Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Adora2b

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ADORA2B
- Mouse genes Adora2b
- Rat genes Adora2b
- Zfish genes adora2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adora2b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	Adora2b	IMP		Mouse	PMID:16841096
Molecular Function	GO:0005515	protein binding	ADORA2B	IPI	UniProtKB:P29274	Human	PMID:29568380
Cellular Component	GO:0009986	cell surface	Adora2b	IDA		Rat	PMID:12021208\|RGD:631808
Cellular Component	GO:0098978	glutamatergic synapse	Adora2b	IDA		Mouse	PMID:25704806
Cellular Component	GO:0098978	glutamatergic synapse	Adora2b	EXP		Mouse	PMID:25704806
Cellular Component	GO:0098978	glutamatergic synapse	Adora2b	IMP		Mouse	PMID:25704806
Cellular Component	GO:0005886	plasma membrane	Adora2b	IDA		Mouse	PMID:12817016
Cellular Component	GO:0005886	plasma membrane	Adora2b	IDA		Rat	PMID:12849998\|RGD:2316131
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Adora2b	EXP		Mouse	PMID:25704806
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Adora2b	IDA		Mouse	PMID:25704806
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Adora2b	IMP		Mouse	PMID:25704806
Cellular Component	GO:0045202	synapse	Adora2b	IDA		Mouse	PMID:25704806
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Adora2b	IMP		Mouse	PMID:16841096
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Adora2b	IMP	MGI:MGI:3773754	Mouse	PMID:18340377
Biological Process	GO:0031668	cellular response to extracellular stimulus	Adora2b	IDA		Mouse	PMID:8157966
Biological Process	GO:0019934	cGMP-mediated signaling	Adora2b	IMP	MGI:MGI:3773754	Mouse	PMID:18340377
Biological Process	GO:0098508	endothelial to hematopoietic transition	adora2b	IMP	ZFIN:ZDB-MRPHLNO-150803-1	Zfish	PMID:25870200
Biological Process	GO:0043303	mast cell degranulation	Adora2b	IMP		Mouse	PMID:11454903
Biological Process	GO:0008285	negative regulation of cell population proliferation	Adora2b	IMP		Rat	PMID:11230362\|RGD:2316146
Biological Process	GO:0032966	negative regulation of collagen biosynthetic process	Adora2b	IMP		Rat	PMID:9535419\|RGD:2316149
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	Adora2b	IMP		Rat	PMID:11882603\|RGD:631750
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	Adora2b	IMP		Rat	PMID:8012696\|RGD:2316150
Biological Process	GO:0033605	positive regulation of catecholamine secretion	Adora2b	IMP		Rat	PMID:18823369\|RGD:2316113
Biological Process	GO:0008284	positive regulation of cell population proliferation	Adora2b	IMP		Rat	PMID:12021208\|RGD:631808
Biological Process	GO:0010753	positive regulation of cGMP-mediated signaling	Adora2b	IMP	MGI:MGI:3773754	Mouse	PMID:18340377
Biological Process	GO:0032722	positive regulation of chemokine production	Adora2b	IMP	MGI:MGI:3773754	Mouse	PMID:18559975
Biological Process	GO:0002882	positive regulation of chronic inflammatory response to non-antigenic stimulus	Adora2b	IMP		Mouse	PMID:16841096
Biological Process	GO:0010595	positive regulation of endothelial cell migration	Adora2b	IMP		Rat	PMID:11882603\|RGD:631750
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	Adora2b	IMP		Rat	PMID:11882603\|RGD:631750
Biological Process	GO:0031284	positive regulation of guanylate cyclase activity	Adora2b	IMP	MGI:MGI:3773754	Mouse	PMID:18340377
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Adora2b	IMP	MGI:MGI:3773754	Mouse	PMID:18559975
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Adora2b	IMP		Rat	PMID:26385692\|RGD:11533328
Biological Process	GO:0043306	positive regulation of mast cell degranulation	Adora2b	IMP		Mouse	PMID:11454903
Biological Process	GO:0010701	positive regulation of norepinephrine secretion	Adora2b	IMP		Rat	PMID:15223300\|RGD:2316128
Biological Process	GO:0010893	positive regulation of steroid biosynthetic process	Adora2b	IMP		Rat	PMID:18582595\|RGD:2316120
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	Adora2b	IMP	MGI:MGI:3773754	Mouse	PMID:18559975
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Adora2b	EXP		Mouse	PMID:25704806
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Adora2b	IDA		Mouse	PMID:25704806
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Adora2b	IMP		Mouse	PMID:25704806
Biological Process	GO:0010906	regulation of glucose metabolic process	Adora2b	IMP		Rat	PMID:26385692\|RGD:11533328
Biological Process	GO:1901532	regulation of hematopoietic progenitor cell differentiation	adora2b	IMP	ZFIN:ZDB-MRPHLNO-150803-1	Zfish	PMID:25870200
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation	adora2b	IMP	ZFIN:ZDB-MRPHLNO-150803-1	Zfish	PMID:25870200
Biological Process	GO:0060087	relaxation of vascular associated smooth muscle	Adora2b	IMP	MGI:MGI:3773754	Mouse	PMID:18340377
Biological Process	GO:1990776	response to angiotensin	Adora2b	IMP		Rat	PMID:26385692\|RGD:11533328
Biological Process	GO:0042311	vasodilation	Adora2b	IDA		Rat	PMID:10666062\|RGD:2316148

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.