Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACVRL1
  • Mouse genes Acvrl1
  • Rat genes Acvrl1
  • Zfish genes acvrl1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Acvrl1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048185	activin binding	ACVRL1	IDA		Human	PMID:8242742
Molecular Function	GO:0016361	activin receptor activity, type I	ACVRL1	IDA		Human	PMID:8242742
Molecular Function	GO:0005524	ATP binding	ACVRL1	IDA		Human	PMID:12065756
Molecular Function	GO:0098821	BMP receptor activity	ACVRL1	IMP		Human	PMID:26176610
Molecular Function	GO:0016301	kinase activity	ACVRL1	IDA		Human	PMID:17068149
Molecular Function	GO:0005515	protein binding	ACVRL1	IPI	UniProtKB:Q8N6C5	Human	PMID:11266516
Molecular Function	GO:0005515	protein binding	ACVRL1	IPI	UniProtKB:Q8WUH2	Human	PMID:11278302
Molecular Function	GO:0005515	protein binding	ACVRL1	IPI	UniProtKB:P55055	Human	PMID:12393874
Molecular Function	GO:0005515	protein binding	ACVRL1	IPI	UniProtKB:P36897	Human	PMID:14580334
Molecular Function	GO:0005515	protein binding	ACVRL1	IPI	UniProtKB:Q86TG7	Human	PMID:15611116
Molecular Function	GO:0005515	protein binding	ACVRL1	IPI	UniProtKB:P17813	Human	PMID:15702480
Molecular Function	GO:0005515	protein binding	ACVRL1	IPI	UniProtKB:Q7Z4P5	Human	PMID:16049014
Molecular Function	GO:0005515	protein binding	ACVRL1	IPI	UniProtKB:O95393	Human	PMID:17068149
Molecular Function	GO:0005515	protein binding	ACVRL1	IPI	UniProtKB:Q9UK05	Human	PMID:17068149
Molecular Function	GO:0005515	protein binding	ACVRL1	IPI	UniProtKB:P17813-1	Human	PMID:18974388
Molecular Function	GO:0005515	protein binding	ACVRL1	IPI	UniProtKB:P02750	Human	PMID:23868260
Molecular Function	GO:0005515	protein binding	ACVRL1	IPI	UniProtKB:Q9UK05:PRO_0000033903	Human	PMID:28564608
Molecular Function	GO:0005515	protein binding	ACVRL1	IPI	UniProtKB:P37173	Human	PMID:8242742
Molecular Function	GO:0005515	protein binding	Acvrl1	IPI	UniProtKB:Q9WV56	Mouse	MGI:MGI:4830635|PMID:20406889
Molecular Function	GO:0005515	protein binding	Acvrl1	IPI	PR:Q64729	Mouse	PMID:14580334
Molecular Function	GO:0019901	protein kinase binding	ACVRL1	IPI	UniProtKB:P67870	Human	PMID:19592636
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ACVRL1	IDA		Human	PMID:12065756
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ACVRL1	IDA		Human	PMID:12393874
Molecular Function	GO:0046332	SMAD binding	ACVRL1	IDA		Human	PMID:12065756
Molecular Function	GO:0050431	transforming growth factor beta binding	ACVRL1	IPI	UniProtKB:P07200	Human	PMID:8242742
Molecular Function	GO:0005024	transforming growth factor beta receptor activity	ACVRL1	IDA		Human	PMID:8242742
Molecular Function	GO:0005025	transforming growth factor beta receptor activity, type I	ACVRL1	IDA		Human	PMID:8242742
Cellular Component	GO:0009986	cell surface	ACVRL1	IDA		Human	PMID:15702480
Cellular Component	GO:0009986	cell surface	ACVRL1	IDA		Human	PMID:8242742
Cellular Component	GO:0009986	cell surface	Acvrl1	IDA		Rat	PMID:15781474|RGD:1579751
Cellular Component	GO:0030425	dendrite	Acvrl1	IDA		Rat	PMID:15781474|RGD:1579751
Cellular Component	GO:0043025	neuronal cell body	Acvrl1	IDA		Rat	PMID:15781474|RGD:1579751
Cellular Component	GO:0005886	plasma membrane	ACVRL1	IDA		Human	PMID:26176610
Cellular Component	GO:0005886	plasma membrane	ACVRL1	IDA		Human	PMID:8242742
Biological Process	GO:0001525	angiogenesis	ACVRL1	IMP		Human	PMID:16752392
Biological Process	GO:0001525	angiogenesis	Acvrl1	IMP	MGI:MGI:2155981	Mouse	PMID:11062473
Biological Process	GO:0001525	angiogenesis	Acvrl1	IMP	MGI:MGI:2155980	Mouse	PMID:10716993
Biological Process	GO:0060840	artery development	Acvrl1	IMP		Mouse	MGI:MGI:4436974|PMID:19903896
Biological Process	GO:0060840	artery development	acvrl1	IGI	RefSeq:NP_055297,ZFIN:ZDB-GENO-081009-3,ZFIN:ZDB-MRPHLNO-060317-4	Zfish	PMID:23863480
Biological Process	GO:0060840	artery development	acvrl1	IMP	ZFIN:ZDB-MRPHLNO-110411-2	Zfish	PMID:23863480
Biological Process	GO:0048844	artery morphogenesis	acvrl1	IMP	ZFIN:ZDB-MRPHLNO-110411-2	Zfish	PMID:25969392
Biological Process	GO:0008015	blood circulation	ACVRL1	IMP		Human	PMID:16752392
Biological Process	GO:0001568	blood vessel development	acvrl1	IMP	ZFIN:ZDB-GENO-100804-1	Zfish	PMID:12050147
Biological Process	GO:0001568	blood vessel development	acvrl1	IMP	ZFIN:ZDB-GENO-110823-2	Zfish	PMID:17911384
Biological Process	GO:0001568	blood vessel development	acvrl1	IMP	ZFIN:ZDB-MRPHLNO-060411-3,ZFIN:ZDB-MRPHLNO-060411-4	Zfish	PMID:12050147
Biological Process	GO:0097746	blood vessel diameter maintenance	acvrl1	IMP	ZFIN:ZDB-GENO-081009-3	Zfish	PMID:21389051
Biological Process	GO:0043534	blood vessel endothelial cell migration	acvrl1	IMP	ZFIN:ZDB-MRPHLNO-110411-2	Zfish	PMID:27287800
Biological Process	GO:0048514	blood vessel morphogenesis	Acvrl1	IMP	MGI:MGI:2680088	Mouse	PMID:17530030
Biological Process	GO:0048514	blood vessel morphogenesis	Acvrl1	IMP	MGI:MGI:2680088	Mouse	PMID:17911384
Biological Process	GO:0048514	blood vessel morphogenesis	acvrl1	IGI	ZFIN:ZDB-MRPHLNO-041217-8,ZFIN:ZDB-MRPHLNO-060411-3,ZFIN:ZDB-MRPHLNO-060411-4	Zfish	PMID:16556914
Biological Process	GO:0048514	blood vessel morphogenesis	acvrl1	IMP	ZFIN:ZDB-MRPHLNO-060411-3,ZFIN:ZDB-MRPHLNO-060411-4	Zfish	PMID:16556914
Biological Process	GO:0048514	blood vessel morphogenesis	acvrl1	IGI	ZFIN:ZDB-MRPHLNO-060411-2,ZFIN:ZDB-MRPHLNO-060411-3,ZFIN:ZDB-MRPHLNO-060411-4	Zfish	PMID:16556914
Biological Process	GO:0001974	blood vessel remodeling	Acvrl1	IMP		Mouse	MGI:MGI:4436974|PMID:19903896
Biological Process	GO:0030509	BMP signaling pathway	ACVRL1	IMP		Human	PMID:19366699
Biological Process	GO:0030509	BMP signaling pathway	Acvrl1	IMP	MGI:MGI:3604490	Mouse	PMID:22783020
Biological Process	GO:0071773	cellular response to BMP stimulus	ACVRL1	IMP		Human	PMID:19366699
Biological Process	GO:0071773	cellular response to BMP stimulus	ACVRL1	IMP		Human	PMID:19903896
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	ACVRL1	IDA		Human	PMID:19494318
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Acvrl1	IDA		Mouse	MGI:MGI:3848261|PMID:19494318
Biological Process	GO:0048264	determination of ventral identity	acvrl1	IDA		Zfish	PMID:12050147
Biological Process	GO:0035912	dorsal aorta morphogenesis	Acvrl1	IMP		Mouse	MGI:MGI:2674189|PMID:12941632
Biological Process	GO:0003203	endocardial cushion morphogenesis	Acvrl1	IMP		Mouse	MGI:MGI:2674189|PMID:12941632
Biological Process	GO:0061154	endothelial tube morphogenesis	ACVRL1	IMP		Human	PMID:19592636
Biological Process	GO:0001701	in utero embryonic development	Acvrl1	IMP	MGI:MGI:2680088	Mouse	PMID:17911384
Biological Process	GO:0001946	lymphangiogenesis	Acvrl1	IMP		Mouse	MGI:MGI:4436974|PMID:19903896
Biological Process	GO:0060836	lymphatic endothelial cell differentiation	ACVRL1	IMP		Human	PMID:19903896
Biological Process	GO:0060836	lymphatic endothelial cell differentiation	Acvrl1	IMP		Mouse	MGI:MGI:4436974|PMID:19903896
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	ACVRL1	IMP		Human	PMID:19592636
Biological Process	GO:0007162	negative regulation of cell adhesion	ACVRL1	IMP		Human	PMID:12453878
Biological Process	GO:0030308	negative regulation of cell growth	ACVRL1	IDA		Human	PMID:17068149
Biological Process	GO:0030336	negative regulation of cell migration	ACVRL1	IMP		Human	PMID:12453878
Biological Process	GO:0008285	negative regulation of cell population proliferation	ACVRL1	IMP		Human	PMID:12453878
Biological Process	GO:2000279	negative regulation of DNA biosynthetic process	ACVRL1	IMP		Human	PMID:19366699
Biological Process	GO:0045602	negative regulation of endothelial cell differentiation	Acvrl1	IDA		Mouse	MGI:MGI:4830635|PMID:20406889
Biological Process	GO:0010596	negative regulation of endothelial cell migration	ACVRL1	IDA		Human	PMID:17068149
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	Acvrl1	IDA		Mouse	MGI:MGI:4830635|PMID:20406889
Biological Process	GO:0051895	negative regulation of focal adhesion assembly	ACVRL1	IMP		Human	PMID:12453878
Biological Process	GO:0010629	negative regulation of gene expression	Acvrl1	IMP		Mouse	MGI:MGI:2674189|PMID:12941632
Biological Process	GO:0045766	positive regulation of angiogenesis	Acvrl1	IGI	MGI:MGI:1924155	Mouse	PMID:23868260
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	ACVRL1	IDA		Human	PMID:17068149
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	Acvrl1	IDA		Mouse	MGI:MGI:4830635|PMID:20406889
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ACVRL1	IDA		Human	PMID:12393874
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Acvrl1	IMP		Mouse	MGI:MGI:4830635|PMID:20406889
Biological Process	GO:0045603	positive regulation of endothelial cell differentiation	Acvrl1	IDA		Mouse	MGI:MGI:4830635|PMID:20406889
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	Acvrl1	IDA		Mouse	MGI:MGI:4830635|PMID:20406889
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ACVRL1	IMP		Human	PMID:19366699
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ACVRL1	IDA		Human	PMID:19366699
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Acvrl1	IMP		Mouse	MGI:MGI:2674189|PMID:12941632
Biological Process	GO:0006468	protein phosphorylation	ACVRL1	IDA		Human	PMID:12065756
Biological Process	GO:0008217	regulation of blood pressure	ACVRL1	IMP		Human	PMID:14684682
Biological Process	GO:0006355	regulation of DNA-templated transcription	ACVRL1	IMP		Human	PMID:15702480
Biological Process	GO:0034405	response to fluid shear stress	acvrl1	IMP	ZFIN:ZDB-GENO-081009-3	Zfish	PMID:21389051
Biological Process	GO:0001666	response to hypoxia	Acvrl1	IEP		Rat	PMID:17515860|RGD:2303144
Biological Process	GO:0061298	retina vasculature development in camera-type eye	Acvrl1	IMP		Mouse	MGI:MGI:4436974|PMID:19903896
Biological Process	GO:0007165	signal transduction	ACVRL1	IDA		Human	PMID:15702480
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ACVRL1	IDA		Human	PMID:15702480
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Acvrl1	IDA		Mouse	PMID:14580334
Biological Process	GO:0001944	vasculature development	acvrl1	IMP	ZFIN:ZDB-MRPHLNO-110411-2	Zfish	PMID:25052553
Biological Process	GO:0060841	venous blood vessel development	Acvrl1	IMP		Mouse	MGI:MGI:4436974|PMID:19903896
Biological Process	GO:0035313	wound healing, spreading of epidermal cells	ACVRL1	IMP		Human	PMID:12453878

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern