Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Adam8

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ADAM8
- Mouse genes Adam8
- Rat genes Adam8
- Zfish genes adam8a,adam8b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adam8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	Adam8	IDA		Mouse	MGI:MGI:2446968\|PMID:12372841
Molecular Function	GO:0050839	cell adhesion molecule binding	ADAM8	IPI	UniProtKB:P10747	Human	PMID:12777399
Molecular Function	GO:0050839	cell adhesion molecule binding	ADAM8	IPI	UniProtKB:P32970	Human	PMID:12777399
Molecular Function	GO:0050839	cell adhesion molecule binding	ADAM8	IPI	UniProtKB:Q9HCX5	Human	PMID:12777399
Molecular Function	GO:0050839	cell adhesion molecule binding	Adam8	IPI	UniProtKB:P25118	Mouse	MGI:MGI:4831059\|PMID:20826683
Molecular Function	GO:0050839	cell adhesion molecule binding	Adam8	IPI	UniProtKB:P05532\|UniProtKB:P13504	Mouse	MGI:MGI:4942254\|PMID:12135759
Molecular Function	GO:0008237	metallopeptidase activity	ADAM8	IDA		Human	PMID:12777399
Molecular Function	GO:0008237	metallopeptidase activity	ADAM8	IDA		Human	PMID:15220135
Molecular Function	GO:0008237	metallopeptidase activity	ADAM8	IDA		Human	PMID:17548643
Molecular Function	GO:0008237	metallopeptidase activity	Adam8	IDA		Mouse	MGI:MGI:3040545\|PMID:14761956
Molecular Function	GO:0008237	metallopeptidase activity	Adam8	IDA		Mouse	MGI:MGI:4942254\|PMID:12135759
Molecular Function	GO:0008237	metallopeptidase activity	Adam8	IDA		Mouse	PMID:12372841
Molecular Function	GO:0008237	metallopeptidase activity	adam8a	IDA		Zfish	PMID:20605457
Molecular Function	GO:0002020	protease binding	adam8a	IPI	ZFIN:ZDB-GENE-120410-1	Zfish	PMID:20605457
Molecular Function	GO:0005515	protein binding	ADAM8	IPI	UniProtKB:P01375	Human	PMID:12777399
Molecular Function	GO:0005515	protein binding	ADAM8	IPI	UniProtKB:O95633	Human	PMID:15574124
Molecular Function	GO:0005515	protein binding	ADAM8	IPI	UniProtKB:P14151	Human	PMID:17548643
Molecular Function	GO:0005515	protein binding	ADAM8	IPI	UniProtKB:P14598	Human	PMID:25825872
Molecular Function	GO:0005515	protein binding	ADAM8	IPI	UniProtKB:P42680	Human	PMID:25825872
Molecular Function	GO:0005515	protein binding	ADAM8	IPI	UniProtKB:Q15642	Human	PMID:25825872
Molecular Function	GO:0005515	protein binding	ADAM8	IPI	UniProtKB:Q5T0N5	Human	PMID:25825872
Molecular Function	GO:0005515	protein binding	Adam8	IPI	UniProtKB:P70232	Mouse	MGI:MGI:3040545\|PMID:14761956
Molecular Function	GO:0005515	protein binding	Adam8	IPI	UniProtKB:P06804	Mouse	MGI:MGI:4942254\|PMID:12135759
Molecular Function	GO:0005515	protein binding	Adam8	IPI	UniProtKB:P04370	Mouse	MGI:MGI:2446968\|PMID:12372841
Molecular Function	GO:0008270	zinc ion binding	Adam8	IDA		Mouse	MGI:MGI:4942254\|PMID:12135759
Molecular Function	GO:0008270	zinc ion binding	Adam8	IDA		Mouse	MGI:MGI:2446968\|PMID:12372841
Cellular Component	GO:0071133	alpha9-beta1 integrin-ADAM8 complex	Adam8	IDA		Mouse	MGI:MGI:3766172\|PMID:16995821
Cellular Component	GO:0009986	cell surface	ADAM8	IDA		Human	PMID:17548643
Cellular Component	GO:0005737	cytoplasm	ADAM8	IDA		Human	PMID:18397961
Cellular Component	GO:0032127	dense core granule membrane	ADAM8	IDA		Human	PMID:17548643
Cellular Component	GO:0032010	phagolysosome	ADAM8	IDA		Human	PMID:17548643
Cellular Component	GO:0005886	plasma membrane	ADAM8	IDA		Human	PMID:17548643
Cellular Component	GO:0005886	plasma membrane	ADAM8	IDA		Human	PMID:18397961
Cellular Component	GO:0005886	plasma membrane	Adam8	IDA		Mouse	PMID:12372841
Cellular Component	GO:0002102	podosome	ADAM8	IDA		Human	PMID:15220135
Cellular Component	GO:0042581	specific granule	ADAM8	IDA		Human	PMID:17548643
Cellular Component	GO:0070820	tertiary granule	ADAM8	IDA		Human	PMID:17548643
Biological Process	GO:0001525	angiogenesis	Adam8	IDA		Mouse	MGI:MGI:5009375\|PMID:19003792
Biological Process	GO:0000902	cell morphogenesis	Adam8	IMP		Mouse	MGI:MGI:5009349\|PMID:20683884
Biological Process	GO:0000902	cell morphogenesis	Adam8	IMP		Mouse	MGI:MGI:5009189\|PMID:11341326
Biological Process	GO:0098609	cell-cell adhesion	Adam8	IDA		Mouse	PMID:12372841
Biological Process	GO:0071456	cellular response to hypoxia	ADAM8	IDA		Human	PMID:18566576
Biological Process	GO:0006954	inflammatory response	ADAM8	IDA		Human	PMID:17548643
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	Adam8	IMP		Mouse	MGI:MGI:5009357\|PMID:20194813
Biological Process	GO:0048247	lymphocyte chemotaxis	Adam8	IDA		Mouse	MGI:MGI:4836302\|PMID:20856819
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Adam8	IDA		Mouse	MGI:MGI:3040545\|PMID:14761956
Biological Process	GO:0002675	positive regulation of acute inflammatory response	Adam8	IMP		Mouse	MGI:MGI:5009765\|PMID:21268008
Biological Process	GO:0045780	positive regulation of bone resorption	Adam8	IMP		Mouse	MGI:MGI:5009349\|PMID:20683884
Biological Process	GO:0045780	positive regulation of bone resorption	Adam8	IDA		Mouse	MGI:MGI:5009189\|PMID:11341326
Biological Process	GO:0045785	positive regulation of cell adhesion	Adam8	IDA		Mouse	MGI:MGI:2446968\|PMID:12372841
Biological Process	GO:0002693	positive regulation of cellular extravasation	Adam8	IMP		Mouse	MGI:MGI:5009357\|PMID:20194813
Biological Process	GO:2000418	positive regulation of eosinophil migration	Adam8	IMP		Mouse	MGI:MGI:5009357\|PMID:20194813
Biological Process	GO:2000415	positive regulation of fibronectin-dependent thymocyte migration	Adam8	IMP		Mouse	MGI:MGI:4836302\|PMID:20856819
Biological Process	GO:0050729	positive regulation of inflammatory response	Adam8	IDA		Mouse	MGI:MGI:5009371\|PMID:19397475
Biological Process	GO:0045089	positive regulation of innate immune response	Adam8	IDA		Mouse	MGI:MGI:5009349\|PMID:20683884
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Adam8	IDA		Mouse	MGI:MGI:5009349\|PMID:20683884
Biological Process	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	ADAM8	IDA		Human	PMID:15220135
Biological Process	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	ADAM8	IDA		Human	PMID:17548643
Biological Process	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	Adam8	IDA		Mouse	MGI:MGI:3040545\|PMID:14761956
Biological Process	GO:2000391	positive regulation of neutrophil extravasation	ADAM8	IDA		Human	PMID:17548643
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Adam8	IDA		Mouse	MGI:MGI:5009349\|PMID:20683884
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Adam8	IDA		Mouse	MGI:MGI:5009349\|PMID:20683884
Biological Process	GO:0033089	positive regulation of T cell differentiation in thymus	Adam8	IDA		Mouse	MGI:MGI:4836302\|PMID:20856819
Biological Process	GO:2000406	positive regulation of T cell migration	Adam8	IMP		Mouse	MGI:MGI:5009357\|PMID:20194813
Biological Process	GO:0070245	positive regulation of thymocyte apoptotic process	Adam8	IMP		Mouse	MGI:MGI:4836302\|PMID:20856819
Biological Process	GO:2000309	positive regulation of tumor necrosis factor (ligand) superfamily member 11 production	Adam8	IMP		Mouse	MGI:MGI:5009349\|PMID:20683884
Biological Process	GO:0022407	regulation of cell-cell adhesion	ADAM8	IDA		Human	PMID:17548643

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.