Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Adra2a

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ADRA2A
- Mouse genes Adra2a
- Rat genes Adra2a
- Zfish genes adra2a
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adra2a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004935	adrenergic receptor activity	Adra2a	IMP		Mouse	PMID:15218143
Molecular Function	GO:0031696	alpha-2C adrenergic receptor binding	ADRA2A	IPI	UniProtKB:P18825	Human	PMID:16605244
Molecular Function	GO:0004938	alpha2-adrenergic receptor activity	ADRA2A	IDA		Human	PMID:10948191
Molecular Function	GO:0004938	alpha2-adrenergic receptor activity	Adra2a	IMP		Mouse	PMID:17992256
Molecular Function	GO:0004938	alpha2-adrenergic receptor activity	Adra2a	IDA		Rat	PMID:1645350\|RGD:1304193
Molecular Function	GO:0004938	alpha2-adrenergic receptor activity	adra2a	IDA		Zfish	PMID:15655522
Molecular Function	GO:0051379	epinephrine binding	ADRA2A	IDA		Human	PMID:10948191
Molecular Function	GO:0051379	epinephrine binding	ADRA2A	IDA		Human	PMID:2823383
Molecular Function	GO:0032795	heterotrimeric G-protein binding	ADRA2A	IDA		Human	PMID:10948191
Molecular Function	GO:0140677	molecular function activator activity	Adra2a	IMP		Mouse	PMID:17992256
Molecular Function	GO:0051380	norepinephrine binding	ADRA2A	IDA		Human	PMID:2823383
Molecular Function	GO:0005515	protein binding	ADRA2A	IPI	UniProtKB:P51693	Human	PMID:16531006
Molecular Function	GO:0005515	protein binding	Adra2a	IPI	UniProtKB:Q14232	Mouse	MGI:MGI:894915\|PMID:9235896
Molecular Function	GO:0046982	protein heterodimerization activity	ADRA2A	IPI	UniProtKB:P18825	Human	PMID:16605244
Molecular Function	GO:0042803	protein homodimerization activity	ADRA2A	IDA		Human	PMID:16605244
Molecular Function	GO:0019901	protein kinase binding	ADRA2A	IPI	UniProtKB:P21146	Human	PMID:15653687
Molecular Function	GO:0031996	thioesterase binding	ADRA2A	IPI	UniProtKB:P09936	Human	PMID:19477270
Cellular Component	GO:0043679	axon terminus	Adra2a	IDA		Rat	PMID:12379250\|RGD:1304256
Cellular Component	GO:0005737	cytoplasm	ADRA2A	IDA		Human	PMID:19477270
Cellular Component	GO:0005737	cytoplasm	Adra2a	IDA		Rat	PMID:15475682\|RGD:1625184
Cellular Component	GO:0098691	dopaminergic synapse	Adra2a	EXP		Mouse	PMID:11927164
Cellular Component	GO:0098691	dopaminergic synapse	Adra2a	IDA		Mouse	PMID:11927164
Cellular Component	GO:0098691	dopaminergic synapse	Adra2a	IMP		Mouse	PMID:11927164
Cellular Component	GO:0098982	GABA-ergic synapse	Adra2a	IDA		Rat	PMID:9596526\|RGD:13702430
Cellular Component	GO:0098978	glutamatergic synapse	Adra2a	EXP		Rat	PMID:9596526\|RGD:13702430
Cellular Component	GO:0098978	glutamatergic synapse	Adra2a	IDA		Rat	PMID:9596526\|RGD:13702430
Cellular Component	GO:0043025	neuronal cell body	Adra2a	IDA		Rat	PMID:12379250\|RGD:1304256
Cellular Component	GO:0005886	plasma membrane	ADRA2A	IDA		Human	PMID:10948191
Cellular Component	GO:0005886	plasma membrane	ADRA2A	IDA		Human	PMID:10948198
Cellular Component	GO:0005886	plasma membrane	ADRA2A	IDA		Human	PMID:2823383
Cellular Component	GO:0005886	plasma membrane	Adra2a	IDA		Rat	PMID:12373741\|RGD:631769
Cellular Component	GO:0005886	plasma membrane	Adra2a	IDA		Rat	PMID:12398941\|RGD:631753
Cellular Component	GO:0005886	plasma membrane	Adra2a	IDA		Rat	PMID:15475682\|RGD:1625184
Cellular Component	GO:0098839	postsynaptic density membrane	Adra2a	IDA		Rat	PMID:9596526\|RGD:13702430
Cellular Component	GO:0045211	postsynaptic membrane	Adra2a	EXP		Rat	PMID:9596526\|RGD:13702430
Cellular Component	GO:0045211	postsynaptic membrane	Adra2a	IDA		Rat	PMID:9596526\|RGD:13702430
Cellular Component	GO:0048787	presynaptic active zone membrane	Adra2a	IDA		Rat	PMID:9596526\|RGD:13702430
Cellular Component	GO:0043235	receptor complex	ADRA2A	IDA		Human	PMID:10948191
Cellular Component	GO:0045202	synapse	Adra2a	IDA		Rat	PMID:15475682\|RGD:1625184
Biological Process	GO:0032147	activation of protein kinase activity	ADRA2A	IDA		Human	PMID:15653687
