Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ADCY5
  • Mouse genes Adcy5
  • Rat genes Adcy5
  • Zfish genes adcy5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adcy5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004016	adenylate cyclase activity	ADCY5	IDA		Human	PMID:15385642
Molecular Function	GO:0004016	adenylate cyclase activity	ADCY5	IDA		Human	PMID:24700542
Molecular Function	GO:0004016	adenylate cyclase activity	ADCY5	IMP		Human	PMID:24740569
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy5	IDA		Mouse	PMID:17593019
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy5	IMP	MGI:MGI:2387896	Mouse	PMID:12223546
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy5	IMP	MGI:MGI:2662295	Mouse	PMID:12665504
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy5	IMP		Mouse	PMID:19574217
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy5	IDA		Rat	PMID:11738086|RGD:2312641
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy5	IDA		Rat	PMID:12711600|RGD:2312674
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy5	IDA		Rat	PMID:1409703|RGD:69740
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy5	IDA		Rat	PMID:17010343|RGD:2315004
Molecular Function	GO:0008179	adenylate cyclase binding	Adcy5	IPI	UniProtKB:Q80TL1	Mouse	MGI:MGI:5318025|PMID:18164588
Molecular Function	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	Adcy5	IDA		Rat	PMID:10894801|RGD:2315006
Molecular Function	GO:0005515	protein binding	Adcy5	IPI	UniProtKB:O35245	Mouse	MGI:MGI:5014446|PMID:21670265
Molecular Function	GO:0005515	protein binding	Adcy5	IPI	PR:Q3TIR3	Mouse	PMID:17593019
Molecular Function	GO:0097110	scaffold protein binding	Adcy5	IPI	PR:Q2VEB3	Mouse	PMID:19574217
Cellular Component	GO:0005929	cilium	Adcy5	IDA		Mouse	MGI:MGI:5014446|PMID:21670265
Cellular Component	GO:0005768	endosome	Adcy5	IDA		Rat	PMID:17010343|RGD:2315004
Cellular Component	GO:0016020	membrane	ADCY5	IDA		Human	PMID:15385642
Cellular Component	GO:0016020	membrane	Adcy5	IDA		Mouse	PMID:17593019
Cellular Component	GO:0045121	membrane raft	Adcy5	IDA		Rat	PMID:12573460|RGD:2312526
Cellular Component	GO:0005886	plasma membrane	Adcy5	IDA		Mouse	MGI:MGI:5318025|PMID:18164588
Cellular Component	GO:0005886	plasma membrane	Adcy5	IDA		Mouse	PMID:12665504
Cellular Component	GO:0005886	plasma membrane	Adcy5	IDA		Rat	PMID:16284070|RGD:2312675
Cellular Component	GO:0005886	plasma membrane	Adcy5	IDA		Rat	PMID:17010343|RGD:2315004
Cellular Component	GO:0042383	sarcolemma	Adcy5	IDA		Rat	PMID:15961389|RGD:1598749
Biological Process	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	Adcy5	IGI	MGI:MGI:99578	Mouse	PMID:12223546
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ADCY5	IMP		Human	PMID:24700542
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Adcy5	IGI	MGI:MGI:99402	Mouse	PMID:12223546
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Adcy5	IMP		Rat	PMID:19549762|RGD:2316039
Biological Process	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	Adcy5	IGI	MGI:MGI:94924	Mouse	PMID:12223546
Biological Process	GO:0007568	aging	Adcy5	IEP		Rat	PMID:19734365|RGD:13464133
Biological Process	GO:0007420	brain development	Adcy5	IEP		Rat	PMID:9003034|RGD:13464137
Biological Process	GO:0006171	cAMP biosynthetic process	ADCY5	IDA		Human	PMID:15385642
Biological Process	GO:0006171	cAMP biosynthetic process	ADCY5	IDA		Human	PMID:24700542
Biological Process	GO:0006171	cAMP biosynthetic process	ADCY5	IMP		Human	PMID:24740569
Biological Process	GO:0006171	cAMP biosynthetic process	Adcy5	IDA		Rat	PMID:10894801|RGD:2315006
Biological Process	GO:0006171	cAMP biosynthetic process	Adcy5	IDA		Rat	PMID:11738086|RGD:2312641
Biological Process	GO:0006171	cAMP biosynthetic process	Adcy5	IDA		Rat	PMID:12711600|RGD:2312674
Biological Process	GO:1904322	cellular response to forskolin	ADCY5	IDA		Human	PMID:15385642
Biological Process	GO:1904322	cellular response to forskolin	ADCY5	IDA		Human	PMID:24700542
Biological Process	GO:0001973	G protein-coupled adenosine receptor signaling pathway	Adcy5	IGI	MGI:MGI:99402	Mouse	PMID:12223546
Biological Process	GO:0007507	heart development	Adcy5	IEP		Rat	PMID:19734365|RGD:13464133
Biological Process	GO:0007626	locomotory behavior	Adcy5	IMP	MGI:MGI:2662295	Mouse	PMID:12665504
Biological Process	GO:0050885	neuromuscular process controlling balance	Adcy5	IMP	MGI:MGI:2662295	Mouse	PMID:12665504
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ADCY5	IMP		Human	PMID:24740569
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	ADCY5	IMP		Human	PMID:24740569
Biological Process	GO:0001932	regulation of protein phosphorylation	adcy5	IDA		Zfish	PMID:19571131
Biological Process	GO:0045471	response to ethanol	adcy5	IMP	ZFIN:ZDB-GENO-090806-5	Zfish	PMID:19571131
Biological Process	GO:0043278	response to morphine	Adcy5	IEP		Rat	PMID:18801381|RGD:13464135

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern