Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Adra1b

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ADRA1B
- Mouse genes Adra1b
- Rat genes Adra1b
- Zfish genes adra1ba,adra1bb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adra1b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004937	alpha1-adrenergic receptor activity	Adra1b	IMP	MGI:MGI:2148638	Mouse	PMID:12782680
Molecular Function	GO:0004937	alpha1-adrenergic receptor activity	Adra1b	IMP	MGI:MGI:2148638	Mouse	PMID:9326654
Molecular Function	GO:0004937	alpha1-adrenergic receptor activity	Adra1b	IDA		Mouse	PMID:11923452
Molecular Function	GO:0004937	alpha1-adrenergic receptor activity	Adra1b	IDA		Mouse	PMID:7911220
Molecular Function	GO:0004937	alpha1-adrenergic receptor activity	Adra1b	IGI	MGI:MGI:104773	Mouse	PMID:12782680
Molecular Function	GO:0004937	alpha1-adrenergic receptor activity	Adra1b	IDA		Rat	PMID:12054611\|RGD:634393
Molecular Function	GO:0005515	protein binding	ADRA1B	IPI	UniProtKB:Q5BKX8	Human	PMID:24567387
Molecular Function	GO:0046982	protein heterodimerization activity	ADRA1B	IDA		Human	PMID:22120526
Cellular Component	GO:0005737	cytoplasm	ADRA1B	IDA		Human	PMID:24567387
Cellular Component	GO:0014704	intercalated disc	Adra1b	IDA		Rat	PMID:18467629\|RGD:5688343
Cellular Component	GO:0016020	membrane	Adra1b	IDA		Mouse	PMID:11923452
Cellular Component	GO:0016020	membrane	Adra1b	IDA		Rat	PMID:11896179\|RGD:1625782
Cellular Component	GO:0031965	nuclear membrane	ADRA1B	IDA		Human	PMID:22120526
Cellular Component	GO:0005634	nucleus	ADRA1B	IDA		Human	PMID:22120526
Cellular Component	GO:0005886	plasma membrane	ADRA1B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ADRA1B	IDA		Human	PMID:24567387
Cellular Component	GO:0030315	T-tubule	Adra1b	IDA		Rat	PMID:18467629\|RGD:5688343
Biological Process	GO:0007512	adult heart development	Adra1b	IGI	MGI:MGI:104773	Mouse	PMID:12782680
Biological Process	GO:0048148	behavioral response to cocaine	Adra1b	IMP	MGI:MGI:2148638	Mouse	PMID:11923452
Biological Process	GO:0001974	blood vessel remodeling	Adra1b	IMP	MGI:MGI:2148638	Mouse	PMID:15231500
Biological Process	GO:0061049	cell growth involved in cardiac muscle cell development	Adra1b	IGI	MGI:MGI:104773	Mouse	PMID:12782680
Biological Process	GO:0042593	glucose homeostasis	Adra1b	IMP	MGI:MGI:2148638	Mouse	PMID:14581480
Biological Process	GO:0005980	glycogen catabolic process	Adra1b	IMP	MGI:MGI:2148638	Mouse	PMID:14581480
Biological Process	GO:0007626	locomotory behavior	Adra1b	IMP	MGI:MGI:2148638	Mouse	PMID:11222061
Biological Process	GO:0045818	negative regulation of glycogen catabolic process	Adra1b	IMP	MGI:MGI:2148638	Mouse	PMID:14581480
Biological Process	GO:0035024	negative regulation of Rho protein signal transduction	Adra1b	IMP		Rat	PMID:18332105\|RGD:8554725
Biological Process	GO:0150099	neuron-glial cell signaling	Adra1b	IGI	UniProtKB:P97714,UniProtKB:P97718	Mouse	MGI:MGI:6294365\|PMID:10493741
Biological Process	GO:0035265	organ growth	Adra1b	IGI	MGI:MGI:104773	Mouse	PMID:12782680
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Adra1b	IDA		Rat	PMID:12054611\|RGD:634393
Biological Process	GO:0045819	positive regulation of glycogen catabolic process	Adra1b	IMP	MGI:MGI:2148638	Mouse	PMID:14581480
Biological Process	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine	Adra1b	IGI	MGI:MGI:104773	Mouse	PMID:12782680
Biological Process	GO:0043410	positive regulation of MAPK cascade	ADRA1B	IDA		Human	PMID:22120526
Biological Process	GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine	Adra1b	IGI	MGI:MGI:104773	Mouse	PMID:12595294
Biological Process	GO:0008217	regulation of blood pressure	Adra1b	IMP		Mouse	PMID:26531127
Biological Process	GO:0001975	response to amphetamine	Adra1b	IMP	MGI:MGI:2148638	Mouse	PMID:11923452
Biological Process	GO:0001975	response to amphetamine	Adra1b	IMP	MGI:MGI:2148638	Mouse	PMID:12871582
Biological Process	GO:0043627	response to estrogen	Adra1b	IEP		Rat	PMID:11896179\|RGD:1625782
Biological Process	GO:0009725	response to hormone	Adra1b	IMP		Rat	PMID:12270752\|RGD:1625781
Biological Process	GO:0043278	response to morphine	Adra1b	IMP	MGI:MGI:2148638	Mouse	PMID:11923452
Biological Process	GO:0048545	response to steroid hormone	Adra1b	IMP		Rat	PMID:12818703\|RGD:1625779
Biological Process	GO:0009410	response to xenobiotic stimulus	Adra1b	IEP		Rat	PMID:16309668\|RGD:1625776
Biological Process	GO:0001987	vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure	Adra1b	IMP	MGI:MGI:2148638	Mouse	PMID:9326654
Biological Process	GO:0008542	visual learning	Adra1b	IMP	MGI:MGI:2148638	Mouse	PMID:11222061

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.