Biological Process	GO:0032148	activation of protein kinase B activity	ADRA2A	IDA		Human	PMID:17215105
Biological Process	GO:0002526	acute inflammatory response	Adra2a	IMP		Rat	PMID:19894027\|RGD:6480483
Biological Process	GO:0071881	adenylate cyclase-inhibiting adrenergic receptor signaling pathway	ADRA2A	IDA		Human	PMID:10948191
Biological Process	GO:0071881	adenylate cyclase-inhibiting adrenergic receptor signaling pathway	adra2a	IDA		Zfish	PMID:15655522\|ZFIN:ZDB-PUB-050120-13
Biological Process	GO:0071875	adrenergic receptor signaling pathway	ADRA2A	IDA		Human	PMID:10948191
Biological Process	GO:0032870	cellular response to hormone stimulus	ADRA2A	IGI	UniProtKB:P25962	Human	PMID:10948198
Biological Process	GO:0006260	DNA replication	Adra2a	IMP		Rat	PMID:15351511\|RGD:1625185
Biological Process	GO:0042596	fear response	Adra2a	IMP		Mouse	PMID:15105370
Biological Process	GO:0007565	female pregnancy	Adra2a	IMP		Rat	PMID:19450576\|RGD:6893569
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ADRA2A	IDA		Human	PMID:17215105
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ADRA2A	IDA		Human	PMID:17655843
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Adra2a	IDA		Mouse	PMID:15218143
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Adra2a	IMP		Rat	PMID:19965390\|RGD:2316628
Biological Process	GO:0042593	glucose homeostasis	ADRA2A	IMP		Human	PMID:10952463
Biological Process	GO:0042593	glucose homeostasis	Adra2a	IMP		Rat	PMID:19965390\|RGD:2316628
Biological Process	GO:0045955	negative regulation of calcium ion-dependent exocytosis	Adra2a	IMP		Rat	PMID:19965390\|RGD:2316628
Biological Process	GO:0046676	negative regulation of insulin secretion	ADRA2A	IMP		Human	PMID:10952463
Biological Process	GO:0046676	negative regulation of insulin secretion	Adra2a	IMP		Mouse	PMID:1898674
Biological Process	GO:0046676	negative regulation of insulin secretion	Adra2a	IDA		Mouse	PMID:1898674
Biological Process	GO:0046676	negative regulation of insulin secretion	Adra2a	IMP		Mouse	PMID:17992256
Biological Process	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	ADRA2A	IMP		Human	PMID:19965390
Biological Process	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	Adra2a	IMP		Rat	PMID:19965390\|RGD:2316628
Biological Process	GO:0050995	negative regulation of lipid catabolic process	ADRA2A	IGI	UniProtKB:P25962	Human	PMID:10948198
Biological Process	GO:0070473	negative regulation of uterine smooth muscle contraction	Adra2a	IMP		Rat	PMID:17664026\|RGD:6893570
Biological Process	GO:0071882	phospholipase C-activating adrenergic receptor signaling pathway	ADRA2A	IDA		Human	PMID:10948191
Biological Process	GO:0030335	positive regulation of cell migration	ADRA2A	IMP		Human	PMID:17655843
Biological Process	GO:0001819	positive regulation of cytokine production	ADRA2A	IDA		Human	PMID:17655843
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	ADRA2A	IDA		Human	PMID:17655843
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ADRA2A	IDA		Human	PMID:19477270
Biological Process	GO:0043410	positive regulation of MAPK cascade	ADRA2A	IDA		Human	PMID:10948191
Biological Process	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	ADRA2A	IDA		Human	PMID:17655843
Biological Process	GO:0090303	positive regulation of wound healing	ADRA2A	IMP		Human	PMID:17655843
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Adra2a	EXP		Mouse	PMID:11927164
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Adra2a	IDA		Mouse	PMID:11927164
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Adra2a	IMP		Mouse	PMID:11927164
Biological Process	GO:0035624	receptor transactivation	ADRA2A	IDA		Human	PMID:17215105
Biological Process	GO:0035624	receptor transactivation	ADRA2A	IDA		Human	PMID:17655843
Biological Process	GO:0007165	signal transduction	Adra2a	IEP		Rat	PMID:12817185\|RGD:1304393
Biological Process	GO:0050955	thermoception	Adra2a	IDA		Rat	PMID:20110357\|RGD:6480493
Biological Process	GO:0042311	vasodilation	Adra2a	IDA		Rat	PMID:20837990\|RGD:6480489

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.