Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Adra1a

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ADRA1A
- Mouse genes Adra1a
- Rat genes Adra1a
- Zfish genes adra1aa,adra1ab
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adra1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004937	alpha1-adrenergic receptor activity	Adra1a	IDA		Mouse	PMID:9630362
Molecular Function	GO:0004937	alpha1-adrenergic receptor activity	Adra1a	IMP	MGI:MGI:2387663	Mouse	PMID:12782680
Molecular Function	GO:0004937	alpha1-adrenergic receptor activity	Adra1a	IDA		Rat	PMID:7935320\|RGD:69745
Molecular Function	GO:0005515	protein binding	ADRA1A	IPI	UniProtKB:Q5BKX8	Human	PMID:24567387
Molecular Function	GO:0046982	protein heterodimerization activity	ADRA1A	IDA		Human	PMID:22120526
Cellular Component	GO:0005737	cytoplasm	ADRA1A	IDA		Human	PMID:24567387
Cellular Component	GO:0005829	cytosol	ADRA1A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0098691	dopaminergic synapse	Adra1a	IDA		Rat	PMID:22588352\|RGD:13702255
Cellular Component	GO:0098982	GABA-ergic synapse	Adra1a	IDA		Rat	PMID:22588352\|RGD:13702255
Cellular Component	GO:0098978	glutamatergic synapse	Adra1a	EXP		Rat	PMID:12548707\|RGD:13702265
Cellular Component	GO:0098978	glutamatergic synapse	Adra1a	IDA		Rat	PMID:12548707\|RGD:13702265
Cellular Component	GO:0098978	glutamatergic synapse	Adra1a	IDA		Rat	PMID:22588352\|RGD:13702255
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ADRA1A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	Adra1a	IDA		Mouse	PMID:9630362
Cellular Component	GO:0016020	membrane	Adra1a	IDA		Rat	PMID:20511116\|RGD:5688334
Cellular Component	GO:0031965	nuclear membrane	ADRA1A	IDA		Human	PMID:22120526
Cellular Component	GO:0005654	nucleoplasm	ADRA1A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ADRA1A	IDA		Human	PMID:22120526
Cellular Component	GO:0005886	plasma membrane	ADRA1A	IDA		Human	PMID:24567387
Cellular Component	GO:0005886	plasma membrane	Adra1a	IDA		Rat	PMID:18467629\|RGD:5688343
Cellular Component	GO:0045211	postsynaptic membrane	Adra1a	IDA		Rat	PMID:22588352\|RGD:13702255
Cellular Component	GO:0042734	presynaptic membrane	Adra1a	IDA		Rat	PMID:22588352\|RGD:13702255
Cellular Component	GO:0030315	T-tubule	Adra1a	IDA		Rat	PMID:18467629\|RGD:5688343
Cellular Component	GO:0030018	Z disc	Adra1a	IDA		Rat	PMID:18467629\|RGD:5688343
Biological Process	GO:0007202	activation of phospholipase C activity	Adra1a	IDA		Rat	PMID:7935320\|RGD:69745
Biological Process	GO:0007512	adult heart development	Adra1a	IGI	MGI:MGI:104774	Mouse	PMID:12782680
Biological Process	GO:0060402	calcium ion transport into cytosol	Adra1a	IMP		Rat	PMID:19011682\|RGD:5688340
Biological Process	GO:0061049	cell growth involved in cardiac muscle cell development	Adra1a	IGI	MGI:MGI:104774	Mouse	PMID:12782680
Biological Process	GO:0000165	MAPK cascade	Adra1a	IGI	MGI:MGI:104774	Mouse	PMID:12782680
Biological Process	GO:0060073	micturition	Adra1a	IMP		Rat	PMID:20668103\|RGD:5688347
Biological Process	GO:0010507	negative regulation of autophagy	Adra1a	IDA		Mouse	PMID:27994061
Biological Process	GO:0001985	negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure	Adra1a	IMP	MGI:MGI:2387663	Mouse	PMID:12093905
Biological Process	GO:0035024	negative regulation of Rho protein signal transduction	Adra1a	IMP		Rat	PMID:18332105\|RGD:8554725
Biological Process	GO:0150099	neuron-glial cell signaling	Adra1a	IGI	UniProtKB:P97714,UniProtKB:P97717	Mouse	MGI:MGI:6294365\|PMID:10493741
Biological Process	GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	Adra1a	IMP	MGI:MGI:2387663	Mouse	PMID:12093905
Biological Process	GO:0035265	organ growth	Adra1a	IGI	MGI:MGI:104774	Mouse	PMID:12782680
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Adra1a	IDA		Mouse	PMID:9590558
Biological Process	GO:0097195	pilomotor reflex	Adra1a	IDA		Mouse	MGI:MGI:4947862\|PMID:21335239
Biological Process	GO:0045760	positive regulation of action potential	Adra1a	IMP		Rat	PMID:17337632\|RGD:1625774
Biological Process	GO:0060452	positive regulation of cardiac muscle contraction	Adra1a	IMP		Rat	PMID:19011682\|RGD:5688340
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	Adra1a	IDA		Mouse	PMID:27994061
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Adra1a	IMP		Rat	PMID:17588332\|RGD:1625773
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Adra1a	IMP		Rat	PMID:19011682\|RGD:5688340
Biological Process	GO:0010460	positive regulation of heart rate	Adra1a	IMP		Rat	PMID:22040923\|RGD:5688308
Biological Process	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine	Adra1a	IGI	MGI:MGI:104774	Mouse	PMID:12782680
Biological Process	GO:0043410	positive regulation of MAPK cascade	ADRA1A	IDA		Human	PMID:22120526
Biological Process	GO:0043410	positive regulation of MAPK cascade	Adra1a	IGI	MGI:MGI:104774	Mouse	PMID:12782680
Biological Process	GO:1903997	positive regulation of non-membrane spanning protein tyrosine kinase activity	Adra1a	IDA		Mouse	PMID:27994061
Biological Process	GO:0090037	positive regulation of protein kinase C signaling	Adra1a	IDA		Rat	PMID:18467629\|RGD:5688343
Biological Process	GO:0090037	positive regulation of protein kinase C signaling	Adra1a	IMP		Rat	PMID:19011682\|RGD:5688340
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	Adra1a	IDA		Mouse	MGI:MGI:4947862\|PMID:21335239
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	Adra1a	IMP		Rat	PMID:19041301\|RGD:5688345
Biological Process	GO:0032230	positive regulation of synaptic transmission, GABAergic	Adra1a	IDA		Rat	PMID:14532911\|RGD:1625778
Biological Process	GO:0003084	positive regulation of systemic arterial blood pressure	Adra1a	IMP		Rat	PMID:22040923\|RGD:5688308
Biological Process	GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine	Adra1a	IGI	MGI:MGI:104774	Mouse	PMID:12595294
Biological Process	GO:0045907	positive regulation of vasoconstriction	Adra1a	IDA		Rat	PMID:15877108\|RGD:1625777
Biological Process	GO:0045907	positive regulation of vasoconstriction	Adra1a	IMP		Rat	PMID:19011682\|RGD:5688340
Biological Process	GO:0045907	positive regulation of vasoconstriction	Adra1a	IMP		Rat	PMID:22040923\|RGD:5688308
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Adra1a	EXP		Rat	PMID:12548707\|RGD:13702265
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Adra1a	IDA		Rat	PMID:12548707\|RGD:13702265
Biological Process	GO:0008217	regulation of blood pressure	Adra1a	IMP		Mouse	PMID:26531127
Biological Process	GO:0009725	response to hormone	Adra1a	IMP		Rat	PMID:11684150\|RGD:1625783
Biological Process	GO:0009410	response to xenobiotic stimulus	Adra1a	IMP		Rat	PMID:17588332\|RGD:1625773

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.