Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Acvr2a

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ACVR2A
- Mouse genes Acvr2a
- Rat genes Acvr2a
- Zfish genes acvr2aa,acvr2ab
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Acvr2a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048185	activin binding	ACVR2A	IPI	UniProtKB:P08476	Human	PMID:9032295
Molecular Function	GO:0048185	activin binding	Acvr2a	IPI	PR:P27038	Mouse	PMID:1646080
Molecular Function	GO:0048185	activin binding	Acvr2a	IDA		Rat	PMID:12385827\|RGD:1579945
Molecular Function	GO:0017002	activin receptor activity	ACVR2A	IDA		Human	PMID:12665502
Molecular Function	GO:0098821	BMP receptor activity	ACVR2A	IDA		Human	PMID:19366699
Molecular Function	GO:0098821	BMP receptor activity	Acvr2a	IMP		Mouse	MGI:MGI:5751611\|PMID:26774823
Molecular Function	GO:0015026	coreceptor activity	ACVR2A	IDA		Human	PMID:10746731
Molecular Function	GO:0019838	growth factor binding	Acvr2a	IMP	UniProtKB:O95390	Mouse	PMID:12414726
Molecular Function	GO:0019838	growth factor binding	Acvr2a	IPI	PR:O08689	Mouse	PMID:11459935
Molecular Function	GO:0034711	inhibin binding	Acvr2a	IPI	UniProtKB:P08476	Mouse	MGI:MGI:3694156\|PMID:7890768
Molecular Function	GO:0034711	inhibin binding	Acvr2a	IDA		Rat	PMID:12385827\|RGD:1579945
Molecular Function	GO:0019209	kinase activator activity	ACVR2A	IDA		Human	PMID:19366699
Molecular Function	GO:0016301	kinase activity	ACVR2A	IDA		Human	PMID:19366699
Molecular Function	GO:0030165	PDZ domain binding	Acvr2a	IPI	UniProtKB:Q9D6K5-3	Mouse	MGI:MGI:3623710\|PMID:16648306
Molecular Function	GO:0005515	protein binding	ACVR2A	IPI	UniProtKB:P05111	Human	PMID:10746731
Molecular Function	GO:0005515	protein binding	ACVR2A	IPI	UniProtKB:Q8N6C5	Human	PMID:11266516
Molecular Function	GO:0005515	protein binding	ACVR2A	IPI	UniProtKB:Q04771	Human	PMID:8242742
Molecular Function	GO:0005515	protein binding	ACVR2A	IPI	UniProtKB:P36896	Human	PMID:8622651
Molecular Function	GO:0005515	protein binding	ACVR2A	IPI	UniProtKB:P05111	Human	PMID:9032295
Molecular Function	GO:0005515	protein binding	ACVR2A	IPI	UniProtKB:P08476	Human	PMID:9032295
Molecular Function	GO:0005515	protein binding	ACVR2A	IPI	UniProtKB:P17813	Human	PMID:9872992
Molecular Function	GO:0005515	protein binding	Acvr2a	IPI	UniProtKB:Q9D6K5-2\|UniProtKB:Q9D6K5-4	Mouse	MGI:MGI:3623710\|PMID:16648306
Molecular Function	GO:0005515	protein binding	Acvr2a	IPI	UniProtKB:Q9WVQ1	Mouse	MGI:MGI:3623710\|PMID:16648306
Molecular Function	GO:0005515	protein binding	Acvr2a	IPI	UniProtKB:P12643	Mouse	MGI:MGI:5921361\|PMID:16672363
Molecular Function	GO:0043621	protein self-association	Acvr2a	IPI	PR:P27038	Mouse	PMID:8612709
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ACVR2A	EXP		Human	PMID:8622651
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ACVR2A	EXP		Human	PMID:8721982
Cellular Component	GO:0009986	cell surface	Acvr2a	IDA		Mouse	MGI:MGI:3623710\|PMID:16648306
Cellular Component	GO:0005737	cytoplasm	ACVR2A	IDA		Human	PMID:14738881
Cellular Component	GO:0034673	inhibin-betaglycan-ActRII complex	ACVR2A	IDA		Human	PMID:10746731
Cellular Component	GO:0043235	receptor complex	ACVR2A	IPI	UniProtKB:P17813	Human	PMID:9872992
Biological Process	GO:0032924	activin receptor signaling pathway	ACVR2A	IMP		Human	PMID:12665502
Biological Process	GO:0032924	activin receptor signaling pathway	ACVR2A	IMP		Human	PMID:18326817
Biological Process	GO:0030325	adrenal gland development	Acvr2a	IEP		Rat	PMID:12844345\|RGD:728125
Biological Process	GO:0009952	anterior/posterior pattern specification	Acvr2a	IGI	MGI:MGI:87912	Mouse	PMID:16991118
Biological Process	GO:0009952	anterior/posterior pattern specification	Acvr2a	IGI	MGI:MGI:87912	Mouse	PMID:10452853
Biological Process	GO:0030509	BMP signaling pathway	ACVR2A	IMP		Human	PMID:17472960
Biological Process	GO:0030509	BMP signaling pathway	ACVR2A	IDA		Human	PMID:18436533
Biological Process	GO:0030509	BMP signaling pathway	ACVR2A	IMP		Human	PMID:19366699
Biological Process	GO:0030509	BMP signaling pathway	Acvr2a	IMP		Mouse	MGI:MGI:5751611\|PMID:26774823
Biological Process	GO:0030509	BMP signaling pathway	Acvr2a	IMP		Mouse	PMID:17472960
Biological Process	GO:0051216	cartilage development	acvr2aa	IMP	ZFIN:ZDB-MRPHLNO-050812-3	Zfish	PMID:15977175
Biological Process	GO:0071773	cellular response to BMP stimulus	ACVR2A	IMP		Human	PMID:18326817
Biological Process	GO:0071773	cellular response to BMP stimulus	ACVR2A	IMP		Human	PMID:19366699
Biological Process	GO:0007368	determination of left/right symmetry	Acvr2a	IGI	MGI:MGI:87912	Mouse	PMID:16991118
Biological Process	GO:0048706	embryonic skeletal system development	Acvr2a	IMP	MGI:MGI:1861779	Mouse	PMID:7885474
Biological Process	GO:0001702	gastrulation with mouth forming second	Acvr2a	IGI	MGI:MGI:87912	Mouse	PMID:10452853
Biological Process	GO:0030902	hindbrain development	acvr2aa	IMP	ZFIN:ZDB-MRPHLNO-050812-3	Zfish	PMID:15977175
Biological Process	GO:0008584	male gonad development	Acvr2a	IMP	MGI:MGI:1861779	Mouse	PMID:7885474
Biological Process	GO:0007498	mesoderm development	Acvr2a	IGI	MGI:MGI:87912	Mouse	PMID:10452853
Biological Process	GO:0001755	neural crest cell migration	acvr2aa	IMP	ZFIN:ZDB-MRPHLNO-050812-3	Zfish	PMID:15977175
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Acvr2a	IGI	MGI:MGI:87912	Mouse	PMID:16330774
Biological Process	GO:0043084	penile erection	Acvr2a	IMP	MGI:MGI:1861779	Mouse	PMID:16093358
Biological Process	GO:0032927	positive regulation of activin receptor signaling pathway	ACVR2A	IDA		Human	PMID:12665502
Biological Process	GO:0030501	positive regulation of bone mineralization	ACVR2A	IMP		Human	PMID:18436533
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation	ACVR2A	IDA		Human	PMID:9032295
Biological Process	GO:0046881	positive regulation of follicle-stimulating hormone secretion	Acvr2a	IMP		Rat	PMID:11861519\|RGD:2325238
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	ACVR2A	IMP		Human	PMID:18436533
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ACVR2A	IMP		Human	PMID:19366699
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ACVR2A	IMP		Human	PMID:17472960
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ACVR2A	IMP		Human	PMID:18326817
Biological Process	GO:0050999	regulation of nitric-oxide synthase activity	Acvr2a	IMP	MGI:MGI:1861779	Mouse	PMID:16093358
Biological Process	GO:0009966	regulation of signal transduction	Acvr2a	IDA		Mouse	PMID:17936261
Biological Process	GO:0010033	response to organic substance	Acvr2a	IEP		Rat	PMID:12706302\|RGD:2325237
Biological Process	GO:0060011	Sertoli cell proliferation	Acvr2a	IMP	MGI:MGI:1861779	Mouse	PMID:11416011
Biological Process	GO:0001501	skeletal system development	acvr2aa	IMP	ZFIN:ZDB-MRPHLNO-050812-3	Zfish	PMID:15977175
Biological Process	GO:0042713	sperm ejaculation	Acvr2a	IMP	MGI:MGI:1861779	Mouse	PMID:16093358
Biological Process	GO:0007283	spermatogenesis	Acvr2a	IGI	MGI:MGI:95582	Mouse	PMID:11459797

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.