Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ADRB1
  • Mouse genes Adrb1
  • Rat genes Adrb1
  • Zfish genes adrb1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adrb1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031694	alpha-2A adrenergic receptor binding	ADRB1	IPI	UniProtKB:P18871	Human	PMID:12529373
Molecular Function	GO:0043176	amine binding	Adrb1	IPI	CHEBI:174690	Rat	PMID:6289140|RGD:2301944
Molecular Function	GO:0004940	beta1-adrenergic receptor activity	Adrb1	IDA		Mouse	PMID:7738011
Molecular Function	GO:0004940	beta1-adrenergic receptor activity	Adrb1	IMP	MGI:MGI:1857120	Mouse	PMID:8693001
Molecular Function	GO:0004940	beta1-adrenergic receptor activity	Adrb1	IDA		Mouse	PMID:9305915
Molecular Function	GO:0004940	beta1-adrenergic receptor activity	Adrb1	IDA		Rat	PMID:12514203|RGD:632158
Molecular Function	GO:0099579	G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	Adrb1	IDA		Mouse	PMID:10595521
Molecular Function	GO:0099579	G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	Adrb1	IMP		Mouse	PMID:10595521
Molecular Function	GO:0099579	G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	Adrb1	EXP		Mouse	PMID:10595521
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ADRB1	IDA		Human	PMID:12391161
Molecular Function	GO:0030165	PDZ domain binding	ADRB1	IPI	UniProtKB:P31016	Human	PMID:11526121
Molecular Function	GO:0030165	PDZ domain binding	ADRB1	IPI	UniProtKB:Q86UL8	Human	PMID:11526121
Molecular Function	GO:0005515	protein binding	ADRB1	IPI	UniProtKB:Q9Y4G8	Human	PMID:12391161
Molecular Function	GO:0005515	protein binding	ADRB1	IPI	UniProtKB:P31016	Human	PMID:16316992
Molecular Function	GO:0005515	protein binding	ADRB1	IPI	UniProtKB:Q5TCQ9	Human	PMID:16316992
Molecular Function	GO:0005515	protein binding	ADRB1	IPI	UniProtKB:Q86UL8	Human	PMID:16316992
Molecular Function	GO:0005515	protein binding	ADRB1	IPI	UniProtKB:P31016	Human	PMID:16533813
Molecular Function	GO:0005515	protein binding	ADRB1	IPI	UniProtKB:Q86UL8	Human	PMID:16533813
Molecular Function	GO:0005515	protein binding	ADRB1	IPI	UniProtKB:P30542	Human	PMID:23291003
Molecular Function	GO:0005515	protein binding	ADRB1	IPI	UniProtKB:P14270	Human	PMID:23381222
Molecular Function	GO:0005515	protein binding	Adrb1	IPI	UniProtKB:Q01063	Mouse	MGI:MGI:3773471|PMID:18188154
Molecular Function	GO:0005515	protein binding	Adrb1	IPI	UniProtKB:P18762	Mouse	MGI:MGI:5004728|PMID:21614075
Molecular Function	GO:0005515	protein binding	Adrb1	IPI	UniProtKB:Q9JK71	Rat	PMID:16316992|RGD:8553792
Molecular Function	GO:0005515	protein binding	Adrb1	IPI	RGD:620829	Rat	PMID:16940053|RGD:2313215
Molecular Function	GO:0046982	protein heterodimerization activity	ADRB1	IPI	UniProtKB:P18871	Human	PMID:12529373
Cellular Component	GO:0005737	cytoplasm	Adrb1	IDA		Rat	PMID:17337326|RGD:5129148
Cellular Component	GO:0005769	early endosome	ADRB1	IDA		Human	PMID:21540189
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Adrb1	IDA		Rat	PMID:2858976|RGD:2301949
Cellular Component	GO:0016020	membrane	Adrb1	IMP	MGI:MGI:1857120	Mouse	PMID:8693001
Cellular Component	GO:0016020	membrane	Adrb1	IDA		Rat	PMID:1686765|RGD:2301954
Cellular Component	GO:0098992	neuronal dense core vesicle	Adrb1	IDA		Mouse	PMID:21321602
Cellular Component	GO:0098992	neuronal dense core vesicle	Adrb1	EXP		Mouse	PMID:21321602
Cellular Component	GO:0005634	nucleus	Adrb1	IDA		Rat	PMID:16631628|RGD:5129153
Cellular Component	GO:0005886	plasma membrane	ADRB1	IDA		Human	PMID:11526121
Cellular Component	GO:0005886	plasma membrane	ADRB1	IDA		Human	PMID:21540189
Cellular Component	GO:0005886	plasma membrane	Adrb1	IDA		Rat	PMID:12391161|RGD:8554163
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Adrb1	IDA		Mouse	PMID:10595521
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Adrb1	IMP		Mouse	PMID:10595521
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Adrb1	EXP		Mouse	PMID:10595521
Biological Process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	ADRB1	IDA		Human	PMID:12391161
Biological Process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	ADRB1	IDA		Human	PMID:12529373
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Adrb1	IMP	MGI:MGI:1857120	Mouse	PMID:8693001
Biological Process	GO:0007568	aging	Adrb1	IEP		Rat	PMID:19883205|RGD:5129117
Biological Process	GO:0006915	apoptotic process	Adrb1	IDA		Rat	PMID:16820859|RGD:5129152
Biological Process	GO:0050873	brown fat cell differentiation	Adrb1	IGI	MGI:MGI:87939	Mouse	PMID:12387862
Biological Process	GO:0050873	brown fat cell differentiation	Adrb1	IGI	MGI:MGI:87938	Mouse	PMID:12387862
Biological Process	GO:0002024	diet induced thermogenesis	Adrb1	IGI	MGI:MGI:87938	Mouse	PMID:12161655
Biological Process	GO:0002024	diet induced thermogenesis	Adrb1	IGI	MGI:MGI:87939	Mouse	PMID:12161655
Biological Process	GO:0042596	fear response	Adrb1	IMP		Mouse	PMID:15066288
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Adrb1	IDA		Rat	PMID:12514203|RGD:632158
Biological Process	GO:0005980	glycogen catabolic process	Adrb1	IDA		Rat	PMID:17911346|RGD:5129142
Biological Process	GO:0031649	heat generation	Adrb1	IGI	MGI:MGI:87939	Mouse	PMID:12161655
Biological Process	GO:0031649	heat generation	Adrb1	IGI	MGI:MGI:87938	Mouse	PMID:12161655
Biological Process	GO:0060080	inhibitory postsynaptic potential	Adrb1	IMP		Rat	PMID:18262504|RGD:5129137
Biological Process	GO:0055088	lipid homeostasis	Adrb1	IMP		Rat	PMID:22457517|RGD:6893582
Biological Process	GO:0007613	memory	Adrb1	IMP		Rat	PMID:17961922|RGD:5129141
Biological Process	GO:0040015	negative regulation of multicellular organism growth	Adrb1	IGI	MGI:MGI:87939	Mouse	PMID:12387862
Biological Process	GO:0040015	negative regulation of multicellular organism growth	Adrb1	IGI	MGI:MGI:87938	Mouse	PMID:12387862
Biological Process	GO:0045986	negative regulation of smooth muscle contraction	Adrb1	IMP		Rat	PMID:18306009|RGD:5129131
Biological Process	GO:0035811	negative regulation of urine volume	Adrb1	IDA		Rat	PMID:7912752|RGD:5129105
Biological Process	GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	Adrb1	IGI	MGI:MGI:87938	Mouse	PMID:11641423
Biological Process	GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	Adrb1	IMP	MGI:MGI:1857120	Mouse	PMID:10358009
Biological Process	GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	Adrb1	IMP	MGI:MGI:1857120	Mouse	PMID:11641423
Biological Process	GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	Adrb1	IGI	MGI:MGI:87938	Mouse	PMID:10358009
Biological Process	GO:0045762	positive regulation of adenylate cyclase activity	Adrb1	IMP		Rat	PMID:21143600|RGD:8693686
Biological Process	GO:0106071	positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	Adrb1	IMP		Rat	PMID:18202135|RGD:5129138
Biological Process	GO:0043065	positive regulation of apoptotic process	Adrb1	IMP		Rat	PMID:17143192|RGD:7241557
Biological Process	GO:1905665	positive regulation of calcium ion import across plasma membrane	Adrb1	IDA		Rat	PMID:11408541|RGD:1598759
Biological Process	GO:2001259	positive regulation of cation channel activity	Adrb1	IDA		Rat	PMID:22505670|RGD:6893581
Biological Process	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	Adrb1	IMP		Rat	PMID:18194989|RGD:5129139
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Adrb1	IGI	UniProtKB:P18762,UniProtKB:P25962	Mouse	MGI:MGI:2388907|PMID:12387862
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Adrb1	IMP		Mouse	MGI:MGI:6101075|PMID:22728333
Biological Process	GO:0043547	positive regulation of GTPase activity	ADRB1	IDA		Human	PMID:12391161
Biological Process	GO:0010460	positive regulation of heart rate	Adrb1	IMP		Rat	PMID:9089896|RGD:5129112
Biological Process	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine	Adrb1	IMP	MGI:MGI:1857120	Mouse	PMID:10358009
Biological Process	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine	Adrb1	IMP	MGI:MGI:1857120	Mouse	PMID:8693001
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	Adrb1	IDA		Rat	PMID:21848869|RGD:8693685
Biological Process	GO:1900135	positive regulation of renin secretion into blood stream	Adrb1	IMP		Rat	PMID:15810988|RGD:7241562
Biological Process	GO:0046878	positive regulation of saliva secretion	Adrb1	IMP		Rat	PMID:18275933|RGD:5129135
Biological Process	GO:0003084	positive regulation of systemic arterial blood pressure	Adrb1	IMP		Rat	PMID:18931026|RGD:5129129
Biological Process	GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine	Adrb1	IDA		Mouse	PMID:7761854
Biological Process	GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine	Adrb1	IMP	MGI:MGI:1857120	Mouse	PMID:8693001
Biological Process	GO:0003061	positive regulation of the force of heart contraction by norepinephrine	Adrb1	IDA		Rat	PMID:19133992|RGD:5129126
Biological Process	GO:0033365	protein localization to organelle	Adrb1	IDA		Rat	PMID:22105697|RGD:6893637
Biological Process	GO:0051924	regulation of calcium ion transport	Adrb1	IDA		Rat	PMID:19133992|RGD:5129126
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	Adrb1	IDA		Rat	PMID:19525381|RGD:2317914
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	Adrb1	IMP		Rat	PMID:22216755|RGD:6893639
Biological Process	GO:0045187	regulation of circadian sleep/wake cycle, sleep	ADRB1	IMP		Human	PMID:25083013
Biological Process	GO:0045187	regulation of circadian sleep/wake cycle, sleep	Adrb1	IMP		Mouse	MGI:MGI:6368107|PMID:25083013
Biological Process	GO:0002027	regulation of heart rate	adrb1	IMP	ZFIN:ZDB-MRPHLNO-110525-2	Zfish	PMID:21490253
Biological Process	GO:0009409	response to cold	Adrb1	IGI	MGI:MGI:87939	Mouse	PMID:12387862
Biological Process	GO:0009409	response to cold	Adrb1	IGI	MGI:MGI:87939	Mouse	PMID:12161655
Biological Process	GO:0009409	response to cold	Adrb1	IGI	MGI:MGI:87938	Mouse	PMID:12161655
Biological Process	GO:0009409	response to cold	Adrb1	IGI	MGI:MGI:87938	Mouse	PMID:12387862
Biological Process	GO:0007266	Rho protein signal transduction	Adrb1	IMP		Rat	PMID:18306009|RGD:5129131
Biological Process	GO:0019233	sensory perception of pain	Adrb1	IMP		Rat	PMID:19283893|RGD:5129125
Biological Process	GO:0048845	venous blood vessel morphogenesis	adrb1	IGI	ZFIN:ZDB-CRISPR-211004-2,ZFIN:ZDB-CRISPR-211004-3,ZFIN:ZDB-CRISPR-211004-4,ZFIN:ZDB-CRISPR-211004-5,ZFIN:ZDB-MRPHLNO-110525-2	Zfish	PMID:33301422
Biological Process	GO:0042060	wound healing	Adrb1	IMP		Rat	PMID:19320892|RGD:5129124

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern