Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACVR1C
  • Mouse genes Acvr1c
  • Rat genes Acvr1c
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Acvr1c

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048185	activin binding	Acvr1c	IDA		Rat	PMID:15196700|RGD:8554721
Molecular Function	GO:0016361	activin receptor activity, type I	ACVR1C	IDA		Human	PMID:12063393
Molecular Function	GO:0016361	activin receptor activity, type I	Acvr1c	IDA		Rat	PMID:8875430|RGD:631881
Molecular Function	GO:0005524	ATP binding	Acvr1c	IDA		Rat	PMID:12065756|RGD:8553317
Molecular Function	GO:0070700	BMP receptor binding	Acvr1c	IDA		Rat	PMID:8940033|RGD:631880
Molecular Function	GO:0019838	growth factor binding	ACVR1C	IPI	UniProtKB:Q9NR23	Human	PMID:21805089
Molecular Function	GO:0038100	nodal binding	ACVR1C	IMP		Human	PMID:21356369
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Acvr1c	IDA		Rat	PMID:12065756|RGD:8553317
Molecular Function	GO:0046332	SMAD binding	Acvr1c	IDA		Rat	PMID:12065756|RGD:8553317
Cellular Component	GO:0048179	activin receptor complex	ACVR1C	IDA		Human	PMID:15531507
Cellular Component	GO:0048179	activin receptor complex	Acvr1c	IDA		Rat	PMID:15196700|RGD:8554721
Cellular Component	GO:0009986	cell surface	Acvr1c	IDA		Rat	PMID:8940033|RGD:631880
Cellular Component	GO:0005737	cytoplasm	Acvr1c	IDA		Rat	PMID:16440210|RGD:2306241
Cellular Component	GO:0005886	plasma membrane	Acvr1c	IDA		Rat	PMID:16440210|RGD:2306241
Biological Process	GO:0030262	apoptotic nuclear changes	ACVR1C	IDA		Human	PMID:15531507
Biological Process	GO:0030154	cell differentiation	ACVR1C	IDA		Human	PMID:15531507
Biological Process	GO:0030154	cell differentiation	Acvr1c	IDA		Rat	PMID:11084022|RGD:8553749
Biological Process	GO:0021549	cerebellum development	Acvr1c	IEP		Rat	PMID:8940033|RGD:631880
Biological Process	GO:0021766	hippocampus development	Acvr1c	IEP		Rat	PMID:8940033|RGD:631880
Biological Process	GO:0030073	insulin secretion	Acvr1c	IMP	MGI:MGI:3512292	Mouse	PMID:18480258
Biological Process	GO:0019915	lipid storage	Acvr1c	IMP	MGI:MGI:3512292	Mouse	PMID:18480258
Biological Process	GO:0030901	midbrain development	Acvr1c	IEP		Rat	PMID:8940033|RGD:631880
Biological Process	GO:1901383	negative regulation of chorionic trophoblast cell proliferation	ACVR1C	IMP		Human	PMID:15150278
Biological Process	GO:0046676	negative regulation of insulin secretion	Acvr1c	IMP	MGI:MGI:3512292	Mouse	PMID:18480258
Biological Process	GO:1901164	negative regulation of trophoblast cell migration	ACVR1C	IDA		Human	PMID:21356369
Biological Process	GO:0038092	nodal signaling pathway	ACVR1C	IMP		Human	PMID:15150278
Biological Process	GO:0001541	ovarian follicle development	Acvr1c	IEP		Rat	PMID:16709598|RGD:2306240
Biological Process	GO:0043065	positive regulation of apoptotic process	ACVR1C	IDA		Human	PMID:15150278
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ACVR1C	IMP		Human	PMID:15150278
Biological Process	GO:0006468	protein phosphorylation	Acvr1c	IDA		Rat	PMID:12065756|RGD:8553317
Biological Process	GO:0042981	regulation of apoptotic process	Acvr1c	IDA		Rat	PMID:11084022|RGD:8553749
Biological Process	GO:0002021	response to dietary excess	Acvr1c	IMP	MGI:MGI:3512292	Mouse	PMID:18480259
Biological Process	GO:0009749	response to glucose	Acvr1c	IMP	MGI:MGI:3512292	Mouse	PMID:18480258
Biological Process	GO:0009749	response to glucose	Acvr1c	IEP		Rat	PMID:16440210|RGD:2306241
Biological Process	GO:0032868	response to insulin	Acvr1c	IMP	MGI:MGI:3512292	Mouse	PMID:18480259
Biological Process	GO:0033993	response to lipid	Acvr1c	IEP		Rat	PMID:16440210|RGD:2306241
Biological Process	GO:0014070	response to organic cyclic compound	Acvr1c	IEP		Rat	PMID:8934566|RGD:2306243
Biological Process	GO:0009410	response to xenobiotic stimulus	Acvr1c	IEP		Rat	PMID:8940033|RGD:631880
Biological Process	GO:0007181	transforming growth factor beta receptor complex assembly	Acvr1c	IDA		Rat	PMID:8940033|RGD:631880
Biological Process	GO:0001834	trophectodermal cell proliferation	ACVR1C	IDA		Human	PMID:15150278

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern