Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ADH1A,ADH1B,ADH1C
  • Mouse genes Adh1
  • Rat genes Adh1
  • Zfish genes adh5l,adh8a,adh8b,zgc:77938
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adh1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004022	alcohol dehydrogenase (NAD+) activity	ADH1C	IDA		Human	PMID:6391957
Molecular Function	GO:0004022	alcohol dehydrogenase (NAD+) activity	ADH1A	IDA		Human	PMID:2738060
Molecular Function	GO:0004022	alcohol dehydrogenase (NAD+) activity	Adh1	IDA		Mouse	PMID:6816803
Molecular Function	GO:0004022	alcohol dehydrogenase (NAD+) activity	Adh1	IDA		Mouse	PMID:6370228
Molecular Function	GO:0004022	alcohol dehydrogenase (NAD+) activity	Adh1	IDA		Mouse	PMID:518534
Molecular Function	GO:0004022	alcohol dehydrogenase (NAD+) activity	Adh1	IDA		Mouse	PMID:3996732
Molecular Function	GO:0004022	alcohol dehydrogenase (NAD+) activity	Adh1	IDA		Mouse	PMID:7026729
Molecular Function	GO:0004022	alcohol dehydrogenase (NAD+) activity	Adh1	IDA		Rat	PMID:10094961|RGD:1642948
Molecular Function	GO:0004022	alcohol dehydrogenase (NAD+) activity	Adh1	IDA		Rat	PMID:1558299|RGD:1642949
Molecular Function	GO:0004022	alcohol dehydrogenase (NAD+) activity	adh8b	IDA		Zfish	PMID:15231826
Molecular Function	GO:0004022	alcohol dehydrogenase (NAD+) activity	adh8a	IDA		Zfish	PMID:15231826
Molecular Function	GO:0004024	alcohol dehydrogenase activity, zinc-dependent	ADH1B	IDA		Human	PMID:9982
Molecular Function	GO:0004024	alcohol dehydrogenase activity, zinc-dependent	ADH1A	IDA		Human	PMID:9982
Molecular Function	GO:0035276	ethanol binding	Adh1	IDA		Rat	PMID:10094961|RGD:1642948
Molecular Function	GO:0035276	ethanol binding	Adh1	IDA		Rat	PMID:1558299|RGD:1642949
Molecular Function	GO:0018467	formaldehyde dehydrogenase activity	adh8b	IDA		Zfish	PMID:15231826
Molecular Function	GO:0042802	identical protein binding	Adh1	IPI	PR:P00329	Mouse	PMID:3996732
Molecular Function	GO:0051287	NAD binding	Adh1	IDA		Rat	PMID:10094961|RGD:1642948
Molecular Function	GO:0051287	NAD binding	Adh1	IDA		Rat	PMID:1558299|RGD:1642949
Molecular Function	GO:0004745	NAD-retinol dehydrogenase activity	ADH1B	IDA		Human	PMID:15369820
Molecular Function	GO:0004745	NAD-retinol dehydrogenase activity	Adh1	IDA		Rat	PMID:2940107|RGD:2315740
Molecular Function	GO:0097159	organic cyclic compound binding	Adh1	IPI	CHEBI:28032|CHEBI:46195	Rat	PMID:16385241|RGD:1642947
Molecular Function	GO:0005515	protein binding	ADH1A	IPI	UniProtKB:P23769	Human	PMID:16153155
Molecular Function	GO:0008270	zinc ion binding	ADH1B	IDA		Human	PMID:9982
Cellular Component	GO:0005829	cytosol	ADH1B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	ADH1C	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	ADH1A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Adh1	IDA		Rat	PMID:16385241|RGD:1642947
Cellular Component	GO:0005622	intracellular anatomical structure	Adh1	IDA		Mouse	PMID:9002638
Cellular Component	GO:0005739	mitochondrion	Adh1	IDA		Mouse	PMID:3996732
Cellular Component	GO:0005654	nucleoplasm	ADH1B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	ADH1C	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	ADH1A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ADH1B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ADH1C	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ADH1A	IDA		Human	GO_REF:0000052
Biological Process	GO:0046186	acetaldehyde biosynthetic process	Adh1	IDA		Rat	PMID:10094961|RGD:1642948
Biological Process	GO:0006066	alcohol metabolic process	ADH1A	IDA		Human	PMID:2738060
Biological Process	GO:0006066	alcohol metabolic process	adh8b	IDA		Zfish	PMID:15231826
Biological Process	GO:0006066	alcohol metabolic process	adh8a	IDA		Zfish	PMID:15231826
Biological Process	GO:0031100	animal organ regeneration	Adh1	IEP		Rat	PMID:17126819|RGD:2315739
Biological Process	GO:0048149	behavioral response to ethanol	Adh1	IMP	MGI:MGI:2180100	Mouse	PMID:10358022
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	adh8a	IDA		Zfish	PMID:18618001
Biological Process	GO:0006068	ethanol catabolic process	Adh1	IDA		Mouse	PMID:518534
Biological Process	GO:0006068	ethanol catabolic process	Adh1	IMP	MGI:MGI:2180100	Mouse	PMID:10358022
Biological Process	GO:0006067	ethanol metabolic process	adh8a	IDA		Zfish	PMID:15231826
Biological Process	GO:0006069	ethanol oxidation	ADH1B	IDA		Human	PMID:2398055
Biological Process	GO:0006069	ethanol oxidation	ADH1C	IDA		Human	PMID:6391957
Biological Process	GO:0006069	ethanol oxidation	Adh1	IDA		Rat	PMID:10094961|RGD:1642948
Biological Process	GO:0006069	ethanol oxidation	Adh1	IDA		Rat	PMID:1558299|RGD:1642949
Biological Process	GO:0046292	formaldehyde metabolic process	adh8b	IDA		Zfish	PMID:15231826
Biological Process	GO:0006070	octanol metabolic process	adh8b	IDA		Zfish	PMID:15231826
Biological Process	GO:0032570	response to progesterone	Adh1	IEP		Rat	PMID:18219182|RGD:2315738
Biological Process	GO:0032526	response to retinoic acid	Adh1	IDA		Mouse	PMID:7748347
Biological Process	GO:0048545	response to steroid hormone	Adh1	IDA		Mouse	PMID:8119157
Biological Process	GO:0033574	response to testosterone	Adh1	IDA		Mouse	PMID:8973327
Biological Process	GO:0042573	retinoic acid metabolic process	Adh1	IMP	MGI:MGI:2180100	Mouse	PMID:10358022
Biological Process	GO:0042573	retinoic acid metabolic process	Adh1	IMP	MGI:MGI:2180099	Mouse	PMID:15193143
Biological Process	GO:0042573	retinoic acid metabolic process	Adh1	IMP	MGI:MGI:2180100	Mouse	PMID:12851412
Biological Process	GO:0042573	retinoic acid metabolic process	Adh1	IGI	MGI:MGI:97876	Mouse	PMID:15193143
Biological Process	GO:0001523	retinoid metabolic process	ADH1B	IDA		Human	PMID:15369820
Biological Process	GO:0001523	retinoid metabolic process	ADH1B	IDA		Human	PMID:16787387
Biological Process	GO:0001523	retinoid metabolic process	Adh1	IMP	MGI:MGI:2180100	Mouse	PMID:12027900
Biological Process	GO:0042572	retinol metabolic process	Adh1	IMP	MGI:MGI:2180100	Mouse	PMID:10358022
Biological Process	GO:0042572	retinol metabolic process	Adh1	IGI	MGI:MGI:97876	Mouse	PMID:15193143
Biological Process	GO:0042572	retinol metabolic process	Adh1	IMP	MGI:MGI:2180100	Mouse	PMID:12851412
Biological Process	GO:0042572	retinol metabolic process	Adh1	IMP	MGI:MGI:2180099	Mouse	PMID:15193143

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern