Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ADCY2
  • Mouse genes Adcy2
  • Rat genes Adcy2
  • Zfish genes adcy2a,adcy2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adcy2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy2	IDA		Rat	PMID:10427002|RGD:10400857
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy2	IDA		Rat	PMID:11738086|RGD:2312641
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy2	IDA		Rat	PMID:12711600|RGD:2312674
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy2	IDA		Rat	PMID:1719547|RGD:724792
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy2	IDA		Rat	PMID:18164588|RGD:8553431
Molecular Function	GO:0008179	adenylate cyclase binding	Adcy2	IPI	UniProtKB:P84309	Mouse	MGI:MGI:5318025|PMID:18164588
Molecular Function	GO:0008179	adenylate cyclase binding	Adcy2	IDA		Rat	PMID:18164588|RGD:8553431
Molecular Function	GO:0031683	G-protein beta/gamma-subunit complex binding	Adcy2	IPI	RGD:69319	Rat	PMID:16967511|RGD:1601381
Molecular Function	GO:0000287	magnesium ion binding	Adcy2	IDA		Rat	PMID:10427002|RGD:10400857
Molecular Function	GO:0030145	manganese ion binding	Adcy2	IDA		Rat	PMID:10427002|RGD:10400857
Molecular Function	GO:0005515	protein binding	Adcy2	IPI	UniProtKB:Q99996-4	Rat	PMID:18772391|RGD:2313147
Molecular Function	GO:0005515	protein binding	Adcy2	IPI	UniProtKB:Q08499-2	Rat	PMID:20664520|RGD:8553331
Cellular Component	GO:0005737	cytoplasm	ADCY2	IDA		Human	PMID:11549699
Cellular Component	GO:0030425	dendrite	Adcy2	IDA		Mouse	PMID:9870949
Cellular Component	GO:0016020	membrane	Adcy2	IDA		Mouse	PMID:9870949
Cellular Component	GO:0016020	membrane	Adcy2	IDA		Rat	PMID:18164588|RGD:8553431
Cellular Component	GO:0045121	membrane raft	Adcy2	IDA		Rat	PMID:18164588|RGD:8553431
Cellular Component	GO:0005886	plasma membrane	ADCY2	IDA		Human	PMID:11549699
Cellular Component	GO:0005886	plasma membrane	Adcy2	IDA		Mouse	MGI:MGI:5318025|PMID:18164588
Cellular Component	GO:0005886	plasma membrane	Adcy2	IDA		Rat	PMID:18164588|RGD:8553431
Cellular Component	GO:0005886	plasma membrane	Adcy2	IDA		Rat	PMID:7761832|RGD:10400854
Cellular Component	GO:0032991	protein-containing complex	Adcy2	IDA		Rat	PMID:16967511|RGD:1601381
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Adcy2	IDA		Rat	PMID:7761832|RGD:10400854
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	Adcy2	IDA		Rat	PMID:18164588|RGD:8553431
Biological Process	GO:0036302	atrioventricular canal development	adcy2a	IMP	ZFIN:ZDB-MRPHLNO-210329-1	Zfish	PMID:32859249
Biological Process	GO:0036302	atrioventricular canal development	adcy2a	IMP	ZFIN:ZDB-MRPHLNO-210329-4	Zfish	PMID:32859249
Biological Process	GO:0006171	cAMP biosynthetic process	Adcy2	IDA		Rat	PMID:10427002|RGD:10400857
Biological Process	GO:0006171	cAMP biosynthetic process	Adcy2	IDA		Rat	PMID:11738086|RGD:2312641
Biological Process	GO:0006171	cAMP biosynthetic process	Adcy2	IDA		Rat	PMID:12711600|RGD:2312674
Biological Process	GO:0006171	cAMP biosynthetic process	Adcy2	IDA		Rat	PMID:18164588|RGD:8553431
Biological Process	GO:0019933	cAMP-mediated signaling	Adcy2	IDA		Rat	PMID:7761832|RGD:10400854
Biological Process	GO:1904322	cellular response to forskolin	Adcy2	IDA		Rat	PMID:1719547|RGD:724792
Biological Process	GO:0061371	determination of heart left/right asymmetry	adcy2a	IMP	ZFIN:ZDB-MRPHLNO-210329-1	Zfish	PMID:32859249
Biological Process	GO:0061371	determination of heart left/right asymmetry	adcy2a	IMP	ZFIN:ZDB-MRPHLNO-210329-4	Zfish	PMID:32859249

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern