Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Adora1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ADORA1
- Mouse genes Adora1
- Rat genes Adora1
- Zfish genes adora1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adora1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	Adora1	IDA		Rat	PMID:9261808\|RGD:631744
Molecular Function	GO:0001664	G protein-coupled receptor binding	Adora1	IPI	UniProtKB:P41232	Rat	PMID:11390975\|RGD:8553380
Molecular Function	GO:0001664	G protein-coupled receptor binding	Adora1	IPI	UniProtKB:P49651	Rat	PMID:11390975\|RGD:8553380
Molecular Function	GO:0001664	G protein-coupled receptor binding	Adora1	IPI	UniProtKB:P49651	Rat	PMID:12417330\|RGD:8554816
Molecular Function	GO:0031683	G-protein beta/gamma-subunit complex binding	Adora1	IDA		Rat	PMID:12764156\|RGD:1625267
Molecular Function	GO:0031072	heat shock protein binding	Adora1	IPI	RGD:621725	Rat	PMID:10866672\|RGD:10059330
Molecular Function	GO:0032795	heterotrimeric G-protein binding	Adora1	IDA		Rat	PMID:12764156\|RGD:1625267
Molecular Function	GO:0005515	protein binding	ADORA1	IPI	UniProtKB:P29274	Human	PMID:16481441
Molecular Function	GO:0005515	protein binding	ADORA1	IPI	UniProtKB:P07550	Human	PMID:23291003
Molecular Function	GO:0005515	protein binding	ADORA1	IPI	UniProtKB:P08588	Human	PMID:23291003
Molecular Function	GO:0005515	protein binding	ADORA1	IPI	UniProtKB:P16473	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	Adora1	IPI	PR:P23818	Mouse	PMID:24259587
Molecular Function	GO:0005515	protein binding	Adora1	IPI	UniProtKB:P41232	Rat	PMID:11390975\|RGD:8553380
Molecular Function	GO:0005515	protein binding	Adora1	IPI	RGD:69247\|RGD:2281	Rat	PMID:19181933\|RGD:7297041
Molecular Function	GO:0046982	protein heterodimerization activity	Adora1	IPI	UniProtKB:P49651	Rat	PMID:11390975\|RGD:8553380
Molecular Function	GO:0044877	protein-containing complex binding	Adora1	IPI	RGD:2049	Rat	PMID:16481441\|RGD:1625231
Molecular Function	GO:0001883	purine nucleoside binding	Adora1	IPI	CHEBI:16335	Rat	PMID:11906959\|RGD:1625291
Cellular Component	GO:0032279	asymmetric synapse	Adora1	IDA		Rat	PMID:16481441\|RGD:1625231
Cellular Component	GO:0030673	axolemma	Adora1	IDA		Rat	PMID:16481441\|RGD:1625231
Cellular Component	GO:0016323	basolateral plasma membrane	Adora1	IDA		Rat	PMID:15024061\|RGD:1625258
Cellular Component	GO:0044305	calyx of Held	Adora1	EXP		Rat	PMID:12963795\|RGD:13702434
Cellular Component	GO:0044305	calyx of Held	Adora1	IDA		Rat	PMID:12963795\|RGD:13702434
Cellular Component	GO:0044297	cell body	Adora1	IDA		Rat	PMID:12417330\|RGD:8554816
Cellular Component	GO:0030425	dendrite	Adora1	IDA		Rat	PMID:12417330\|RGD:8554816
Cellular Component	GO:0030425	dendrite	Adora1	IDA		Rat	PMID:16952160\|RGD:1625217
Cellular Component	GO:0043197	dendritic spine	Adora1	IDA		Mouse	PMID:24259587
Cellular Component	GO:0012505	endomembrane system	Adora1	IDA		Rat	PMID:16952160\|RGD:1625217
Cellular Component	GO:0005783	endoplasmic reticulum	Adora1	IDA		Rat	PMID:12764156\|RGD:1625267
Cellular Component	GO:0043025	neuronal cell body	Adora1	IDA		Rat	PMID:15044554\|RGD:1625242
Cellular Component	GO:0005886	plasma membrane	ADORA1	IDA		Human	PMID:25644539
Cellular Component	GO:0005886	plasma membrane	ADORA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ADORA1	IDA		Human	PMID:27134041
Cellular Component	GO:0005886	plasma membrane	Adora1	IDA		Rat	PMID:12153486\|RGD:625619
Cellular Component	GO:0005886	plasma membrane	Adora1	IDA		Rat	PMID:16952160\|RGD:1625217
Cellular Component	GO:0014069	postsynaptic density	Adora1	IDA		Rat	PMID:14499945\|RGD:1625259
Cellular Component	GO:0045211	postsynaptic membrane	Adora1	IDA		Rat	PMID:16952160\|RGD:1625217
Cellular Component	GO:0045211	postsynaptic membrane	Adora1	IDA		Rat	PMID:16481441\|RGD:1625231
Cellular Component	GO:0048786	presynaptic active zone	Adora1	IDA		Rat	PMID:16481441\|RGD:1625231
Cellular Component	GO:0042734	presynaptic membrane	Adora1	IDA		Rat	PMID:16952160\|RGD:1625217
Cellular Component	GO:0042734	presynaptic membrane	Adora1	IDA		Rat	PMID:16481441\|RGD:1625231
Cellular Component	GO:0045202	synapse	Adora1	IDA		Mouse	PMID:24259587
Cellular Component	GO:0043195	terminal bouton	Adora1	IDA		Rat	PMID:16952160\|RGD:1625217
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	Adora1	IMP		Rat	PMID:16286581\|RGD:1625235
Biological Process	GO:0050890	cognition	Adora1	IMP		Rat	PMID:19307960\|RGD:2317919
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	Adora1	IMP		Rat	PMID:20065990\|RGD:5129094
Biological Process	GO:0060079	excitatory postsynaptic potential	Adora1	IDA		Mouse	PMID:17428973
Biological Process	GO:0060079	excitatory postsynaptic potential	Adora1	IMP		Rat	PMID:19942300\|RGD:2317911
Biological Process	GO:0055089	fatty acid homeostasis	Adora1	IDA		Rat	PMID:15220221\|RGD:1625243
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Adora1	IDA		Rat	PMID:12764156\|RGD:1625267
Biological Process	GO:0050900	leukocyte migration	Adora1	IGI	MGI:MGI:87916	Mouse	PMID:15630442
Biological Process	GO:0016042	lipid catabolic process	Adora1	IMP		Rat	PMID:19093734\|RGD:2317920
Biological Process	GO:0060292	long-term synaptic depression	Adora1	IMP		Mouse	PMID:24259587
Biological Process	GO:0060292	long-term synaptic depression	Adora1	IGI	MGI:MGI:95808	Mouse	PMID:24259587
Biological Process	GO:0070254	mucus secretion	Adora1	IGI	MGI:MGI:87916	Mouse	PMID:15630442
Biological Process	GO:0002674	negative regulation of acute inflammatory response	Adora1	IDA		Rat	PMID:2167912\|RGD:5129103
Biological Process	GO:0043066	negative regulation of apoptotic process	Adora1	IDA		Rat	PMID:12578815\|RGD:1625269
Biological Process	GO:0045776	negative regulation of blood pressure	Adora1	IMP		Rat	PMID:16690710\|RGD:5129101
Biological Process	GO:0008285	negative regulation of cell population proliferation	Adora1	IDA		Rat	PMID:12021208\|RGD:631808
Biological Process	GO:0042323	negative regulation of circadian sleep/wake cycle, non-REM sleep	Adora1	IMP		Rat	PMID:19491711\|RGD:2317916
Biological Process	GO:0042321	negative regulation of circadian sleep/wake cycle, sleep	Adora1	IDA		Rat	PMID:16109808\|RGD:1625234
Biological Process	GO:0014050	negative regulation of glutamate secretion	Adora1	IDA		Rat	PMID:16481441\|RGD:1625231
Biological Process	GO:0045822	negative regulation of heart contraction	Adora1	IMP		Rat	PMID:16286581\|RGD:1625235
Biological Process	GO:0046888	negative regulation of hormone secretion	Adora1	IMP		Rat	PMID:15044554\|RGD:1625242
Biological Process	GO:0050728	negative regulation of inflammatory response	Adora1	IGI	MGI:MGI:87916	Mouse	PMID:15630442
Biological Process	GO:0002686	negative regulation of leukocyte migration	Adora1	IGI	MGI:MGI:87916	Mouse	PMID:15630442
Biological Process	GO:0050995	negative regulation of lipid catabolic process	Adora1	IDA		Rat	PMID:15220221\|RGD:1625243
Biological Process	GO:1900453	negative regulation of long-term synaptic depression	Adora1	IGI	MGI:MGI:95808	Mouse	PMID:24259587
Biological Process	GO:1900453	negative regulation of long-term synaptic depression	Adora1	IMP		Mouse	PMID:24259587
Biological Process	GO:1900272	negative regulation of long-term synaptic potentiation	Adora1	IMP		Rat	PMID:14596853\|RGD:1625717
Biological Process	GO:0070256	negative regulation of mucus secretion	Adora1	IGI	MGI:MGI:87916	Mouse	PMID:15630442
Biological Process	GO:0032900	negative regulation of neurotrophin production	Adora1	IMP		Rat	PMID:19524026\|RGD:2317915
Biological Process	GO:0035814	negative regulation of renal sodium excretion	Adora1	IMP		Rat	PMID:14993484\|RGD:1625254
Biological Process	GO:0032229	negative regulation of synaptic transmission, GABAergic	Adora1	IMP		Rat	PMID:12626609\|RGD:1625273
Biological Process	GO:0051967	negative regulation of synaptic transmission, glutamatergic	Adora1	IDA		Rat	PMID:16481441\|RGD:1625231
Biological Process	GO:0003085	negative regulation of systemic arterial blood pressure	Adora1	IDA		Rat	PMID:9597368\|RGD:1625365
Biological Process	GO:0045777	positive regulation of blood pressure	Adora1	IDA		Rat	PMID:12234813\|RGD:631806
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	Adora1	IMP		Rat	PMID:19574994\|RGD:2317913
Biological Process	GO:0050996	positive regulation of lipid catabolic process	Adora1	IDA		Rat	PMID:9597368\|RGD:1625365
Biological Process	GO:0043410	positive regulation of MAPK cascade	Adora1	IDA		Rat	PMID:12764156\|RGD:1625267
Biological Process	GO:1901216	positive regulation of neuron death	Adora1	IDA		Rat	PMID:12151769\|RGD:1625283
Biological Process	GO:0032244	positive regulation of nucleoside transport	Adora1	IDA		Rat	PMID:15024061\|RGD:1625258
Biological Process	GO:0002793	positive regulation of peptide secretion	Adora1	IMP		Rat	PMID:16286581\|RGD:1625235
Biological Process	GO:0043268	positive regulation of potassium ion transport	Adora1	IDA		Rat	PMID:9261808\|RGD:631744
Biological Process	GO:0035307	positive regulation of protein dephosphorylation	Adora1	IDA		Rat	PMID:12234781\|RGD:1625280
Biological Process	GO:0003084	positive regulation of systemic arterial blood pressure	Adora1	IMP		Rat	PMID:8998253\|RGD:1625366
Biological Process	GO:0006612	protein targeting to membrane	Adora1	IMP		Rat	PMID:19879903\|RGD:2317912
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	Adora1	IDA		Rat	PMID:19525381\|RGD:2317914
Biological Process	GO:0055117	regulation of cardiac muscle contraction	Adora1	IMP		Rat	PMID:20334814\|RGD:2317910
Biological Process	GO:0003093	regulation of glomerular filtration	Adora1	IMP	MGI:MGI:2388340	Mouse	PMID:15283758
Biological Process	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	Adora1	EXP		Rat	PMID:12963795\|RGD:13702434
Biological Process	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	Adora1	IDA		Rat	PMID:12963795\|RGD:13702434
Biological Process	GO:0002087	regulation of respiratory gaseous exchange by nervous system process	Adora1	IMP		Rat	PMID:16352472\|RGD:1625230
Biological Process	GO:0051930	regulation of sensory perception of pain	Adora1	IMP		Mouse	MGI:MGI:3849266\|PMID:18940592
Biological Process	GO:0051930	regulation of sensory perception of pain	Adora1	IMP		Mouse	MGI:MGI:5545961\|PMID:22389722
Biological Process	GO:0060087	relaxation of vascular associated smooth muscle	Adora1	IMP		Rat	PMID:19443947\|RGD:2317917
Biological Process	GO:0001666	response to hypoxia	Adora1	IMP		Rat	PMID:16690710\|RGD:5129101
Biological Process	GO:0010035	response to inorganic substance	Adora1	IMP		Mouse	PMID:25644539
Biological Process	GO:0014074	response to purine-containing compound	ADORA1	IDA		Human	PMID:25644539
Biological Process	GO:0001659	temperature homeostasis	Adora1	IMP		Rat	PMID:16352472\|RGD:1625230
Biological Process	GO:0070328	triglyceride homeostasis	Adora1	IDA		Rat	PMID:15220221\|RGD:1625243
Biological Process	GO:0042311	vasodilation	Adora1	IDA		Rat	PMID:12100087\|RGD:1625290

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.