Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AFAP1L2
  • Mouse genes Afap1l2
  • Rat genes Afap1l2
  • Zfish genes afap1l2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Afap1l2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	Afap1l2	IPI	UniProtKB:P26450|UniProtKB:Q62656	Mouse	MGI:MGI:6285442|PMID:30667096
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	AFAP1L2	IDA		Human	PMID:17412687
Molecular Function	GO:0042169	SH2 domain binding	AFAP1L2	IPI	UniProtKB:P12931	Human	PMID:17412687
Molecular Function	GO:0017124	SH3 domain binding	AFAP1L2	IPI	UniProtKB:P12931	Human	PMID:17412687
Cellular Component	GO:0005737	cytoplasm	AFAP1L2	IDA		Human	PMID:17412687
Cellular Component	GO:0005829	cytosol	AFAP1L2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	AFAP1L2	IDA		Human	GO_REF:0000052
Biological Process	GO:0061386	closure of optic fissure	afap1l2	IMP	ZFIN:ZDB-MRPHLNO-190422-1	Zfish	PMID:30521666
Biological Process	GO:0061386	closure of optic fissure	afap1l2	IMP	ZFIN:ZDB-MRPHLNO-190422-2	Zfish	PMID:30521666
Biological Process	GO:0006954	inflammatory response	AFAP1L2	IDA		Human	PMID:17412687
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	AFAP1L2	IDA		Human	PMID:17412687
Biological Process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	AFAP1L2	IDA		Human	PMID:17412687
Biological Process	GO:0032757	positive regulation of interleukin-8 production	AFAP1L2	IDA		Human	PMID:17412687
Biological Process	GO:0032675	regulation of interleukin-6 production	AFAP1L2	IDA		Human	PMID:17412687
Biological Process	GO:0007346	regulation of mitotic cell cycle	AFAP1L2	IDA		Human	PMID:17412687

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern