Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ADAM9
  • Mouse genes Adam9
  • Rat genes Adam9
  • Zfish genes adam9
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adam9

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005518	collagen binding	ADAM9	IMP		Human	PMID:15361064
Molecular Function	GO:0005178	integrin binding	ADAM9	IDA		Human	PMID:15361064
Molecular Function	GO:0005178	integrin binding	ADAM9	IPI	UniProtKB:P05556	Human	PMID:17704059
Molecular Function	GO:0043236	laminin binding	ADAM9	IMP		Human	PMID:15361064
Molecular Function	GO:0004222	metalloendopeptidase activity	ADAM9	IMP		Human	PMID:22480688
Molecular Function	GO:0004222	metalloendopeptidase activity	ADAM9	IDA		Human	PMID:9920899
Molecular Function	GO:0004222	metalloendopeptidase activity	Adam9	IDA		Mouse	MGI:MGI:5431199|PMID:22480688
Molecular Function	GO:0008237	metallopeptidase activity	ADAM9	IMP		Human	PMID:12535668
Molecular Function	GO:0005515	protein binding	ADAM9	IPI	UniProtKB:Q9UI95	Human	PMID:10527948
Molecular Function	GO:0005515	protein binding	ADAM9	IPI	UniProtKB:Q99962	Human	PMID:10531379
Molecular Function	GO:0005515	protein binding	ADAM9	IPI	UniProtKB:Q9UI95	Human	PMID:10531379
Molecular Function	GO:0005515	protein binding	ADAM9	IPI	UniProtKB:Q9UKS6	Human	PMID:10531379
Molecular Function	GO:0005515	protein binding	ADAM9	IPI	UniProtKB:P05067	Human	PMID:12054541
Molecular Function	GO:0005515	protein binding	ADAM9	IPI	UniProtKB:Q5HYK7-4	Human	PMID:15280379
Molecular Function	GO:0005515	protein binding	ADAM9	IPI	UniProtKB:Q5HYK7-5	Human	PMID:15280379
Molecular Function	GO:0005515	protein binding	ADAM9	IPI	UniProtKB:Q96RF0	Human	PMID:25825872
Molecular Function	GO:0005515	protein binding	Adam9	IPI	UniProtKB:Q99962|UniProtKB:Q9Y5X1	Mouse	MGI:MGI:3687666|PMID:10531379
Molecular Function	GO:0005515	protein binding	Adam9	IPI	UniProtKB:Q61739	Mouse	MGI:MGI:5784998|PMID:10825303
Molecular Function	GO:0005080	protein kinase C binding	Adam9	IPI	UniProtKB:Q02111	Mouse	MGI:MGI:1326990|PMID:9857183
Molecular Function	GO:0017124	SH3 domain binding	ADAM9	IPI	UniProtKB:Q99962	Human	PMID:10531379
Molecular Function	GO:0017124	SH3 domain binding	ADAM9	IPI	UniProtKB:Q9Y5X1	Human	PMID:10531379
Molecular Function	GO:0017124	SH3 domain binding	Adam9	IDA		Mouse	MGI:MGI:78959|PMID:8647900
Cellular Component	GO:0016323	basolateral plasma membrane	Adam9	IDA		Rat	PMID:10752518|RGD:632497
Cellular Component	GO:0009986	cell surface	Adam9	IDA		Mouse	MGI:MGI:78959|PMID:8647900
Cellular Component	GO:0009986	cell surface	Adam9	IDA		Rat	PMID:10752518|RGD:632497
Cellular Component	GO:0009986	cell surface	Adam9	IDA		Rat	PMID:21503882|RGD:5686904
Cellular Component	GO:0005737	cytoplasm	Adam9	IDA		Mouse	PMID:15739225
Cellular Component	GO:0009897	external side of plasma membrane	Adam9	IDA		Mouse	MGI:MGI:3828418|PMID:9920899
Cellular Component	GO:0070062	extracellular exosome	ADAM9	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	Adam9	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Adam9	IMP		Mouse	MGI:MGI:3828418|PMID:9920899
Cellular Component	GO:0005925	focal adhesion	ADAM9	HDA		Human	PMID:21423176
Cellular Component	GO:0005886	plasma membrane	Adam9	IDA		Mouse	PMID:15739225
Biological Process	GO:0007155	cell adhesion	ADAM9	IMP		Human	PMID:11162558
Biological Process	GO:0007155	cell adhesion	ADAM9	IMP		Human	PMID:17704059
Biological Process	GO:0033627	cell adhesion mediated by integrin	ADAM9	IMP		Human	PMID:17704059
Biological Process	GO:0033627	cell adhesion mediated by integrin	Adam9	IDA		Mouse	MGI:MGI:5784998|PMID:10825303
Biological Process	GO:0016477	cell migration	Adam9	IDA		Mouse	MGI:MGI:5784998|PMID:10825303
Biological Process	GO:0033631	cell-cell adhesion mediated by integrin	ADAM9	IEP		Human	PMID:17704059
Biological Process	GO:0007160	cell-matrix adhesion	ADAM9	IMP		Human	PMID:15361064
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ADAM9	IMP		Human	PMID:22480688
Biological Process	GO:0030216	keratinocyte differentiation	ADAM9	IEP		Human	PMID:17704059
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM9	IMP		Human	PMID:23437250
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM9	IMP		Human	PMID:22480688
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM9	IDA		Human	PMID:9920899
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	Adam9	IDA		Mouse	MGI:MGI:5431199|PMID:22480688
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	Adam9	IDA		Mouse	MGI:MGI:3847362|PMID:19273593
Biological Process	GO:0031293	membrane protein intracellular domain proteolysis	ADAM9	IMP		Human	PMID:23437250
Biological Process	GO:0042117	monocyte activation	ADAM9	IMP		Human	PMID:11831872
Biological Process	GO:0033630	positive regulation of cell adhesion mediated by integrin	ADAM9	IMP		Human	PMID:11162558
Biological Process	GO:0030335	positive regulation of cell migration	ADAM9	IDA		Human	PMID:23437250
Biological Process	GO:0051549	positive regulation of keratinocyte migration	ADAM9	IMP		Human	PMID:17704059
Biological Process	GO:0034241	positive regulation of macrophage fusion	ADAM9	IMP		Human	PMID:11831872
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ADAM9	IDA		Human	PMID:17704059
Biological Process	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	Adam9	IDA		Mouse	MGI:MGI:1326990|PMID:9857183
Biological Process	GO:0050714	positive regulation of protein secretion	ADAM9	IDA		Human	PMID:17704059
Biological Process	GO:0097327	response to antineoplastic agent	Adam9	IEP		Rat	PMID:21503882|RGD:5686904
Biological Process	GO:0051592	response to calcium ion	ADAM9	IMP		Human	PMID:11162558
Biological Process	GO:0051384	response to glucocorticoid	Adam9	IMP		Mouse	MGI:MGI:3828402|PMID:16311053
Biological Process	GO:0042542	response to hydrogen peroxide	ADAM9	IMP		Human	PMID:17018608
Biological Process	GO:0034616	response to laminar fluid shear stress	Adam9	IEP		Rat	PMID:11156854|RGD:2325252
Biological Process	GO:0010042	response to manganese ion	ADAM9	IMP		Human	PMID:11162558
Biological Process	GO:0034612	response to tumor necrosis factor	ADAM9	IDA		Human	PMID:11831872
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ADAM9	IMP		Human	PMID:11955914
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Adam9	IMP		Mouse	MGI:MGI:3828410|PMID:11955914

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern