Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Adcy8

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ADCY8
- Mouse genes Adcy8
- Rat genes Adcy8
- Zfish genes adcy8
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adcy8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	Adcy8	IDA		Rat	PMID:22399809\|RGD:13800539
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy8	IMP		Mouse	PMID:10799557
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy8	IGI	MGI:MGI:99677	Mouse	PMID:10482244
Molecular Function	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	Adcy8	IMP		Mouse	MGI:MGI:1860567\|PMID:10864938
Molecular Function	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	Adcy8	IDA		Rat	PMID:11856299\|RGD:13800543
Molecular Function	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	Adcy8	IDA		Rat	PMID:13680124\|RGD:2312682
Molecular Function	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	Adcy8	IDA		Rat	PMID:19158400\|RGD:13800545
Molecular Function	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	Adcy8	IDA		Rat	PMID:8163524\|RGD:69741
Molecular Function	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	Adcy8	IDA		Rat	PMID:8557635\|RGD:13825188
Molecular Function	GO:0005516	calmodulin binding	Adcy8	IDA		Rat	PMID:16258073\|RGD:13800544
Molecular Function	GO:0005516	calmodulin binding	Adcy8	IDA		Rat	PMID:19305019\|RGD:7241269
Molecular Function	GO:0140677	molecular function activator activity	Adcy8	IMP		Mouse	PMID:10799557
Molecular Function	GO:0140678	molecular function inhibitor activity	Adcy8	IMP		Mouse	PMID:10799557
Molecular Function	GO:0019902	phosphatase binding	Adcy8	IPI	UniProtKB:P63330	Rat	PMID:16258073\|RGD:13800544
Molecular Function	GO:0019902	phosphatase binding	Adcy8	IPI	UniProtKB:P67775	Rat	PMID:16258073\|RGD:13800544
Molecular Function	GO:0019902	phosphatase binding	Adcy8	IPI	UniProtKB:Q76MZ3	Rat	PMID:16258073\|RGD:13800544
Molecular Function	GO:0005515	protein binding	Adcy8	IPI	UniProtKB:D3YVF0	Mouse	MGI:MGI:6214755\|PMID:20410303
Molecular Function	GO:0005515	protein binding	Adcy8	IPI	UniProtKB:P24587\|UniProtKB:P24588	Rat	PMID:20410303\|RGD:7242424
Molecular Function	GO:0005515	protein binding	Adcy8	IPI	RGD:1345297	Rat	PMID:21771783\|RGD:7349313
Molecular Function	GO:0005515	protein binding	Adcy8	IPI	UniProtKB:P24588	Rat	PMID:21771783\|RGD:7349313
Molecular Function	GO:0005515	protein binding	Adcy8	IPI	UniProtKB:Q13586	Rat	PMID:22494970\|RGD:13800546
Molecular Function	GO:0005515	protein binding	Adcy8	IPI	UniProtKB:Q96D31	Rat	PMID:22494970\|RGD:13800546
Molecular Function	GO:0005515	protein binding	Adcy8	IPI	UniProtKB:P13861\|UniProtKB:P24588	Rat	PMID:22976297\|RGD:13800547
Molecular Function	GO:0005515	protein binding	Adcy8	IPI	UniProtKB:Q14738	Rat	PMID:22976297\|RGD:13800547
Molecular Function	GO:0046983	protein dimerization activity	Adcy8	IDA		Rat	PMID:19158400\|RGD:13800545
Molecular Function	GO:0046982	protein heterodimerization activity	Adcy8	IMP		Rat	PMID:11856299\|RGD:13800543
Molecular Function	GO:0042803	protein homodimerization activity	Adcy8	IDA		Rat	PMID:11856299\|RGD:13800543
Molecular Function	GO:0042803	protein homodimerization activity	Adcy8	IDA		Rat	PMID:19158400\|RGD:13800545
Molecular Function	GO:0051721	protein phosphatase 2A binding	Adcy8	IDA		Rat	PMID:22976297\|RGD:13800547
Cellular Component	GO:0015629	actin cytoskeleton	Adcy8	IDA		Rat	PMID:22399809\|RGD:13800539
Cellular Component	GO:0016324	apical plasma membrane	Adcy8	IDA		Mouse	MGI:MGI:2679807\|PMID:14585998
Cellular Component	GO:0030424	axon	Adcy8	IDA		Mouse	MGI:MGI:2679807\|PMID:14585998
Cellular Component	GO:0016323	basolateral plasma membrane	Adcy8	IDA		Mouse	MGI:MGI:2679807\|PMID:14585998
Cellular Component	GO:0005901	caveola	Adcy8	IDA		Rat	PMID:11744699\|RGD:13800535
Cellular Component	GO:0005905	clathrin-coated pit	Adcy8	IDA		Rat	PMID:19158400\|RGD:13800545
Cellular Component	GO:0030425	dendrite	Adcy8	IDA		Mouse	MGI:MGI:2679807\|PMID:14585998
Cellular Component	GO:0030425	dendrite	Adcy8	IDA		Mouse	MGI:MGI:3712989\|PMID:17335981
Cellular Component	GO:0030425	dendrite	Adcy8	IDA		Rat	PMID:16258073\|RGD:13800544
Cellular Component	GO:0060076	excitatory synapse	Adcy8	IDA		Mouse	MGI:MGI:2679807\|PMID:14585998
Cellular Component	GO:0098978	glutamatergic synapse	Adcy8	IMP		Mouse	PMID:14585998
Cellular Component	GO:0098978	glutamatergic synapse	Adcy8	IDA		Mouse	PMID:14585998
Cellular Component	GO:0098978	glutamatergic synapse	Adcy8	IDA		Mouse	PMID:10482244
Cellular Component	GO:0098978	glutamatergic synapse	Adcy8	IMP		Mouse	PMID:10482244
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Adcy8	IDA		Mouse	PMID:14585998
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Adcy8	IMP		Mouse	PMID:14585998
Cellular Component	GO:0016020	membrane	Adcy8	IDA		Rat	PMID:13680124\|RGD:2312682
Cellular Component	GO:0045121	membrane raft	Adcy8	IDA		Rat	PMID:16258073\|RGD:13800544
Cellular Component	GO:0045121	membrane raft	Adcy8	IDA		Rat	PMID:19158400\|RGD:13800545
Cellular Component	GO:0045121	membrane raft	Adcy8	IDA		Rat	PMID:22494970\|RGD:13800546
Cellular Component	GO:0032809	neuronal cell body membrane	Adcy8	IDA		Mouse	MGI:MGI:2679807\|PMID:14585998
Cellular Component	GO:0032809	neuronal cell body membrane	Adcy8	IDA		Rat	PMID:16258073\|RGD:13800544
Cellular Component	GO:0005886	plasma membrane	Adcy8	IDA		Mouse	PMID:23292513
Cellular Component	GO:0005886	plasma membrane	Adcy8	IDA		Rat	PMID:13680124\|RGD:2312682
Cellular Component	GO:0005886	plasma membrane	Adcy8	IDA		Rat	PMID:19171672\|RGD:13800548
Cellular Component	GO:0005886	plasma membrane	Adcy8	IDA		Rat	PMID:21046358\|RGD:8553299
Cellular Component	GO:0005886	plasma membrane	Adcy8	IDA		Rat	PMID:21771783\|RGD:7349313
Cellular Component	GO:0044853	plasma membrane raft	Adcy8	IDA		Rat	PMID:19171672\|RGD:13800548
Cellular Component	GO:0014069	postsynaptic density	Adcy8	IDA		Mouse	MGI:MGI:3712989\|PMID:17335981
Cellular Component	GO:0048786	presynaptic active zone	Adcy8	IDA		Mouse	MGI:MGI:3712989\|PMID:17335981
Cellular Component	GO:0048786	presynaptic active zone	Adcy8	IDA		Mouse	MGI:MGI:3790159\|PMID:18448650
Cellular Component	GO:0042734	presynaptic membrane	Adcy8	IEP		Mouse	PMID:17335981
Cellular Component	GO:0042734	presynaptic membrane	Adcy8	IDA		Mouse	PMID:17335981
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Adcy8	IDA		Mouse	PMID:10482244
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Adcy8	IMP		Mouse	PMID:10482244
Biological Process	GO:0034199	activation of protein kinase A activity	Adcy8	IMP		Rat	PMID:25381556\|RGD:13825194
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Adcy8	IMP	MGI:MGI:2176596	Mouse	PMID:25403481
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Adcy8	IDA		Mouse	PMID:9075801
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Adcy8	IMP		Rat	PMID:21046358\|RGD:8553299
Biological Process	GO:0016199	axon midline choice point recognition	adcy8	IGI	ZFIN:ZDB-GENO-070412-5,ZFIN:ZDB-MRPHLNO-100622-1,ZFIN:ZDB-MRPHLNO-100622-2	Zfish	PMID:20505109
Biological Process	GO:0016199	axon midline choice point recognition	adcy8	IMP	ZFIN:ZDB-MRPHLNO-100622-1,ZFIN:ZDB-MRPHLNO-100622-2	Zfish	PMID:20505109
Biological Process	GO:0016199	axon midline choice point recognition	adcy8	IGI	ZFIN:ZDB-MRPHLNO-100622-1,ZFIN:ZDB-MRPHLNO-100622-2,ZFIN:ZDB-MRPHLNO-100805-5,ZFIN:ZDB-MRPHLNO-100805-6	Zfish	PMID:20505109
Biological Process	GO:0016199	axon midline choice point recognition	adcy8	IGI	ZFIN:ZDB-GENO-070412-4,ZFIN:ZDB-MRPHLNO-100622-1,ZFIN:ZDB-MRPHLNO-100622-2	Zfish	PMID:20505109
Biological Process	GO:0006171	cAMP biosynthetic process	Adcy8	IMP		Rat	PMID:16741924\|RGD:2312769
Biological Process	GO:0006171	cAMP biosynthetic process	Adcy8	IMP		Rat	PMID:19305019\|RGD:7241269
Biological Process	GO:0006171	cAMP biosynthetic process	Adcy8	IMP		Rat	PMID:19444869\|RGD:2312785
Biological Process	GO:0019933	cAMP-mediated signaling	Adcy8	IDA		Rat	PMID:8163524\|RGD:69741
Biological Process	GO:0071277	cellular response to calcium ion	Adcy8	IDA		Rat	PMID:19158400\|RGD:13800545
Biological Process	GO:0071277	cellular response to calcium ion	Adcy8	IMP		Rat	PMID:19305019\|RGD:7241269
Biological Process	GO:0071277	cellular response to calcium ion	Adcy8	IDA		Rat	PMID:20410303\|RGD:7242424
Biological Process	GO:1904322	cellular response to forskolin	Adcy8	IDA		Rat	PMID:13680124\|RGD:2312682
Biological Process	GO:0071377	cellular response to glucagon stimulus	Adcy8	IDA		Mouse	PMID:23292513
Biological Process	GO:0071377	cellular response to glucagon stimulus	Adcy8	IMP		Rat	PMID:21046358\|RGD:8553299
Biological Process	GO:0071333	cellular response to glucose stimulus	Adcy8	IDA		Rat	PMID:21046358\|RGD:8553299
Biological Process	GO:0071315	cellular response to morphine	Adcy8	IMP		Mouse	MGI:MGI:3808962\|PMID:18222416
Biological Process	GO:0071315	cellular response to morphine	Adcy8	IDA		Rat	PMID:16186630\|RGD:13825193
Biological Process	GO:0038003	G protein-coupled opioid receptor signaling pathway	Adcy8	IDA		Rat	PMID:16186630\|RGD:13825193
Biological Process	GO:0042593	glucose homeostasis	Adcy8	IMP		Mouse	MGI:MGI:5636119\|PMID:25403481
Biological Process	GO:0010255	glucose mediated signaling pathway	Adcy8	IMP		Mouse	MGI:MGI:5636119\|PMID:25403481
Biological Process	GO:0010255	glucose mediated signaling pathway	Adcy8	IDA		Rat	PMID:13680124\|RGD:2312682
Biological Process	GO:0007626	locomotory behavior	Adcy8	IMP		Mouse	MGI:MGI:3808962\|PMID:18222416
Biological Process	GO:0007616	long-term memory	Adcy8	IGI	MGI:MGI:99677	Mouse	PMID:10482244
Biological Process	GO:0007613	memory	Adcy8	IMP		Mouse	MGI:MGI:3790159\|PMID:18448650
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Adcy8	IDA		Mouse	PMID:14585998
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Adcy8	IMP		Mouse	PMID:14585998
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Adcy8	IMP		Mouse	PMID:10482244
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Adcy8	IDA		Mouse	PMID:10482244
Biological Process	GO:0150076	neuroinflammatory response	Adcy8	IMP		Mouse	MGI:MGI:3621665\|PMID:12441059
Biological Process	GO:0032793	positive regulation of CREB transcription factor activity	Adcy8	IMP		Mouse	MGI:MGI:1860567\|PMID:10864938
Biological Process	GO:0032793	positive regulation of CREB transcription factor activity	Adcy8	IMP		Mouse	MGI:MGI:3621665\|PMID:12441059
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Adcy8	IMP		Rat	PMID:21046358\|RGD:8553299
Biological Process	GO:0032024	positive regulation of insulin secretion	Adcy8	IMP	MGI:MGI:2176596	Mouse	PMID:25403481
Biological Process	GO:0032024	positive regulation of insulin secretion	Adcy8	IDA		Mouse	PMID:9075801
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Adcy8	IMP		Mouse	MGI:MGI:5636119\|PMID:25403481
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Adcy8	IMP		Rat	PMID:21046358\|RGD:8553299
Biological Process	GO:1900454	positive regulation of long-term synaptic depression	Adcy8	IMP		Mouse	MGI:MGI:1860567\|PMID:10864938
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	Adcy8	IMP		Mouse	MGI:MGI:1344240\|PMID:10482244
Biological Process	GO:0031915	positive regulation of synaptic plasticity	Adcy8	IMP		Mouse	MGI:MGI:2679807\|PMID:14585998
Biological Process	GO:0051259	protein complex oligomerization	Adcy8	IDA		Rat	PMID:19158400\|RGD:13800545
Biological Process	GO:0051260	protein homooligomerization	Adcy8	IMP		Rat	PMID:11856299\|RGD:13800543
Biological Process	GO:0080135	regulation of cellular response to stress	Adcy8	IMP		Mouse	MGI:MGI:6210167\|PMID:27234425
Biological Process	GO:0080135	regulation of cellular response to stress	Adcy8	IMP		Mouse	MGI:MGI:3765127\|PMID:12206999
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	Adcy8	IMP		Mouse	MGI:MGI:5636119\|PMID:25403481
Biological Process	GO:0031290	retinal ganglion cell axon guidance	adcy8	IGI	ZFIN:ZDB-MRPHLNO-100622-1,ZFIN:ZDB-MRPHLNO-100622-2,ZFIN:ZDB-MRPHLNO-100805-5,ZFIN:ZDB-MRPHLNO-100805-6	Zfish	PMID:20505109
Biological Process	GO:0031290	retinal ganglion cell axon guidance	adcy8	IMP	ZFIN:ZDB-MRPHLNO-100622-1,ZFIN:ZDB-MRPHLNO-100622-2	Zfish	PMID:20505109
Biological Process	GO:0031290	retinal ganglion cell axon guidance	adcy8	IGI	ZFIN:ZDB-GENO-070412-4,ZFIN:ZDB-MRPHLNO-100622-1,ZFIN:ZDB-MRPHLNO-100622-2	Zfish	PMID:20505109
Biological Process	GO:0031290	retinal ganglion cell axon guidance	adcy8	IGI	ZFIN:ZDB-GENO-070412-5,ZFIN:ZDB-MRPHLNO-100622-1,ZFIN:ZDB-MRPHLNO-100622-2	Zfish	PMID:20505109

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.