Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AFG3L2
  • Mouse genes Afg3l2
  • Rat genes Afg3l2
  • Zfish genes afg3l2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Afg3l2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004222	metalloendopeptidase activity	AFG3L2	IDA		Human	PMID:22354088
Molecular Function	GO:0008237	metallopeptidase activity	AFG3L2	IMP		Human	PMID:27642048
Molecular Function	GO:0005515	protein binding	AFG3L2	IPI	UniProtKB:Q9UQ90	Human	PMID:14623864
Molecular Function	GO:0005515	protein binding	AFG3L2	IPI	UniProtKB:Q9UQ90	Human	PMID:26387735
Molecular Function	GO:0005515	protein binding	AFG3L2	IPI	UniProtKB:Q8WWC4	Human	PMID:27642048
Molecular Function	GO:0005515	protein binding	AFG3L2	IPI	UniProtKB:Q9H4I9	Human	PMID:27642048
Molecular Function	GO:0005515	protein binding	AFG3L2	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	AFG3L2	IPI	UniProtKB:Q9H3K2	Human	PMID:35912435
Molecular Function	GO:0005515	protein binding	Afg3l2	IPI	UniProtKB:O35129,UniProtKB:P67778,UniProtKB:Q9CQV7	Mouse	MGI:MGI:5604945|PMID:24856930
Molecular Function	GO:0005515	protein binding	Afg3l2	IPI	UniProtKB:Q3ULF4	Mouse	MGI:MGI:4833943|PMID:19656850
Cellular Component	GO:0005745	m-AAA complex	Afg3l2	IDA		Mouse	PMID:19656850
Cellular Component	GO:0005743	mitochondrial inner membrane	Afg3l2	IDA		Mouse	MGI:MGI:4833943|PMID:19656850
Cellular Component	GO:0005743	mitochondrial inner membrane	Afg3l2	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005739	mitochondrion	AFG3L2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	AFG3L2	IDA		Human	PMID:22354088
Cellular Component	GO:0005739	mitochondrion	Afg3l2	IGI	MGI:MGI:1914263	Mouse	MGI:MGI:4421613|PMID:20038678
Cellular Component	GO:0005739	mitochondrion	Afg3l2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Afg3l2	IDA		Rat	PMID:24422629|RGD:11532684
Biological Process	GO:0007409	axonogenesis	AFG3L2	IMP		Human	PMID:27642048
Biological Process	GO:0007409	axonogenesis	Afg3l2	IMP	MGI:MGI:1856984	Mouse	PMID:2917690
Biological Process	GO:0036444	calcium import into the mitochondrion	AFG3L2	IMP		Human	PMID:27642048
Biological Process	GO:0042407	cristae formation	Afg3l2	IGI	MGI:MGI:1914263	Mouse	PMID:20038678
Biological Process	GO:0042407	cristae formation	Afg3l2	IGI	MGI:MGI:1928277	Mouse	PMID:20038678
Biological Process	GO:0033619	membrane protein proteolysis	AFG3L2	IDA		Human	PMID:22354088
Biological Process	GO:0051560	mitochondrial calcium ion homeostasis	AFG3L2	IMP		Human	PMID:27642048
Biological Process	GO:0008053	mitochondrial fusion	Afg3l2	IGI	MGI:MGI:1928277	Mouse	PMID:20038678
Biological Process	GO:0034982	mitochondrial protein processing	Afg3l2	IGI	MGI:MGI:1928277	Mouse	PMID:20038678
Biological Process	GO:0034982	mitochondrial protein processing	Afg3l2	IDA		Mouse	PMID:19656850
Biological Process	GO:0007005	mitochondrion organization	Afg3l2	IGI	MGI:MGI:1914263	Mouse	PMID:20038678
Biological Process	GO:0007005	mitochondrion organization	Afg3l2	IGI	MGI:MGI:1928277	Mouse	PMID:20038678
Biological Process	GO:0055001	muscle cell development	Afg3l2	IMP	MGI:MGI:1856984	Mouse	PMID:2917690
Biological Process	GO:0042552	myelination	Afg3l2	IMP	MGI:MGI:1856984	Mouse	PMID:2917690
Biological Process	GO:0021675	nerve development	Afg3l2	IMP	MGI:MGI:1856984	Mouse	PMID:2917690
Biological Process	GO:0007528	neuromuscular junction development	Afg3l2	IMP	MGI:MGI:1856984	Mouse	PMID:2917690
Biological Process	GO:0016540	protein autoprocessing	Afg3l2	IMP		Mouse	MGI:MGI:4833943|PMID:19656850
Biological Process	GO:0016485	protein processing	Afg3l2	IDA		Mouse	MGI:MGI:4833943|PMID:19656850
Biological Process	GO:0006508	proteolysis	AFG3L2	IMP		Human	PMID:27642048
Biological Process	GO:0006508	proteolysis	AFG3L2	IDA		Human	PMID:35912435
Biological Process	GO:0040014	regulation of multicellular organism growth	Afg3l2	IMP	MGI:MGI:1856984	Mouse	PMID:2917690
Biological Process	GO:0060013	righting reflex	Afg3l2	IMP	MGI:MGI:1856984	Mouse	PMID:2917690

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern