Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ADAR
  • Mouse genes Adar
  • Rat genes Adar
  • Zfish genes adar
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adar

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003726	double-stranded RNA adenosine deaminase activity	ADAR	IDA		Human	PMID:9020165
Molecular Function	GO:0005515	protein binding	ADAR	IPI	UniProtKB:P19525	Human	PMID:18362360
Molecular Function	GO:0005515	protein binding	ADAR	IPI	UniProtKB:Q92900	Human	PMID:18362360
Molecular Function	GO:0005515	protein binding	ADAR	IPI	UniProtKB:P03496	Human	PMID:22810585
Molecular Function	GO:0005515	protein binding	ADAR	IPI	UniProtKB:P03496	Human	PMID:23853584
Molecular Function	GO:0005515	protein binding	ADAR	IPI	UniProtKB:P14340:PRO_0000037965	Human	PMID:23853584
Molecular Function	GO:0005515	protein binding	ADAR	IPI	UniProtKB:Q99IB8:PRO_0000045599	Human	PMID:24136289
Molecular Function	GO:0005515	protein binding	ADAR	IPI	UniProtKB:Q08211	Human	PMID:28355180
Molecular Function	GO:0005515	protein binding	ADAR	IPI	UniProtKB:Q13148	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Adar	IPI	UniProtKB:O70133	Mouse	MGI:MGI:5908757|PMID:28355180
Molecular Function	GO:0005515	protein binding	Adar	IPI	UniProtKB:Q03963	Mouse	MGI:MGI:5447606|PMID:18362360
Molecular Function	GO:0005515	protein binding	Adar	IPI	PR:P59328	Mouse	PMID:21266480
Molecular Function	GO:0003723	RNA binding	ADAR	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	ADAR	HDA		Human	PMID:22681889
Cellular Component	GO:0005737	cytoplasm	ADAR	IDA		Human	PMID:23622242
Cellular Component	GO:0005737	cytoplasm	Adar	IDA		Mouse	PMID:14613934
Cellular Component	GO:0016020	membrane	ADAR	HDA		Human	PMID:19946888
Cellular Component	GO:0016607	nuclear speck	Adar	IDA		Rat	PMID:12665561|RGD:10755332
Cellular Component	GO:0005730	nucleolus	ADAR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	Adar	IDA		Mouse	PMID:14613934
Cellular Component	GO:0005730	nucleolus	Adar	IDA		Rat	PMID:12665561|RGD:10755332
Cellular Component	GO:0005654	nucleoplasm	ADAR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ADAR	IDA		Human	PMID:18362360
Cellular Component	GO:0005634	nucleus	ADAR	IDA		Human	PMID:23622242
Cellular Component	GO:0005634	nucleus	Adar	IDA		Mouse	PMID:14613934
Cellular Component	GO:0044530	supraspliceosomal complex	ADAR	IDA		Human	PMID:18362360
Biological Process	GO:0006382	adenosine to inosine editing	ADAR	IDA		Human	PMID:15858013
Biological Process	GO:0006382	adenosine to inosine editing	ADAR	IMP		Human	PMID:16475990
Biological Process	GO:0006382	adenosine to inosine editing	ADAR	IDA		Human	PMID:19651874
Biological Process	GO:0006382	adenosine to inosine editing	ADAR	IDA		Human	PMID:21289159
Biological Process	GO:0006382	adenosine to inosine editing	Adar	IDA		Mouse	MGI:MGI:5447614|PMID:17369310
Biological Process	GO:0006382	adenosine to inosine editing	Adar	IMP	MGI:MGI:3029789	Mouse	PMID:14615479
Biological Process	GO:0008595	anterior/posterior axis specification, embryo	adar	IMP	ZFIN:ZDB-MRPHLNO-230124-1	Zfish	PMID:36127363
Biological Process	GO:0006915	apoptotic process	Adar	IMP	MGI:MGI:2176228,MGI:MGI:3032439,MGI:MGI:3032487	Mouse	PMID:14613934
Biological Process	GO:0016553	base conversion or substitution editing	ADAR	IDA		Human	PMID:9020165
Biological Process	GO:0098586	cellular response to virus	Adar	IDA		Mouse	MGI:MGI:5645191|PMID:24882218
Biological Process	GO:0060216	definitive hemopoiesis	Adar	IMP	MGI:MGI:3029789	Mouse	PMID:14615479
Biological Process	GO:0030218	erythrocyte differentiation	Adar	IMP	MGI:MGI:5436438	Mouse	PMID:11099415
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	Adar	IMP	MGI:MGI:2182767,MGI:MGI:3032439	Mouse	PMID:19805087
Biological Process	GO:0061484	hematopoietic stem cell homeostasis	Adar	IMP	MGI:MGI:3828307	Mouse	PMID:19060901
Biological Process	GO:0097284	hepatocyte apoptotic process	Adar	IMP	MGI:MGI:2176228,MGI:MGI:3032439,MGI:MGI:3032487	Mouse	PMID:14613934
Biological Process	GO:0035196	miRNA processing	Adar	IMP	MGI:MGI:3032487	Mouse	PMID:23622242
Biological Process	GO:1903944	negative regulation of hepatocyte apoptotic process	Adar	IMP	MGI:MGI:2176228,MGI:MGI:3032439,MGI:MGI:3032487	Mouse	PMID:14613934
Biological Process	GO:1900369	negative regulation of post-transcriptional gene silencing by RNA	Adar	IMP		Mouse	PMID:15556947
Biological Process	GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation	ADAR	IMP		Human	PMID:18362360
Biological Process	GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation	ADAR	IDA		Human	PMID:19651874
Biological Process	GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation	Adar	IMP		Mouse	MGI:MGI:5447606|PMID:18362360
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	Adar	IMP	MGI:MGI:3828307	Mouse	PMID:19060901
Biological Process	GO:0001649	osteoblast differentiation	Adar	IMP	MGI:MGI:2182767,MGI:MGI:3032439	Mouse	PMID:23123729
Biological Process	GO:0045070	positive regulation of viral genome replication	ADAR	IMP		Human	PMID:18362360
Biological Process	GO:0045070	positive regulation of viral genome replication	ADAR	IDA		Human	PMID:19651874
Biological Process	GO:0045070	positive regulation of viral genome replication	Adar	IMP		Mouse	MGI:MGI:5447606|PMID:18362360
Biological Process	GO:0031054	pre-miRNA processing	ADAR	IDA		Human	PMID:23622242
Biological Process	GO:0035455	response to interferon-alpha	ADAR	IDA		Human	PMID:16475990
Biological Process	GO:0009615	response to virus	ADAR	IMP		Human	PMID:15858013
Biological Process	GO:0070922	RISC complex assembly	ADAR	IDA		Human	PMID:23622242
Biological Process	GO:0002566	somatic diversification of immune receptors via somatic mutation	Adar	IDA		Mouse	PMID:23209284

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern