Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ADRA2C
  • Mouse genes Adra2c
  • Rat genes Adra2c
  • Zfish genes adra2c
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adra2c

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031694	alpha-2A adrenergic receptor binding	ADRA2C	IPI	UniProtKB:P08913	Human	PMID:16605244
Molecular Function	GO:0004938	alpha2-adrenergic receptor activity	ADRA2C	IDA		Human	PMID:17215105
Molecular Function	GO:0004938	alpha2-adrenergic receptor activity	adra2c	IDA		Zfish	PMID:11112429|ZFIN:ZDB-PUB-001221-12
Molecular Function	GO:0004938	alpha2-adrenergic receptor activity	adra2c	IDA		Zfish	PMID:15655522
Molecular Function	GO:0051379	epinephrine binding	ADRA2C	IDA		Human	PMID:17215105
Molecular Function	GO:0004930	G protein-coupled receptor activity	Adra2c	IDA		Mouse	PMID:14712229
Molecular Function	GO:0005515	protein binding	ADRA2C	IPI	UniProtKB:P51693	Human	PMID:16531006
Molecular Function	GO:0005515	protein binding	ADRA2C	IPI	UniProtKB:O14770-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ADRA2C	IPI	UniProtKB:O14964	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ADRA2C	IPI	UniProtKB:O76011	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ADRA2C	IPI	UniProtKB:Q13064	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ADRA2C	IPI	UniProtKB:Q2WGJ6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ADRA2C	IPI	UniProtKB:Q7Z4N8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ADRA2C	IPI	UniProtKB:Q8N4L8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ADRA2C	IPI	UniProtKB:Q99750	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ADRA2C	IPI	UniProtKB:Q9NZC7-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ADRA2C	IPI	UniProtKB:Q9Y2B0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ADRA2C	IPI	UniProtKB:Q9Y6H1	Human	PMID:32296183
Molecular Function	GO:0046982	protein heterodimerization activity	ADRA2C	IPI	UniProtKB:P08913	Human	PMID:16605244
Molecular Function	GO:0042803	protein homodimerization activity	ADRA2C	IDA		Human	PMID:16605244
Cellular Component	GO:0030424	axon	Adra2c	IDA		Rat	PMID:15207357|RGD:1304339
Cellular Component	GO:0043679	axon terminus	Adra2c	IDA		Rat	PMID:12379250|RGD:1304256
Cellular Component	GO:0043679	axon terminus	Adra2c	IDA		Rat	PMID:12591145|RGD:1304361
Cellular Component	GO:0005737	cytoplasm	ADRA2C	IDA		Human	PMID:16605244
Cellular Component	GO:0098978	glutamatergic synapse	Adra2c	EXP		Rat	PMID:9552127|RGD:13702163
Cellular Component	GO:0098978	glutamatergic synapse	Adra2c	IDA		Rat	PMID:9552127|RGD:13702163
Cellular Component	GO:0043025	neuronal cell body	Adra2c	IDA		Rat	PMID:12379250|RGD:1304256
Cellular Component	GO:0005886	plasma membrane	ADRA2C	IDA		Human	PMID:16605244
Cellular Component	GO:0098839	postsynaptic density membrane	Adra2c	EXP		Rat	PMID:9552127|RGD:13702163
Cellular Component	GO:0098839	postsynaptic density membrane	Adra2c	IDA		Rat	PMID:9552127|RGD:13702163
Cellular Component	GO:0045211	postsynaptic membrane	Adra2c	IDA		Rat	PMID:9552127|RGD:13702163
Biological Process	GO:0032148	activation of protein kinase B activity	ADRA2C	IDA		Human	PMID:17215105
Biological Process	GO:0071881	adenylate cyclase-inhibiting adrenergic receptor signaling pathway	adra2c	IDA		Zfish	PMID:15655522|ZFIN:ZDB-PUB-050120-13
Biological Process	GO:0071875	adrenergic receptor signaling pathway	ADRA2C	IDA		Human	PMID:17215105
Biological Process	GO:0071875	adrenergic receptor signaling pathway	adra2c	IDA		Zfish	PMID:15655522|ZFIN:ZDB-PUB-050120-13
Biological Process	GO:0007565	female pregnancy	Adra2c	IMP		Rat	PMID:19450576|RGD:6893569
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ADRA2C	IDA		Human	PMID:17215105
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Adra2c	IDA		Mouse	PMID:14712229
Biological Process	GO:0070473	negative regulation of uterine smooth muscle contraction	Adra2c	IMP		Rat	PMID:17664026|RGD:6893570
Biological Process	GO:0043410	positive regulation of MAPK cascade	ADRA2C	IDA		Human	PMID:17215105
Biological Process	GO:0045666	positive regulation of neuron differentiation	ADRA2C	IDA		Human	PMID:17215105
Biological Process	GO:0045907	positive regulation of vasoconstriction	Adra2c	IMP		Rat	PMID:20862454|RGD:6893567
Biological Process	GO:0035624	receptor transactivation	ADRA2C	IDA		Human	PMID:17215105
Biological Process	GO:0051930	regulation of sensory perception of pain	Adra2c	IMP		Rat	PMID:20007733|RGD:6893568

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern