Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ADGRA2
  • Mouse genes Adgra2
  • Rat genes Adgra2
  • Zfish genes adgra2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adgra2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	ADGRA2	IPI	UniProtKB:Q12959	Human	PMID:15021905
Molecular Function	GO:0005515	protein binding	ADGRA2	IPI	UniProtKB:Q12959-2	Human	PMID:15021905
Molecular Function	GO:0005515	protein binding	ADGRA2	IPI	UniProtKB:Q12959	Human	PMID:24550280
Cellular Component	GO:0009986	cell surface	Adgra2	IDA		Mouse	PMID:21421844
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ADGRA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ADGRA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Adgra2	IDA		Mouse	MGI:MGI:6114565|PMID:28803732
Cellular Component	GO:0005886	plasma membrane	adgra2	IDA		Zfish	PMID:27979830|ZFIN:ZDB-PUB-161217-10
Cellular Component	GO:1990909	Wnt signalosome	ADGRA2	IDA		Human	PMID:30026314
Cellular Component	GO:1990909	Wnt signalosome	adgra2	IDA		Zfish	PMID:30026314|ZFIN:ZDB-PUB-180907-1
Biological Process	GO:0001525	angiogenesis	Adgra2	IMP	MGI:MGI:4949903	Mouse	PMID:21421844
Biological Process	GO:0007417	central nervous system development	Adgra2	IMP		Mouse	MGI:MGI:4839817|PMID:21071672
Biological Process	GO:0022009	central nervous system vasculogenesis	adgra2	IMP	ZFIN:ZDB-GENO-170929-16	Zfish	PMID:28365243
Biological Process	GO:1990791	dorsal root ganglion development	adgra2	IMP	ZFIN:ZDB-MRPHLNO-150904-2	Zfish	PMID:26051822
Biological Process	GO:1990791	dorsal root ganglion development	adgra2	IMP	ZFIN:ZDB-GENO-170306-19	Zfish	PMID:27979884
Biological Process	GO:1990791	dorsal root ganglion development	adgra2	IMP	ZFIN:ZDB-GENO-151020-1	Zfish	PMID:27979884
Biological Process	GO:1990791	dorsal root ganglion development	adgra2	IMP	ZFIN:ZDB-GENO-170306-19	Zfish	PMID:24004948
Biological Process	GO:1990791	dorsal root ganglion development	adgra2	IMP	ZFIN:ZDB-GENO-151020-1	Zfish	PMID:26051822
Biological Process	GO:1990791	dorsal root ganglion development	adgra2	IMP	ZFIN:ZDB-MRPHLNO-150904-2	Zfish	PMID:27979884
Biological Process	GO:0043542	endothelial cell migration	Adgra2	IMP		Mouse	MGI:MGI:4839817|PMID:21071672
Biological Process	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	Adgra2	IMP	MGI:MGI:4949903	Mouse	PMID:21421844
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	ADGRA2	IDA		Human	PMID:30026314
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Adgra2	IDA		Mouse	MGI:MGI:6114565|PMID:28803732
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	adgra2	IDA		Zfish	PMID:30026314|ZFIN:ZDB-PUB-180907-1
Biological Process	GO:0010595	positive regulation of endothelial cell migration	Adgra2	IDA		Mouse	PMID:21421844
Biological Process	GO:0045765	regulation of angiogenesis	Adgra2	IMP		Mouse	MGI:MGI:4839817|PMID:21071672
Biological Process	GO:0050920	regulation of chemotaxis	Adgra2	IMP		Mouse	MGI:MGI:4839817|PMID:21071672
Biological Process	GO:0090210	regulation of establishment of blood-brain barrier	Adgra2	IMP		Mouse	MGI:MGI:6102983|PMID:28288111
Biological Process	GO:0090210	regulation of establishment of blood-brain barrier	Adgra2	IMP	MGI:MGI:4949903	Mouse	PMID:21421844
Biological Process	GO:0002040	sprouting angiogenesis	Adgra2	IMP		Mouse	MGI:MGI:4839817|PMID:21071672
Biological Process	GO:0002040	sprouting angiogenesis	Adgra2	IMP	MGI:MGI:5544776	Mouse	PMID:23918385
Biological Process	GO:0002040	sprouting angiogenesis	adgra2	IMP	ZFIN:ZDB-GENO-151020-1	Zfish	PMID:26051822
Biological Process	GO:0001944	vasculature development	adgra2	IMP	ZFIN:ZDB-GENO-151020-1	Zfish	PMID:27979884
Biological Process	GO:0001944	vasculature development	adgra2	IMP	ZFIN:ZDB-MRPHLNO-150904-2	Zfish	PMID:26051822
Biological Process	GO:0001944	vasculature development	adgra2	IMP	ZFIN:ZDB-MRPHLNO-150904-2	Zfish	PMID:27979884
Biological Process	GO:0001944	vasculature development	adgra2	IMP	ZFIN:ZDB-GENO-170306-19	Zfish	PMID:27979884
Biological Process	GO:0001944	vasculature development	adgra2	IMP	ZFIN:ZDB-GENO-151020-1	Zfish	PMID:26051822
Biological Process	GO:0016055	Wnt signaling pathway	adgra2	IMP	ZFIN:ZDB-MRPHLNO-150904-2	Zfish	PMID:26051822

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern