Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Adam10

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ADAM10
- Mouse genes Adam10
- Rat genes Adam10
- Zfish genes adam10a,adam10b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adam10

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004175	endopeptidase activity	ADAM10	IMP		Human	PMID:24990881
Molecular Function	GO:0004175	endopeptidase activity	ADAM10	IMP		Human	PMID:28855301
Molecular Function	GO:0004175	endopeptidase activity	ADAM10	IMP		Human	PMID:29430990
Molecular Function	GO:0004175	endopeptidase activity	Adam10	IDA		Mouse	MGI:MGI:6294190\|PMID:17245433
Molecular Function	GO:0004175	endopeptidase activity	Adam10	IMP		Mouse	MGI:MGI:6316556\|PMID:30639848
Molecular Function	GO:0004175	endopeptidase activity	Adam10	IMP		Mouse	MGI:MGI:6294555\|PMID:29430990
Molecular Function	GO:0004175	endopeptidase activity	Adam10	IMP		Mouse	MGI:MGI:6316502\|PMID:29325091
Molecular Function	GO:0004175	endopeptidase activity	Adam10	IDA		Mouse	PMID:12794186
Molecular Function	GO:0070573	metallodipeptidase activity	Adam10	IMP		Mouse	PMID:14993236
Molecular Function	GO:0004222	metalloendopeptidase activity	ADAM10	IDA		Human	PMID:18676862
Molecular Function	GO:0004222	metalloendopeptidase activity	ADAM10	IMP		Human	PMID:19114711
Molecular Function	GO:0004222	metalloendopeptidase activity	Adam10	IDA		Rat	PMID:10423016\|RGD:631800
Molecular Function	GO:1902945	metalloendopeptidase activity involved in amyloid precursor protein catabolic process	ADAM10	IMP		Human	PMID:28164773
Molecular Function	GO:0008237	metallopeptidase activity	ADAM10	IDA		Human	PMID:12475894
Molecular Function	GO:0008237	metallopeptidase activity	ADAM10	IMP		Human	PMID:12535668
Molecular Function	GO:0008237	metallopeptidase activity	Adam10	IDA		Mouse	MGI:MGI:3040545\|PMID:14761956
Molecular Function	GO:0008237	metallopeptidase activity	Adam10	IMP		Mouse	MGI:MGI:3522331\|PMID:12354787
Molecular Function	GO:0008237	metallopeptidase activity	Adam10	IMP		Mouse	PMID:14993236
Molecular Function	GO:0008237	metallopeptidase activity	Adam10	IMP		Mouse	PMID:17079736
Molecular Function	GO:0008237	metallopeptidase activity	Adam10	IMP		Mouse	PMID:31838721
Molecular Function	GO:0060090	molecular adaptor activity	ADAM10	EXP		Human	PMID:25349418
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:Q9UI95	Human	PMID:10527948
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:Q5HYK7-4	Human	PMID:15280379
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:Q5HYK7-5	Human	PMID:15280379
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:Q12959	Human	PMID:17301176
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:O95859	Human	PMID:19587294
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:P60033	Human	PMID:19587294
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:P09616	Human	PMID:20624979
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:O95858	Human	PMID:23091066
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:P21926	Human	PMID:23091066
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:P60033	Human	PMID:23091066
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:P62079	Human	PMID:23091066
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:Q86UF1	Human	PMID:23091066
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:Q8NG11	Human	PMID:23091066
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:Q96FV3	Human	PMID:23091066
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:Q9H1Z9	Human	PMID:23091066
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:P21926	Human	PMID:23289620
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:O94973,UniProtKB:O95782,UniProtKB:P63010,UniProtKB:Q96CW1	Human	PMID:23676497
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:O75791	Human	PMID:25036101
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:P00519	Human	PMID:25036101
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:P06239	Human	PMID:25036101
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:P06241	Human	PMID:25036101
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:P07947	Human	PMID:25036101
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:P08631	Human	PMID:25036101
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:P12931	Human	PMID:25036101
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:P62993	Human	PMID:25036101
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:Q13588	Human	PMID:25036101
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:Q96RF0	Human	PMID:25036101
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:Q99961	Human	PMID:25036101
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:Q9BY11	Human	PMID:25036101
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:Q9UKS6	Human	PMID:25036101
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:Q9UNF0	Human	PMID:25036101
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:O95858	Human	PMID:26686862
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:P21926	Human	PMID:26686862
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:P60033	Human	PMID:26686862
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:P62079	Human	PMID:26686862
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:Q86UF1	Human	PMID:26686862
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:Q8NG11	Human	PMID:26686862
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:Q5VUB5	Human	PMID:30312582
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:P55196	Human	PMID:30463011
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:Q86UF1	Human	PMID:30463011
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:P05067	Human	PMID:30538620
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:P56817	Human	PMID:30538620
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ADAM10	IPI	UniProtKB:P60033	Human	PMID:32900848
Molecular Function	GO:0005515	protein binding	Adam10	IPI	UniProtKB:P17426,UniProtKB:P17427,UniProtKB:P84091,UniProtKB:Q9DBG3	Mouse	MGI:MGI:5514106\|PMID:23676497
Molecular Function	GO:0005515	protein binding	Adam10	IPI	UniProtKB:P56818	Mouse	MGI:MGI:6316502\|PMID:29325091
Molecular Function	GO:0005515	protein binding	Adam10	IPI	UniProtKB:Q9QWV4	Mouse	MGI:MGI:2388865\|PMID:12176995
Molecular Function	GO:0005515	protein binding	Adam10	IPI	PR:Q811D0	Mouse	PMID:17301176
Molecular Function	GO:0042803	protein homodimerization activity	Adam10	IPI	UniProtKB:O35598	Mouse	MGI:MGI:2388865\|PMID:12176995
Molecular Function	GO:0019901	protein kinase binding	Adam10	IDA		Mouse	MGI:MGI:2388865\|PMID:12176995
Cellular Component	GO:0009986	cell surface	ADAM10	IDA		Human	PMID:12475894
Cellular Component	GO:0009986	cell surface	ADAM10	IDA		Human	PMID:23035126
Cellular Component	GO:0009986	cell surface	ADAM10	IDA		Human	PMID:23091066
Cellular Component	GO:0009986	cell surface	Adam10	IDA		Mouse	PMID:28032533
Cellular Component	GO:0009986	cell surface	Adam10	IDA		Rat	PMID:21503882\|RGD:5686904
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Adam10	HDA		Mouse	MGI:MGI:6201853\|PMID:28071719
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Adam10	HDA		Mouse	MGI:MGI:6201834\|PMID:22159717
Cellular Component	GO:0005737	cytoplasm	Adam10	IDA		Mouse	MGI:MGI:2388865\|PMID:12176995
Cellular Component	GO:0030425	dendrite	Adam10	IDA		Rat	PMID:25429624\|RGD:13702878
Cellular Component	GO:0043197	dendritic spine	Adam10	IDA		Rat	PMID:17301176\|RGD:12907557
Cellular Component	GO:0070062	extracellular exosome	ADAM10	HDA		Human	PMID:20458337
Cellular Component	GO:0005925	focal adhesion	ADAM10	HDA		Human	PMID:21423176
Cellular Component	GO:0098978	glutamatergic synapse	Adam10	IDA		Mouse	PMID:21123580
Cellular Component	GO:0098978	glutamatergic synapse	Adam10	EXP		Mouse	PMID:21123580
Cellular Component	GO:0098978	glutamatergic synapse	Adam10	IMP		Mouse	PMID:23083742
Cellular Component	GO:0098978	glutamatergic synapse	Adam10	IDA		Mouse	PMID:23083742
Cellular Component	GO:0098978	glutamatergic synapse	Adam10	IEP		Mouse	PMID:23083742
Cellular Component	GO:0098978	glutamatergic synapse	Adam10	EXP		Mouse	PMID:23083742
Cellular Component	GO:0098978	glutamatergic synapse	Adam10	IDA		Rat	PMID:17301176\|RGD:12907557
Cellular Component	GO:0005794	Golgi apparatus	ADAM10	IDA		Human	PMID:12475894
Cellular Component	GO:0005798	Golgi-associated vesicle	ADAM10	IDA		Human	PMID:12475894
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ADAM10	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	ADAM10	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Adam10	IDA		Rat	PMID:10423016\|RGD:631800
Cellular Component	GO:0043025	neuronal cell body	Adam10	IDA		Rat	PMID:25429624\|RGD:13702878
Cellular Component	GO:0005634	nucleus	Adam10	IDA		Mouse	MGI:MGI:2388865\|PMID:12176995
Cellular Component	GO:0097038	perinuclear endoplasmic reticulum	ADAM10	IDA		Human	PMID:23091066
Cellular Component	GO:0005886	plasma membrane	ADAM10	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ADAM10	IMP		Human	PMID:20624979
Cellular Component	GO:0005886	plasma membrane	ADAM10	IMP		Human	PMID:28164773
Cellular Component	GO:0005886	plasma membrane	Adam10	IDA		Mouse	MGI:MGI:6316502\|PMID:29325091
Cellular Component	GO:0005886	plasma membrane	Adam10	IMP		Mouse	PMID:17079736
Cellular Component	GO:0005886	plasma membrane	Adam10	IMP		Mouse	PMID:14993236
Cellular Component	GO:0046930	pore complex	ADAM10	IMP		Human	PMID:30463011
Cellular Component	GO:0046930	pore complex	Adam10	IMP		Mouse	MGI:MGI:6316557\|PMID:30463011
Cellular Component	GO:0098794	postsynapse	Adam10	IDA		Rat	PMID:17301176\|RGD:12907557
Cellular Component	GO:0098794	postsynapse	Adam10	IDA		Rat	PMID:22328515\|RGD:13703034
Cellular Component	GO:0014069	postsynaptic density	Adam10	IDA		Mouse	PMID:17301176
Cellular Component	GO:0045211	postsynaptic membrane	Adam10	IDA		Rat	PMID:17301176\|RGD:12907557
Cellular Component	GO:0097060	synaptic membrane	ADAM10	IDA		Human	PMID:23676497
Cellular Component	GO:0097060	synaptic membrane	Adam10	IDA		Mouse	MGI:MGI:5514106\|PMID:23676497
Cellular Component	GO:0008021	synaptic vesicle	Adam10	IDA		Rat	PMID:26296617\|RGD:13782154
Cellular Component	GO:0097197	tetraspanin-enriched microdomain	ADAM10	IDA		Human	PMID:23035126
Cellular Component	GO:0005802	trans-Golgi network	Adam10	IDA		Rat	PMID:10423016\|RGD:631800
Biological Process	GO:0034332	adherens junction organization	Adam10	IMP		Mouse	MGI:MGI:6316556\|PMID:30639848
Biological Process	GO:0042987	amyloid precursor protein catabolic process	ADAM10	IMP		Human	PMID:28164773
Biological Process	GO:0034205	amyloid-beta formation	Adam10	IMP		Rat	PMID:17301176\|RGD:12907557
Biological Process	GO:0090102	cochlea development	Adam10	IMP		Mouse	MGI:MGI:6316556\|PMID:30639848
Biological Process	GO:0051089	constitutive protein ectodomain proteolysis	ADAM10	IDA		Human	PMID:12714508
Biological Process	GO:0038004	epidermal growth factor receptor ligand maturation	Adam10	IMP		Mouse	PMID:17079736
Biological Process	GO:0038004	epidermal growth factor receptor ligand maturation	Adam10	IMP		Mouse	PMID:14993236
Biological Process	GO:0001701	in utero embryonic development	Adam10	IMP		Mouse	MGI:MGI:3522331\|PMID:12354787
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM10	IDA		Human	PMID:18355449
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM10	IDA		Human	PMID:12714508
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM10	IDA		Human	PMID:17557115
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM10	IMP		Human	PMID:17965014
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM10	IMP		Human	PMID:18355445
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM10	IMP		Human	PMID:18373975
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM10	IDA		Human	PMID:18419754
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM10	IDA		Human	PMID:18676862
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM10	IDA		Human	PMID:19114711
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM10	IMP		Human	PMID:20711474
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM10	IMP		Human	PMID:24990881
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM10	IMP		Human	PMID:28164773
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM10	IMP		Human	PMID:28855301
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM10	IMP		Human	PMID:29430990
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	Adam10	IMP		Mouse	MGI:MGI:6316556\|PMID:30639848
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	Adam10	IMP		Mouse	MGI:MGI:6294555\|PMID:29430990
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	Adam10	IDA		Mouse	MGI:MGI:6294190\|PMID:17245433
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	Adam10	IMP		Mouse	MGI:MGI:6316502\|PMID:29325091
Biological Process	GO:0042117	monocyte activation	ADAM10	IMP		Human	PMID:11831872
Biological Process	GO:0007162	negative regulation of cell adhesion	ADAM10	IDA		Human	PMID:12714508
Biological Process	GO:0010629	negative regulation of gene expression	ADAM10	IMP		Human	PMID:24530397
Biological Process	GO:0007219	Notch signaling pathway	Adam10	IMP		Mouse	MGI:MGI:3522331\|PMID:12354787
Biological Process	GO:0046931	pore complex assembly	ADAM10	IMP		Human	PMID:30463011
Biological Process	GO:0046931	pore complex assembly	Adam10	IMP		Mouse	MGI:MGI:6316557\|PMID:30463011
Biological Process	GO:0043065	positive regulation of apoptotic process	Adam10	IMP		Rat	PMID:21503882\|RGD:5686904
Biological Process	GO:0030307	positive regulation of cell growth	ADAM10	IMP		Human	PMID:18373975
Biological Process	GO:0030335	positive regulation of cell migration	ADAM10	IMP		Human	PMID:18373975
Biological Process	GO:0008284	positive regulation of cell population proliferation	ADAM10	IMP		Human	PMID:18373975
Biological Process	GO:0010820	positive regulation of T cell chemotaxis	ADAM10	IMP		Human	PMID:18373975
Biological Process	GO:0099173	postsynapse organization	Adam10	IDA		Mouse	PMID:21123580
Biological Process	GO:0099173	postsynapse organization	Adam10	EXP		Mouse	PMID:21123580
Biological Process	GO:0140249	protein catabolic process at postsynapse	Adam10	IMP		Mouse	PMID:23083742
Biological Process	GO:0140249	protein catabolic process at postsynapse	Adam10	IDA		Mouse	PMID:23083742
Biological Process	GO:0140249	protein catabolic process at postsynapse	Adam10	IEP		Mouse	PMID:23083742
Biological Process	GO:0140249	protein catabolic process at postsynapse	Adam10	EXP		Mouse	PMID:23083742
Biological Process	GO:0006468	protein phosphorylation	Adam10	IDA		Mouse	MGI:MGI:2388865\|PMID:12176995
Biological Process	GO:0016485	protein processing	Adam10	IDA		Mouse	PMID:20383322
Biological Process	GO:0061001	regulation of dendritic spine morphogenesis	Adam10	IMP		Rat	PMID:22328515\|RGD:13703034
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	Adam10	IDA		Mouse	PMID:21123580
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	Adam10	EXP		Mouse	PMID:21123580
Biological Process	GO:0008593	regulation of Notch signaling pathway	Adam10	IMP		Mouse	MGI:MGI:6316589\|PMID:29397483
Biological Process	GO:0099175	regulation of postsynapse organization	Adam10	IMP		Mouse	PMID:23083742
Biological Process	GO:0099175	regulation of postsynapse organization	Adam10	IDA		Mouse	PMID:23083742
Biological Process	GO:0099175	regulation of postsynapse organization	Adam10	IEP		Mouse	PMID:23083742
Biological Process	GO:0099175	regulation of postsynapse organization	Adam10	EXP		Mouse	PMID:23083742
Biological Process	GO:1901342	regulation of vasculature development	Adam10	IMP		Mouse	MGI:MGI:6316589\|PMID:29397483
Biological Process	GO:1901342	regulation of vasculature development	Adam10	IMP		Mouse	MGI:MGI:6316900\|PMID:30446855
Biological Process	GO:0097327	response to antineoplastic agent	Adam10	IEP		Rat	PMID:21503882\|RGD:5686904
Biological Process	GO:0034612	response to tumor necrosis factor	ADAM10	IDA		Human	PMID:11831872
Biological Process	GO:0140448	signaling receptor ligand precursor processing	Adam10	IMP		Mouse	PMID:14993236
Biological Process	GO:0140448	signaling receptor ligand precursor processing	Adam10	IMP		Mouse	PMID:31838721
Biological Process	GO:0007283	spermatogenesis	Adam10	IEP		Rat	PMID:25053185\|RGD:13702088
Biological Process	GO:1901998	toxin transport	ADAM10	IMP		Human	PMID:20624979

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/01/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.