Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ADRA2B
  • Mouse genes Adra2b
  • Rat genes Adra2b
  • Zfish genes adra2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adra2b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004935	adrenergic receptor activity	Adra2b	IMP		Mouse	PMID:15218143
Molecular Function	GO:0004938	alpha2-adrenergic receptor activity	ADRA2B	IDA		Human	PMID:17215105
Molecular Function	GO:0004938	alpha2-adrenergic receptor activity	Adra2b	IDA		Mouse	PMID:12068299
Molecular Function	GO:0004938	alpha2-adrenergic receptor activity	Adra2b	IDA		Rat	PMID:2158103|RGD:631714
Molecular Function	GO:0004938	alpha2-adrenergic receptor activity	adra2b	IDA		Zfish	PMID:15655522
Molecular Function	GO:0051379	epinephrine binding	ADRA2B	IDA		Human	PMID:17215105
Molecular Function	GO:0005515	protein binding	ADRA2B	IPI	UniProtKB:P51693	Human	PMID:16531006
Molecular Function	GO:0005515	protein binding	ADRA2B	IPI	UniProtKB:Q9ULW5	Human	PMID:23105096
Molecular Function	GO:0005515	protein binding	ADRA2B	IPI	UniProtKB:Q96SB3	Human	PMID:24114805
Molecular Function	GO:0005515	protein binding	ADRA2B	IPI	UniProtKB:Q9NZ52	Human	PMID:26811329
Molecular Function	GO:0005515	protein binding	ADRA2B	IPI	UniProtKB:Q9UJY4|UniProtKB:Q9UJY5	Human	PMID:27901063
Molecular Function	GO:0005515	protein binding	Adra2b	IPI	UniProtKB:Q14232	Mouse	MGI:MGI:894915|PMID:9235896
Molecular Function	GO:0005515	protein binding	Adra2b	IPI	UniProtKB:Q9UJY4	Rat	PMID:27901063|RGD:14697718
Molecular Function	GO:0005515	protein binding	Adra2b	IPI	UniProtKB:Q9UJY5	Rat	PMID:27901063|RGD:14697718
Cellular Component	GO:0009986	cell surface	ADRA2B	IDA		Human	PMID:27901063
Cellular Component	GO:0005829	cytosol	ADRA2B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ADRA2B	IDA		Human	GO_REF:0000052
Biological Process	GO:0032148	activation of protein kinase B activity	ADRA2B	IDA		Human	PMID:17215105
Biological Process	GO:0071881	adenylate cyclase-inhibiting adrenergic receptor signaling pathway	adra2b	IDA		Zfish	PMID:15655522|ZFIN:ZDB-PUB-050120-13
Biological Process	GO:0071875	adrenergic receptor signaling pathway	ADRA2B	IDA		Human	PMID:17215105
Biological Process	GO:0001525	angiogenesis	Adra2b	IMP	MGI:MGI:1857118	Mouse	PMID:12068299
Biological Process	GO:0007565	female pregnancy	Adra2b	IMP		Rat	PMID:19450576|RGD:6893569
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ADRA2B	IDA		Human	PMID:17215105
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Adra2b	IDA		Mouse	PMID:15218143
Biological Process	GO:0000165	MAPK cascade	Adra2b	IMP	MGI:MGI:1857118	Mouse	PMID:12068299
Biological Process	GO:0045777	positive regulation of blood pressure	Adra2b	IMP		Rat	PMID:17070424|RGD:2313548
Biological Process	GO:0043410	positive regulation of MAPK cascade	ADRA2B	IDA		Human	PMID:17215105
Biological Process	GO:0043410	positive regulation of MAPK cascade	Adra2b	IMP		Rat	PMID:11891218|RGD:1304238
Biological Process	GO:0045666	positive regulation of neuron differentiation	ADRA2B	IDA		Human	PMID:17215105
Biological Process	GO:0070474	positive regulation of uterine smooth muscle contraction	Adra2b	IMP		Rat	PMID:17664026|RGD:6893570
Biological Process	GO:0070474	positive regulation of uterine smooth muscle contraction	Adra2b	IMP		Rat	PMID:19634638|RGD:2313546
Biological Process	GO:0035624	receptor transactivation	ADRA2B	IDA		Human	PMID:17215105
Biological Process	GO:0003056	regulation of vascular associated smooth muscle contraction	Adra2b	IMP		Rat	PMID:18054907|RGD:2313547

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern