Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACVR1
  • Mouse genes Acvr1
  • Rat genes Acvr1
  • Zfish genes acvr1l
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Acvr1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048185	activin binding	ACVR1	IDA		Human	PMID:8242742
Molecular Function	GO:0048185	activin binding	Acvr1	IPI	PR:P27038	Mouse	PMID:1646080
Molecular Function	GO:0048185	activin binding	Acvr1	IPI	PR:Q04998	Mouse	PMID:7577669
Molecular Function	GO:0016361	activin receptor activity, type I	ACVR1	IDA		Human	PMID:8242742
Molecular Function	GO:0016361	activin receptor activity, type I	Acvr1	IDA		Mouse	PMID:11376112
Molecular Function	GO:0016361	activin receptor activity, type I	Acvr1	IDA		Rat	PMID:8248234|RGD:724761
Molecular Function	GO:0005524	ATP binding	ACVR1	IDA		Human	PMID:12065756
Molecular Function	GO:0045296	cadherin binding	ACVR1	IPI	UniProtKB:P33151	Human	PMID:26598555
Molecular Function	GO:0019838	growth factor binding	Acvr1	IDA		Mouse	PMID:8388127
Molecular Function	GO:0005515	protein binding	ACVR1	IPI	UniProtKB:Q8N6C5	Human	PMID:11266516
Molecular Function	GO:0005515	protein binding	ACVR1	IPI	UniProtKB:P36894	Human	PMID:18436533
Molecular Function	GO:0005515	protein binding	ACVR1	IPI	UniProtKB:Q9UF33	Human	PMID:31483918
Molecular Function	GO:0005515	protein binding	ACVR1	IPI	UniProtKB:P27037	Human	PMID:8242742
Molecular Function	GO:0005515	protein binding	ACVR1	IPI	UniProtKB:P10909	Human	PMID:8555189
Molecular Function	GO:0005515	protein binding	Acvr1	IPI	PR:Q922H7	Mouse	PMID:15239668
Molecular Function	GO:0005515	protein binding	acvr1l	IPI	UniProtKB:O93243	Zfish	PMID:19377468
Molecular Function	GO:0005515	protein binding	acvr1l	IPI	ZFIN:ZDB-GENE-990415-9	Zfish	PMID:19377468
Molecular Function	GO:0042803	protein homodimerization activity	ACVR1	IDA		Human	PMID:18436533
Molecular Function	GO:0004672	protein kinase activity	ACVR1	IDA		Human	PMID:19736306
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ACVR1	IDA		Human	PMID:12065756
Molecular Function	GO:1990782	protein tyrosine kinase binding	ACVR1	IPI	UniProtKB:P12931	Human	PMID:26598555
Molecular Function	GO:0046332	SMAD binding	ACVR1	IDA		Human	PMID:12065756
Molecular Function	GO:0050431	transforming growth factor beta binding	ACVR1	IDA		Human	PMID:8242742
Molecular Function	GO:0050431	transforming growth factor beta binding	Acvr1	IDA		Mouse	PMID:12054694
Molecular Function	GO:0005025	transforming growth factor beta receptor activity, type I	Acvr1	IDA		Mouse	PMID:8388127
Cellular Component	GO:0048179	activin receptor complex	ACVR1	IDA		Human	PMID:8242742
Cellular Component	GO:0048179	activin receptor complex	Acvr1	IDA		Rat	PMID:8248234|RGD:724761
Cellular Component	GO:0045177	apical part of cell	Acvr1	IDA		Mouse	PMID:10704880
Cellular Component	GO:0045177	apical part of cell	Acvr1	IDA		Mouse	PMID:11290335
Cellular Component	GO:0070724	BMP receptor complex	acvr1l	IDA		Zfish	PMID:19377468
Cellular Component	GO:0005938	cell cortex	acvr1l	IDA		Zfish	PMID:18248203
Cellular Component	GO:0005737	cytoplasm	acvr1l	IDA		Zfish	PMID:18248203
Cellular Component	GO:0005886	plasma membrane	ACVR1	IDA		Human	PMID:8242742
Cellular Component	GO:0005886	plasma membrane	Acvr1	IDA		Mouse	PMID:11376112
Cellular Component	GO:0005886	plasma membrane	acvr1l	IDA		Zfish	PMID:32897189
Biological Process	GO:0032924	activin receptor signaling pathway	ACVR1	IMP		Human	PMID:18326817
Biological Process	GO:0032924	activin receptor signaling pathway	ACVR1	IDA		Human	PMID:19506109
Biological Process	GO:0002526	acute inflammatory response	Acvr1	IEP		Mouse	MGI:MGI:3693397|PMID:12151307
Biological Process	GO:0009952	anterior/posterior pattern specification	acvr1l	IMP	ZFIN:ZDB-GENO-980202-960	Zfish	PMID:12482931
Biological Process	GO:0003289	atrial septum primum morphogenesis	ACVR1	IMP		Human	PMID:19506109
Biological Process	GO:0003289	atrial septum primum morphogenesis	Acvr1	IMP		Mouse	MGI:MGI:3610266|PMID:16140292
Biological Process	GO:0003181	atrioventricular valve morphogenesis	Acvr1	IMP		Mouse	MGI:MGI:3610266|PMID:16140292
Biological Process	GO:0030509	BMP signaling pathway	ACVR1	IDA		Human	PMID:18436533
Biological Process	GO:0030509	BMP signaling pathway	acvr1l	IMP	ZFIN:ZDB-MRPHLNO-090610-3	Zfish	PMID:32897189
Biological Process	GO:0030509	BMP signaling pathway	acvr1l	IMP	ZFIN:ZDB-MRPHLNO-060920-2	Zfish	PMID:32897189
Biological Process	GO:0030509	BMP signaling pathway	acvr1l	IGI	ZFIN:ZDB-GENE-000208-25	Zfish	PMID:11222141
Biological Process	GO:0030509	BMP signaling pathway	acvr1l	IGI	ZFIN:ZDB-GENE-980526-474	Zfish	PMID:11222141
Biological Process	GO:0030509	BMP signaling pathway	acvr1l	IGI	ZFIN:ZDB-MRPHLNO-060920-2,ZFIN:ZDB-MRPHLNO-120614-7	Zfish	PMID:22484487
Biological Process	GO:0061312	BMP signaling pathway involved in heart development	Acvr1	IMP		Mouse	MGI:MGI:3610266|PMID:16140292
Biological Process	GO:0007420	brain development	acvr1l	IMP		Zfish	PMID:14648845
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	Acvr1	IMP	MGI:MGI:2386570,MGI:MGI:2651395	Mouse	PMID:17078885
Biological Process	GO:0003230	cardiac atrium development	acvr1l	IMP		Zfish	PMID:19232521
Biological Process	GO:0060923	cardiac muscle cell fate commitment	ACVR1	IMP		Human	PMID:19506109
Biological Process	GO:0051216	cartilage development	acvr1l	IMP		Zfish	PMID:14648845
Biological Process	GO:0071773	cellular response to BMP stimulus	ACVR1	IMP		Human	PMID:18326817
Biological Process	GO:0071385	cellular response to glucocorticoid stimulus	Acvr1	IEP		Rat	PMID:16150914|RGD:2325236
Biological Process	GO:0021556	central nervous system formation	acvr1l	IMP		Zfish	PMID:11165484
Biological Process	GO:0061371	determination of heart left/right asymmetry	acvr1l	IMP	ZFIN:ZDB-GENO-080731-4	Zfish	PMID:21937597
Biological Process	GO:0035462	determination of left/right asymmetry in diencephalon	acvr1l	IMP	ZFIN:ZDB-GENO-080731-4	Zfish	PMID:21937597
Biological Process	GO:0003140	determination of left/right asymmetry in lateral mesoderm	acvr1l	IMP	ZFIN:ZDB-GENO-080731-4	Zfish	PMID:21937597
Biological Process	GO:0007368	determination of left/right symmetry	Acvr1	IMP	MGI:MGI:1931734	Mouse	PMID:15531373
Biological Process	GO:0007368	determination of left/right symmetry	acvr1l	IMP		Zfish	PMID:9334285
Biological Process	GO:0048264	determination of ventral identity	acvr1l	IMP		Zfish	PMID:11165484
Biological Process	GO:0048264	determination of ventral identity	acvr1l	IMP		Zfish	PMID:11222140
Biological Process	GO:0048264	determination of ventral identity	acvr1l	IMP	ZFIN:ZDB-GENO-110804-6	Zfish	PMID:18194657
Biological Process	GO:0048264	determination of ventral identity	acvr1l	IMP		Zfish	PMID:12601179
Biological Process	GO:0048264	determination of ventral identity	acvr1l	IMP	ZFIN:ZDB-GENO-980202-960	Zfish	PMID:11222141
Biological Process	GO:0048264	determination of ventral identity	acvr1l	IMP		Zfish	PMID:9007231
Biological Process	GO:0048264	determination of ventral identity	acvr1l	IMP		Zfish	PMID:16527746
Biological Process	GO:0048264	determination of ventral identity	acvr1l	IDA		Zfish	PMID:11222140
Biological Process	GO:0048264	determination of ventral identity	acvr1l	IMP	ZFIN:ZDB-MRPHLNO-060920-1,ZFIN:ZDB-MRPHLNO-060920-2	Zfish	PMID:11222140
Biological Process	GO:0048264	determination of ventral identity	acvr1l	IMP	ZFIN:ZDB-GENO-980202-960	Zfish	PMID:11222140
Biological Process	GO:0060030	dorsal convergence	acvr1l	IMP	ZFIN:ZDB-MRPHLNO-060920-2	Zfish	PMID:17331724
Biological Process	GO:0009953	dorsal/ventral pattern formation	acvr1l	IMP	ZFIN:ZDB-MRPHLNO-060920-2,ZFIN:ZDB-MRPHLNO-090610-3	Zfish	PMID:19377468
Biological Process	GO:0009953	dorsal/ventral pattern formation	acvr1l	IMP		Zfish	PMID:16775002
Biological Process	GO:0009953	dorsal/ventral pattern formation	acvr1l	IMP		Zfish	PMID:11165484
Biological Process	GO:0009953	dorsal/ventral pattern formation	acvr1l	IGI	ZFIN:ZDB-GENE-980526-527	Zfish	PMID:11165484
Biological Process	GO:0009953	dorsal/ventral pattern formation	acvr1l	IGI	ZFIN:ZDB-GENE-980526-373	Zfish	PMID:12601179
Biological Process	GO:0009953	dorsal/ventral pattern formation	acvr1l	IMP	ZFIN:ZDB-GENO-980202-960	Zfish	PMID:11222141
Biological Process	GO:0009953	dorsal/ventral pattern formation	acvr1l	IMP	ZFIN:ZDB-GENO-980202-960	Zfish	PMID:11969259
Biological Process	GO:0009953	dorsal/ventral pattern formation	acvr1l	IMP	ZFIN:ZDB-GENO-080731-4	Zfish	PMID:19855136
Biological Process	GO:0009953	dorsal/ventral pattern formation	acvr1l	IGI	ZFIN:ZDB-MRPHLNO-060920-2,ZFIN:ZDB-MRPHLNO-120614-7	Zfish	PMID:22484487
Biological Process	GO:0009790	embryo development	Acvr1	IMP		Mouse	PMID:14729481
Biological Process	GO:0009790	embryo development	Acvr1	IMP	MGI:MGI:2447280	Mouse	PMID:15037318
Biological Process	GO:0009790	embryo development	Acvr1	IMP	MGI:MGI:2651395	Mouse	PMID:15037318
Biological Process	GO:0035124	embryonic caudal fin morphogenesis	acvr1l	IMP	ZFIN:ZDB-GENO-980202-960	Zfish	PMID:11222141
Biological Process	GO:0035050	embryonic heart tube development	acvr1l	IMP	ZFIN:ZDB-GENO-080731-4	Zfish	PMID:18267096
Biological Process	GO:0003143	embryonic heart tube morphogenesis	ACVR1	IMP		Human	PMID:19506109
Biological Process	GO:0003143	embryonic heart tube morphogenesis	acvr1l	IMP		Zfish	PMID:9334285
Biological Process	GO:0035162	embryonic hemopoiesis	acvr1l	IMP	ZFIN:ZDB-GENO-060403-1	Zfish	PMID:16527746
Biological Process	GO:0061445	endocardial cushion cell fate commitment	ACVR1	IMP		Human	PMID:19506109
Biological Process	GO:0003274	endocardial cushion fusion	Acvr1	IMP		Mouse	MGI:MGI:3610266|PMID:16140292
Biological Process	GO:0003203	endocardial cushion morphogenesis	Acvr1	IMP		Mouse	MGI:MGI:3610266|PMID:16140292
Biological Process	GO:0007369	gastrulation	Acvr1	IMP	MGI:MGI:1857711	Mouse	PMID:10226013
Biological Process	GO:0001702	gastrulation with mouth forming second	Acvr1	IMP	MGI:MGI:1931734	Mouse	PMID:17117439
Biological Process	GO:0001702	gastrulation with mouth forming second	Acvr1	IMP	MGI:MGI:3696672	Mouse	PMID:17117439
Biological Process	GO:0007281	germ cell development	Acvr1	IMP	MGI:MGI:1857711	Mouse	PMID:15289457
Biological Process	GO:0007507	heart development	Acvr1	IMP	MGI:MGI:2386570,MGI:MGI:2651395	Mouse	PMID:17078885
Biological Process	GO:0007507	heart development	Acvr1	IMP	MGI:MGI:2651395	Mouse	PMID:15226263
Biological Process	GO:0007507	heart development	Acvr1	IMP	MGI:MGI:2136412,MGI:MGI:2651395	Mouse	PMID:16140292
Biological Process	GO:0003146	heart jogging	acvr1l	IMP		Zfish	PMID:9334285
Biological Process	GO:0001947	heart looping	acvr1l	IMP		Zfish	PMID:9334285
Biological Process	GO:0001947	heart looping	acvr1l	IMP	ZFIN:ZDB-GENO-980202-960	Zfish	PMID:17395172
Biological Process	GO:0001701	in utero embryonic development	Acvr1	IMP	MGI:MGI:2651395	Mouse	PMID:15037318
Biological Process	GO:0001701	in utero embryonic development	Acvr1	IMP		Mouse	PMID:14729481
Biological Process	GO:0001701	in utero embryonic development	Acvr1	IMP	MGI:MGI:3696672	Mouse	PMID:17117439
Biological Process	GO:0001701	in utero embryonic development	Acvr1	IMP	MGI:MGI:2447280	Mouse	PMID:15037318
Biological Process	GO:0001701	in utero embryonic development	Acvr1	IMP	MGI:MGI:1931734	Mouse	PMID:17117439
Biological Process	GO:0048368	lateral mesoderm development	acvr1l	IMP		Zfish	PMID:19232521
Biological Process	GO:0001889	liver development	acvr1l	IMP	ZFIN:ZDB-GENO-980202-960	Zfish	PMID:17507405
Biological Process	GO:0007498	mesoderm development	Acvr1	IMP	MGI:MGI:1931734	Mouse	PMID:17117439
Biological Process	GO:0007498	mesoderm development	Acvr1	IMP	MGI:MGI:3696672	Mouse	PMID:17117439
Biological Process	GO:0001707	mesoderm formation	Acvr1	IMP	MGI:MGI:1931734	Mouse	PMID:17117439
Biological Process	GO:0001707	mesoderm formation	Acvr1	IMP	MGI:MGI:1931734	Mouse	PMID:10479450
Biological Process	GO:0001707	mesoderm formation	Acvr1	IMP	MGI:MGI:3696672	Mouse	PMID:17117439
Biological Process	GO:0048332	mesoderm morphogenesis	acvr1l	IMP		Zfish	PMID:11165484
Biological Process	GO:0003183	mitral valve morphogenesis	ACVR1	IMP		Human	PMID:19506109
Biological Process	GO:0032926	negative regulation of activin receptor signaling pathway	ACVR1	IMP		Human	PMID:9884026
Biological Process	GO:0046588	negative regulation of calcium-dependent cell-cell adhesion	acvr1l	IDA		Zfish	PMID:17331724
Biological Process	GO:0046588	negative regulation of calcium-dependent cell-cell adhesion	acvr1l	IMP	ZFIN:ZDB-MRPHLNO-060920-2	Zfish	PMID:17331724
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	ACVR1	IMP		Human	PMID:9884026
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	ACVR1	IMP		Human	PMID:9884026
Biological Process	GO:0009968	negative regulation of signal transduction	ACVR1	IMP		Human	PMID:9884026
Biological Process	GO:0001755	neural crest cell migration	Acvr1	IMP	MGI:MGI:2651395	Mouse	PMID:15226263
Biological Process	GO:0042476	odontogenesis	acvr1l	IEP		Zfish	PMID:14745232
Biological Process	GO:0042476	odontogenesis	acvr1l	IMP		Zfish	PMID:11759004
Biological Process	GO:0001503	ossification	acvr1l	IMP	ZFIN:ZDB-GENO-190109-3	Zfish	PMID:28394244
Biological Process	GO:0060389	pathway-restricted SMAD protein phosphorylation	ACVR1	IDA		Human	PMID:19736306
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ACVR1	IDA		Human	PMID:19736306
Biological Process	GO:0060037	pharyngeal system development	Acvr1	IMP	MGI:MGI:2386570,MGI:MGI:2651395	Mouse	PMID:17078885
Biological Process	GO:0030501	positive regulation of bone mineralization	ACVR1	IMP		Human	PMID:18436533
Biological Process	GO:0030335	positive regulation of cell migration	ACVR1	IGI	UniProtKB:P17813	Human	PMID:19736306
Biological Process	GO:2000017	positive regulation of determination of dorsal identity	ACVR1	IDA		Human	PMID:19506109
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ACVR1	IDA		Human	PMID:8242742
Biological Process	GO:1905007	positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	Acvr1	IMP		Mouse	MGI:MGI:3610266|PMID:16140292
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	ACVR1	IMP		Human	PMID:18436533
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ACVR1	IDA		Human	PMID:19506109
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	Acvr1	IMP		Mouse	MGI:MGI:3610266|PMID:16140292
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ACVR1	IMP		Human	PMID:26598555
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ACVR1	IMP		Human	PMID:18326817
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ACVR1	IDA		Human	PMID:19506109
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Acvr1	IMP		Mouse	MGI:MGI:3610266|PMID:16140292
Biological Process	GO:0003342	proepicardium development	acvr1l	IMP	ZFIN:ZDB-GENO-080731-4	Zfish	PMID:20413782
Biological Process	GO:0006468	protein phosphorylation	ACVR1	IDA		Human	PMID:12065756
Biological Process	GO:0006468	protein phosphorylation	ACVR1	IDA		Human	PMID:19506109
Biological Process	GO:0030510	regulation of BMP signaling pathway	acvr1l	IMP	ZFIN:ZDB-GENO-980202-960	Zfish	PMID:14648845
Biological Process	GO:0030510	regulation of BMP signaling pathway	acvr1l	IGI	ZFIN:ZDB-GENE-980526-373	Zfish	PMID:12601179
Biological Process	GO:0030278	regulation of ossification	ACVR1	IMP		Human	PMID:16642017
Biological Process	GO:0048641	regulation of skeletal muscle tissue development	Acvr1	IEP		Rat	PMID:12968668|RGD:8554636
Biological Process	GO:0051145	smooth muscle cell differentiation	Acvr1	IMP	MGI:MGI:2386570,MGI:MGI:2651395	Mouse	PMID:17078885
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ACVR1	IDA		Human	PMID:8242742
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Acvr1	IDA		Mouse	PMID:11376112
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Acvr1	IMP		Rat	PMID:12968668|RGD:8554636
Biological Process	GO:0001655	urogenital system development	Acvr1	IMP		Rat	PMID:11376112|RGD:8554753
Biological Process	GO:0001944	vasculature development	acvr1l	IMP	ZFIN:ZDB-GENO-980202-960	Zfish	PMID:11222141
Biological Process	GO:0060412	ventricular septum morphogenesis	Acvr1	IMP		Mouse	MGI:MGI:3610266|PMID:16140292

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern