Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ADD1
  • Mouse genes Add1
  • Rat genes Add1
  • Zfish genes add1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Add1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	ADD1	IDA		Human	PMID:7642559
Molecular Function	GO:0045296	cadherin binding	ADD1	HDA		Human	PMID:25468996
Molecular Function	GO:0005515	protein binding	ADD1	IPI	UniProtKB:P02489	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ADD1	IPI	UniProtKB:Q13153	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Add1	IPI	RGD:2043	Rat	PMID:7592723|RGD:631726
Molecular Function	GO:0046982	protein heterodimerization activity	ADD1	IPI	UniProtKB:P35612	Human	PMID:7642559
Molecular Function	GO:0042803	protein homodimerization activity	ADD1	IPI	UniProtKB:P35611	Human	PMID:7642559
Molecular Function	GO:0003723	RNA binding	ADD1	HDA		Human	PMID:22658674
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ADD1	IPI	UniProtKB:P22670	Human	PMID:16289097
Molecular Function	GO:0030507	spectrin binding	ADD1	IDA		Human	PMID:7642559
Molecular Function	GO:0005200	structural constituent of cytoskeleton	Add1	IDA		Mouse	PMID:10485892
Molecular Function	GO:0042608	T cell receptor binding	Add1	IDA		Rat	PMID:15163540|RGD:1624956
Cellular Component	GO:0005912	adherens junction	ADD1	IDA		Human	PMID:25978380
Cellular Component	GO:0005912	adherens junction	Add1	IMP		Mouse	MGI:MGI:5796260|PMID:25978380
Cellular Component	GO:0005737	cytoplasm	ADD1	IDA		Human	PMID:25978380
Cellular Component	GO:0005856	cytoskeleton	Add1	IDA		Mouse	PMID:10485892
Cellular Component	GO:0030425	dendrite	Add1	IDA		Rat	PMID:8624703|RGD:1624954
Cellular Component	GO:0043197	dendritic spine	Add1	IDA		Rat	PMID:8624703|RGD:1624954
Cellular Component	GO:0008290	F-actin capping protein complex	ADD1	IDA		Human	PMID:8626479
Cellular Component	GO:0005925	focal adhesion	ADD1	HDA		Human	PMID:21423176
Cellular Component	GO:0016020	membrane	Add1	IDA		Mouse	PMID:10485892
Cellular Component	GO:0016604	nuclear body	ADD1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	ADD1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ADD1	IDA		Human	PMID:16289097
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Add1	IDA		Rat	PMID:20493242|RGD:5148002
Cellular Component	GO:0005886	plasma membrane	ADD1	IDA		Human	PMID:25978380
Cellular Component	GO:0005886	plasma membrane	ADD1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Add1	IMP		Mouse	MGI:MGI:5796260|PMID:25978380
Cellular Component	GO:0014069	postsynaptic density	Add1	IDA		Rat	PMID:11226670|RGD:5147998
Cellular Component	GO:0045202	synapse	Add1	IDA		Rat	PMID:8624703|RGD:1624954
Biological Process	GO:0051017	actin filament bundle assembly	ADD1	IDA		Human	PMID:3693401
Biological Process	GO:0051016	barbed-end actin filament capping	ADD1	IDA		Human	PMID:8626479
Biological Process	GO:0000902	cell morphogenesis	Add1	IMP	MGI:MGI:3799499	Mouse	PMID:18723693
Biological Process	GO:0006884	cell volume homeostasis	Add1	IMP	MGI:MGI:3799499	Mouse	PMID:18723693
Biological Process	GO:0071277	cellular response to calcium ion	ADD1	IDA		Human	PMID:25978380
Biological Process	GO:0071277	cellular response to calcium ion	Add1	IDA		Mouse	MGI:MGI:5796260|PMID:25978380
Biological Process	GO:0071300	cellular response to retinoic acid	Add1	IDA		Rat	PMID:20493242|RGD:5148002
Biological Process	GO:0030218	erythrocyte differentiation	Add1	IMP	MGI:MGI:3799499	Mouse	PMID:18723693
Biological Process	GO:0020027	hemoglobin metabolic process	Add1	IMP	MGI:MGI:3799499	Mouse	PMID:18723693
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	Add1	IMP	MGI:MGI:3799499	Mouse	PMID:18723693
Biological Process	GO:0001701	in utero embryonic development	Add1	IMP	MGI:MGI:3799499	Mouse	PMID:18723693
Biological Process	GO:0035264	multicellular organism growth	Add1	IMP	MGI:MGI:3799499	Mouse	PMID:18723693
Biological Process	GO:0030837	negative regulation of actin filament polymerization	Add1	IMP		Rat	PMID:8675693|RGD:7174724
Biological Process	GO:1903393	positive regulation of adherens junction organization	ADD1	IDA		Human	PMID:25978380
Biological Process	GO:1903393	positive regulation of adherens junction organization	Add1	IMP		Mouse	MGI:MGI:5796260|PMID:25978380
Biological Process	GO:0045766	positive regulation of angiogenesis	Add1	IDA		Rat	PMID:17512505|RGD:5148005
Biological Process	GO:0045807	positive regulation of endocytosis	Add1	IMP		Rat	PMID:18524856|RGD:5148004
Biological Process	GO:1903142	positive regulation of establishment of endothelial barrier	ADD1	IDA		Human	PMID:25978380
Biological Process	GO:1903142	positive regulation of establishment of endothelial barrier	Add1	IMP		Mouse	MGI:MGI:5796260|PMID:25978380
Biological Process	GO:0032092	positive regulation of protein binding	ADD1	IDA		Human	PMID:3693401
Biological Process	GO:0032092	positive regulation of protein binding	ADD1	IDA		Human	PMID:7642559

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern