouse	PMID:23439682
Biological Process	GO:0033206	meiotic cytokinesis	Actr3	IGI	MGI:MGI:1913963	Mouse	PMID:21494665
Biological Process	GO:0030517	negative regulation of axon extension	Actr3	IMP		Rat	PMID:19846719|RGD:11530054
Biological Process	GO:1904171	negative regulation of bleb assembly	Actr3	IMP		Rat	PMID:22786929|RGD:11571624
Biological Process	GO:0030838	positive regulation of actin filament polymerization	Actr3	IMP		Rat	PMID:18256280|RGD:2306202
Biological Process	GO:0048711	positive regulation of astrocyte differentiation	Actr3	IMP		Rat	PMID:23843614|RGD:8553949
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	Actr3	IMP		Rat	PMID:18430734|RGD:2306201
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	Actr3	IMP		Rat	PMID:23441206|RGD:11530033
Biological Process	GO:0010763	positive regulation of fibroblast migration	Actr3	IMP		Rat	PMID:20566646|RGD:11530051
Biological Process	GO:0051491	positive regulation of filopodium assembly	Actr3	IMP		Rat	PMID:18256280|RGD:2306202
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	ACTR3	IDA		Human	PMID:29058690
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	Actr3	IMP		Rat	PMID:18256280|RGD:2306202
Biological Process	GO:0045666	positive regulation of neuron differentiation	Actr3	IMP		Rat	PMID:18256280|RGD:2306202
Biological Process	GO:0032092	positive regulation of protein binding	Actr3	IMP		Rat	PMID:21844200|RGD:5688279
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	Actr3	IMP		Rat	PMID:21844200|RGD:5688279
Biological Process	GO:0090314	positive regulation of protein targeting to membrane	Actr3	IMP		Rat	PMID:20739464|RGD:10054052
Biological Process	GO:0051965	positive regulation of synapse assembly	Actr3	IMP		Rat	PMID:18430734|RGD:2306201
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ACTR3	IDA		Human	PMID:17220302
Biological Process	GO:0099173	postsynapse organization	Actr3	IDA		Rat	PMID:18430734|RGD:2306201
Biological Process	GO:0099173	postsynapse organization	Actr3	IMP		Rat	PMID:18430734|RGD:2306201
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	Actr3	IDA		Rat	PMID:18430734|RGD:2306201
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	Actr3	IMP		Rat	PMID:18430734|RGD:2306201
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	Actr3	IMP		Rat	PMID:20739464|RGD:10054052
Biological Process	GO:0043519	regulation of myosin II filament organization	Actr3	IMP		Rat	PMID:18256280|RGD:2306202
Biological Process	GO:0032355	response to estradiol	Actr3	IEP		Rat	PMID:19095743|RGD:11530058
Biological Process	GO:0071503	response to heparin	Actr3	IEP		Rat	PMID:17488504|RGD:2306206
Biological Process	GO:0061843	Sertoli cell barrier remodeling	Actr3	IEP		Rat	PMID:20534520|RGD:11530053
Biological Process	GO:0007283	spermatogenesis	Actr3	IEP		Rat	PMID:20534520|RGD:11530053
Biological Process	GO:0051653	spindle localization	Actr3	IGI	MGI:MGI:1913963	Mouse	PMID:21494665

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern