Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACVR1B
  • Mouse genes Acvr1b
  • Rat genes Acvr1b
  • Zfish genes acvr1ba,acvr1bb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Acvr1b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048185	activin binding	ACVR1B	IDA		Human	PMID:12665502
Molecular Function	GO:0048185	activin binding	Acvr1b	IPI	PR:Q04998	Mouse	PMID:7577669
Molecular Function	GO:0017002	activin receptor activity	ACVR1B	IDA		Human	PMID:12665502
Molecular Function	GO:0016361	activin receptor activity, type I	ACVR1B	IDA		Human	PMID:9892009
Molecular Function	GO:0005524	ATP binding	ACVR1B	IDA		Human	PMID:12065756
Molecular Function	GO:0019838	growth factor binding	ACVR1B	IPI	UniProtKB:O14793	Human	PMID:14517293
Molecular Function	GO:0034711	inhibin binding	ACVR1B	IPI	UniProtKB:P08476	Human	PMID:7890768
Molecular Function	GO:0005515	protein binding	ACVR1B	IPI	UniProtKB:Q8N6C5	Human	PMID:11266516
Molecular Function	GO:0005515	protein binding	ACVR1B	IPI	UniProtKB:Q8WUH2	Human	PMID:11278302
Molecular Function	GO:0005515	protein binding	ACVR1B	IPI	UniProtKB:O60749	Human	PMID:11279102
Molecular Function	GO:0005515	protein binding	ACVR1B	IPI	UniProtKB:P36896	Human	PMID:11389842
Molecular Function	GO:0005515	protein binding	ACVR1B	IPI	UniProtKB:P51865	Human	PMID:12052855
Molecular Function	GO:0005515	protein binding	ACVR1B	IPI	UniProtKB:P97766	Human	PMID:12052855
Molecular Function	GO:0005515	protein binding	ACVR1B	IPI	UniProtKB:P13385	Human	PMID:12919325
Molecular Function	GO:0005515	protein binding	ACVR1B	IPI	UniProtKB:O14793	Human	PMID:14517293
Molecular Function	GO:0005515	protein binding	ACVR1B	IPI	UniProtKB:P27040	Human	PMID:14966532
Molecular Function	GO:0005515	protein binding	ACVR1B	IPI	UniProtKB:O15105	Human	PMID:16720724
Molecular Function	GO:0005515	protein binding	ACVR1B	IPI	UniProtKB:P62942	Human	PMID:16720724
Molecular Function	GO:0005515	protein binding	ACVR1B	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	ACVR1B	IPI	UniProtKB:P27037	Human	PMID:8622651
Molecular Function	GO:0005515	protein binding	ACVR1B	IPI	UniProtKB:Q13705	Human	PMID:8622651
Molecular Function	GO:0005515	protein binding	ACVR1B	IPI	UniProtKB:O15105	Human	PMID:9892009
Molecular Function	GO:0005515	protein binding	ACVR1B	IPI	UniProtKB:P84022	Human	PMID:9892009
Molecular Function	GO:0005515	protein binding	ACVR1B	IPI	UniProtKB:Q15796	Human	PMID:9892009
Molecular Function	GO:0005515	protein binding	Acvr1b	IPI	UniProtKB:O95551	Mouse	MGI:MGI:3813431|PMID:18039968
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ACVR1B	EXP		Human	PMID:11389842
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ACVR1B	IDA		Human	PMID:12065756
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ACVR1B	IDA		Human	PMID:18039968
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Acvr1b	IDA		Mouse	MGI:MGI:3813431|PMID:18039968
Molecular Function	GO:0046332	SMAD binding	ACVR1B	IDA		Human	PMID:12065756
Cellular Component	GO:0048179	activin receptor complex	ACVR1B	IDA		Human	PMID:12665502
Cellular Component	GO:0009986	cell surface	ACVR1B	IDA		Human	PMID:12665502
Cellular Component	GO:0005829	cytosol	ACVR1B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ACVR1B	IDA		Human	PMID:9032295
Cellular Component	GO:0043235	receptor complex	ACVR1B	IDA		Human	PMID:14517293
Biological Process	GO:0032924	activin receptor signaling pathway	ACVR1B	IMP		Human	PMID:9884026
Biological Process	GO:0032924	activin receptor signaling pathway	ACVR1B	IDA		Human	PMID:9892009
Biological Process	GO:0032924	activin receptor signaling pathway	Acvr1b	IDA		Mouse	PMID:16115198
Biological Process	GO:0060936	cardiac fibroblast cell development	Acvr1b	IMP		Rat	PMID:27477354|RGD:151665478
Biological Process	GO:0007417	central nervous system development	Acvr1b	IEP		Rat	PMID:8854897|RGD:2315951
Biological Process	GO:0046545	development of primary female sexual characteristics	Acvr1b	IEP		Rat	PMID:11897700|RGD:2315950
Biological Process	GO:0009953	dorsal/ventral pattern formation	acvr1ba	IGI	ZFIN:ZDB-GENE-990415-9	Zfish	PMID:11165484
Biological Process	GO:0009790	embryo development	Acvr1b	IMP	MGI:MGI:1857710	Mouse	PMID:9512518
Biological Process	GO:0001706	endoderm formation	acvr1ba	IDA		Zfish	PMID:16672336
Biological Process	GO:0001706	endoderm formation	acvr1ba	IGI	ZFIN:ZDB-GENO-001214-1	Zfish	PMID:9651684
Biological Process	GO:0007493	endodermal cell fate determination	acvr1ba	IDA		Zfish	PMID:9651684
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	ACVR1B	IMP		Human	PMID:9884026
Biological Process	GO:0031101	fin regeneration	acvr1ba	IMP	ZFIN:ZDB-MRPHLNO-071129-1	Zfish	PMID:17683938
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	ACVR1B	IDA		Human	PMID:11117535
Biological Process	GO:0001942	hair follicle development	Acvr1b	IMP		Mouse	PMID:16127153
Biological Process	GO:0001701	in utero embryonic development	Acvr1b	IMP	MGI:MGI:1857710	Mouse	PMID:15485907
Biological Process	GO:0001701	in utero embryonic development	Acvr1b	IMP	MGI:MGI:1857710	Mouse	PMID:16564040
Biological Process	GO:0001707	mesoderm formation	acvr1ba	IDA		Zfish	PMID:16672336
Biological Process	GO:0001707	mesoderm formation	acvr1ba	IDA		Zfish	PMID:9012495
Biological Process	GO:0030308	negative regulation of cell growth	ACVR1B	IDA		Human	PMID:11117535
Biological Process	GO:0010629	negative regulation of gene expression	Acvr1b	IMP		Mouse	PMID:23152446
Biological Process	GO:0038092	nodal signaling pathway	ACVR1B	IGI	UniProtKB:P43021	Human	PMID:11389842
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ACVR1B	IDA		Human	PMID:18039968
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	Acvr1b	IDA		Mouse	MGI:MGI:3813431|PMID:18039968
Biological Process	GO:0032927	positive regulation of activin receptor signaling pathway	ACVR1B	IDA		Human	PMID:16720724
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	Acvr1b	IMP		Rat	PMID:27477354|RGD:151665478
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation	ACVR1B	IDA		Human	PMID:9032295
Biological Process	GO:0010628	positive regulation of gene expression	Acvr1b	IMP		Mouse	PMID:23152446
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	Acvr1b	IMP		Rat	PMID:17040568|RGD:2315948
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Acvr1b	IMP		Rat	PMID:17040568|RGD:2315948
Biological Process	GO:1901165	positive regulation of trophoblast cell migration	ACVR1B	IDA		Human	PMID:21356369
Biological Process	GO:0046777	protein autophosphorylation	ACVR1B	IDA		Human	PMID:18039968
Biological Process	GO:0006468	protein phosphorylation	ACVR1B	IDA		Human	PMID:12065756
Biological Process	GO:0006355	regulation of DNA-templated transcription	ACVR1B	IDA		Human	PMID:12665502
Biological Process	GO:0006355	regulation of DNA-templated transcription	ACVR1B	IDA		Human	PMID:8622651
Biological Process	GO:0009966	regulation of signal transduction	Acvr1b	IDA		Mouse	PMID:17936261
Biological Process	GO:0014823	response to activity	Acvr1b	IEP		Rat	PMID:22332899|RGD:151665479
Biological Process	GO:0007165	signal transduction	ACVR1B	IDA		Human	PMID:12665502
Biological Process	GO:0007165	signal transduction	ACVR1B	IDA		Human	PMID:8622651

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern