Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ADD2
  • Mouse genes Add2
  • Rat genes Add2
  • Zfish genes add2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Add2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	ADD2	IMP		Human	PMID:25425738
Molecular Function	GO:0051015	actin filament binding	ADD2	IDA		Human	PMID:7642559
Molecular Function	GO:0060090	molecular adaptor activity	ADD2	EXP		Human	PMID:7642559
Molecular Function	GO:0060090	molecular adaptor activity	ADD2	IDA		Human	PMID:7642559
Molecular Function	GO:0046982	protein heterodimerization activity	ADD2	IPI	UniProtKB:P35611	Human	PMID:7642559
Molecular Function	GO:0042803	protein homodimerization activity	ADD2	IPI	UniProtKB:P35612	Human	PMID:7642559
Molecular Function	GO:0019901	protein kinase binding	ADD2	IPI	UniProtKB:P12931	Human	PMID:25425738
Molecular Function	GO:0030507	spectrin binding	ADD2	IDA		Human	PMID:7642559
Molecular Function	GO:0005200	structural constituent of cytoskeleton	Add2	IDA		Mouse	PMID:10485892
Cellular Component	GO:0031410	cytoplasmic vesicle	ADD2	IDA		Human	PMID:18347014
Cellular Component	GO:0008290	F-actin capping protein complex	ADD2	IDA		Human	PMID:8626479
Cellular Component	GO:0098978	glutamatergic synapse	Add2	IDA		Rat	PMID:9679146|RGD:13702217
Cellular Component	GO:0016020	membrane	Add2	IDA		Mouse	PMID:10485892
Cellular Component	GO:0044853	plasma membrane raft	ADD2	IMP		Human	PMID:25425738
Cellular Component	GO:0098794	postsynapse	Add2	IDA		Rat	PMID:9679146|RGD:13702217
Cellular Component	GO:0014069	postsynaptic density	Add2	IDA		Mouse	PMID:17114649
Biological Process	GO:0051017	actin filament bundle assembly	ADD2	IDA		Human	PMID:3693401
Biological Process	GO:0051016	barbed-end actin filament capping	ADD2	IDA		Human	PMID:8626479
Biological Process	GO:0030097	hemopoiesis	Add2	IMP	MGI:MGI:2149065	Mouse	PMID:10485892
Biological Process	GO:0050900	leukocyte migration	ADD2	IMP		Human	PMID:25425738
Biological Process	GO:0050901	leukocyte tethering or rolling	ADD2	IMP		Human	PMID:25425738
Biological Process	GO:0006811	monoatomic ion transport	Add2	IMP		Rat	PMID:2059221|RGD:631712
Biological Process	GO:0032092	positive regulation of protein binding	ADD2	IDA		Human	PMID:3693401
Biological Process	GO:0032092	positive regulation of protein binding	ADD2	IDA		Human	PMID:7642559
Biological Process	GO:0065003	protein-containing complex assembly	ADD2	IDA		Human	PMID:18347014
Biological Process	GO:0007416	synapse assembly	Add2	IMP		Mouse	PMID:21435558
Biological Process	GO:0007416	synapse assembly	Add2	IDA		Mouse	PMID:21435558
Biological Process	GO:0007416	synapse assembly	Add2	IEP		Mouse	PMID:21435558

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern