Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ADORA3
  • Mouse genes Adora3
  • Rat genes Adora3
  • Zfish genes adora4a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adora3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	Adora3	IDA		Mouse	PMID:12817016
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	Adora3	IMP	MGI:MGI:2155986	Mouse	PMID:10660615
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	Adora3	IDA		Rat	PMID:1323836|RGD:631705
Cellular Component	GO:0031594	neuromuscular junction	Adora3	IDA		Mouse	PMID:24754634
Cellular Component	GO:0005886	plasma membrane	Adora3	IDA		Mouse	PMID:12817016
Cellular Component	GO:0005886	plasma membrane	Adora3	IMP	MGI:MGI:2155986	Mouse	PMID:10660615
Cellular Component	GO:0042734	presynaptic membrane	Adora3	IDA		Rat	PMID:14502093|RGD:1559305
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Adora3	EXP		Rat	PMID:8987783|RGD:13702310
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Adora3	IDA		Rat	PMID:8987783|RGD:13702310
Cellular Component	GO:0045202	synapse	Adora3	IDA		Mouse	PMID:24754634
Biological Process	GO:0019722	calcium-mediated signaling	Adora3	IMP	MGI:MGI:2155986	Mouse	PMID:12817016
Biological Process	GO:0019722	calcium-mediated signaling	Adora3	IDA		Mouse	PMID:12817016
Biological Process	GO:0001973	G protein-coupled adenosine receptor signaling pathway	Adora3	IMP		Mouse	PMID:12817016
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Adora3	IDA		Rat	PMID:12475223|RGD:631756
Biological Process	GO:0002553	histamine secretion by mast cell	Adora3	IDA		Mouse	PMID:12817016
Biological Process	GO:0002553	histamine secretion by mast cell	Adora3	IMP	MGI:MGI:2155986	Mouse	PMID:12817016
Biological Process	GO:0043303	mast cell degranulation	Adora3	IDA		Mouse	PMID:12817016
Biological Process	GO:0043303	mast cell degranulation	Adora3	IMP	MGI:MGI:2155986	Mouse	PMID:12817016
Biological Process	GO:0070254	mucus secretion	Adora3	IMP		Mouse	PMID:15240734
Biological Process	GO:0070254	mucus secretion	Adora3	IGI	MGI:MGI:87916	Mouse	PMID:15240734
Biological Process	GO:0070254	mucus secretion	Adora3	IMP	MGI:MGI:2155986	Mouse	PMID:15240734
Biological Process	GO:0030336	negative regulation of cell migration	ADORA3	IMP		Human	PMID:27886186
Biological Process	GO:0008285	negative regulation of cell population proliferation	ADORA3	IMP		Human	PMID:27886186
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ADORA3	IMP		Human	PMID:27886186
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	Adora3	IDA		Mouse	PMID:12817016
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	Adora3	IDA		Mouse	PMID:12817016
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	Adora3	IMP	MGI:MGI:2155986	Mouse	PMID:12817016
Biological Process	GO:0050729	positive regulation of inflammatory response	Adora3	IMP	MGI:MGI:2155986	Mouse	PMID:15240734
Biological Process	GO:0050729	positive regulation of inflammatory response	Adora3	IGI	MGI:MGI:87916	Mouse	PMID:15240734
Biological Process	GO:0002687	positive regulation of leukocyte migration	Adora3	IGI	MGI:MGI:87916	Mouse	PMID:15240734
Biological Process	GO:0002687	positive regulation of leukocyte migration	Adora3	IMP	MGI:MGI:2155986	Mouse	PMID:15240734
Biological Process	GO:0043306	positive regulation of mast cell degranulation	Adora3	IDA		Mouse	PMID:12817016
Biological Process	GO:0043306	positive regulation of mast cell degranulation	Adora3	IMP	MGI:MGI:2155986	Mouse	PMID:12817016
Biological Process	GO:0070257	positive regulation of mucus secretion	Adora3	IMP		Mouse	PMID:15240734
Biological Process	GO:0070257	positive regulation of mucus secretion	Adora3	IMP	MGI:MGI:2155986	Mouse	PMID:15240734
Biological Process	GO:0070257	positive regulation of mucus secretion	Adora3	IGI	MGI:MGI:87916	Mouse	PMID:15240734
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Adora3	IDA		Mouse	PMID:12817016
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Adora3	EXP		Rat	PMID:8987783|RGD:13702310
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Adora3	IDA		Rat	PMID:8987783|RGD:13702310
Biological Process	GO:0014061	regulation of norepinephrine secretion	Adora3	IMP		Rat	PMID:16539684|RGD:1625639

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern