Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ADCY1
  • Mouse genes Adcy1
  • Rat genes Adcy1
  • Zfish genes adcy1a,adcy1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adcy1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy1	IGI	MGI:MGI:1341110	Mouse	PMID:10482244
Molecular Function	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	Adcy1	IDA		Rat	PMID:14985420|RGD:2312640
Cellular Component	GO:0005737	cytoplasm	Adcy1	IDA		Mouse	MGI:MGI:5586779|PMID:24482543
Cellular Component	GO:0070062	extracellular exosome	ADCY1	HDA		Human	PMID:19056867
Cellular Component	GO:0098978	glutamatergic synapse	Adcy1	IMP		Mouse	PMID:9547227
Cellular Component	GO:0098978	glutamatergic synapse	Adcy1	IDA		Mouse	PMID:9547227
Cellular Component	GO:0098978	glutamatergic synapse	Adcy1	IMP		Mouse	PMID:10482244
Cellular Component	GO:0098978	glutamatergic synapse	Adcy1	IDA		Mouse	PMID:10482244
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Adcy1	IDA		Mouse	PMID:9547227
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Adcy1	IMP		Mouse	PMID:9547227
Cellular Component	GO:0005634	nucleus	Adcy1	IDA		Rat	PMID:11457491|RGD:2312581
Cellular Component	GO:0005886	plasma membrane	ADCY1	IDA		Human	PMID:11549699
Cellular Component	GO:0014069	postsynaptic density	Adcy1	IDA		Mouse	MGI:MGI:3790159|PMID:18448650
Cellular Component	GO:0098839	postsynaptic density membrane	Adcy1	IDA		Mouse	PMID:17335981
Cellular Component	GO:0098839	postsynaptic density membrane	Adcy1	IEP		Mouse	PMID:17335981
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Adcy1	IMP		Mouse	PMID:10482244
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Adcy1	IDA		Mouse	PMID:10482244
Biological Process	GO:0016199	axon midline choice point recognition	adcy1b	IGI	ZFIN:ZDB-MRPHLNO-100622-1,ZFIN:ZDB-MRPHLNO-100622-2,ZFIN:ZDB-MRPHLNO-100805-5,ZFIN:ZDB-MRPHLNO-100805-6	Zfish	PMID:20505109
Biological Process	GO:0007409	axonogenesis	Adcy1	IMP	MGI:MGI:1857775	Mouse	PMID:17229090
Biological Process	GO:0007420	brain development	Adcy1	IEP		Rat	PMID:9003034|RGD:13464137
Biological Process	GO:0006171	cAMP biosynthetic process	Adcy1	IDA		Rat	PMID:14985420|RGD:2312640
Biological Process	GO:0007623	circadian rhythm	Adcy1	IEP		Rat	PMID:8855334|RGD:1625750
Biological Process	GO:0007616	long-term memory	Adcy1	IGI	MGI:MGI:1341110	Mouse	PMID:10482244
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Adcy1	IMP		Mouse	PMID:10482244
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Adcy1	IDA		Mouse	PMID:10482244
Biological Process	GO:0150076	neuroinflammatory response	Adcy1	IMP		Mouse	MGI:MGI:3621665|PMID:12441059
Biological Process	GO:0032793	positive regulation of CREB transcription factor activity	Adcy1	IMP		Mouse	MGI:MGI:3621665|PMID:12441059
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	Adcy1	IMP		Mouse	MGI:MGI:1344240|PMID:10482244
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Adcy1	IDA		Mouse	PMID:9547227
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Adcy1	IMP		Mouse	PMID:9547227
Biological Process	GO:0042752	regulation of circadian rhythm	Adcy1	IMP		Mouse	MGI:MGI:5518489|PMID:24048828
Biological Process	GO:0010226	response to lithium ion	Adcy1	IEP		Rat	PMID:10706991|RGD:1625751
Biological Process	GO:0009410	response to xenobiotic stimulus	Adcy1	IEP		Rat	PMID:10706991|RGD:1625751
Biological Process	GO:0031290	retinal ganglion cell axon guidance	adcy1b	IGI	ZFIN:ZDB-MRPHLNO-100622-1,ZFIN:ZDB-MRPHLNO-100622-2,ZFIN:ZDB-MRPHLNO-100805-5,ZFIN:ZDB-MRPHLNO-100805-6	Zfish	PMID:20505109
Biological Process	GO:0007605	sensory perception of sound	adcy1b	IMP	ZFIN:ZDB-MRPHLNO-100805-5	Zfish	PMID:24482543

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern